PT632039E - Derivados de 2-¬1-(1,2-tiazolina-2-il)-azetidina-3-il|-tio-carbapenem - Google Patents

Derivados de 2-¬1-(1,2-tiazolina-2-il)-azetidina-3-il|-tio-carbapenem

Info

Publication number
PT632039E
PT632039E PT94110186T PT94110186T PT632039E PT 632039 E PT632039 E PT 632039E PT 94110186 T PT94110186 T PT 94110186T PT 94110186 T PT94110186 T PT 94110186T PT 632039 E PT632039 E PT 632039E
Authority
PT
Portugal
Prior art keywords
group
azethydin
carbapenem
thiazoline
tio
Prior art date
Application number
PT94110186T
Other languages
English (en)
Inventor
Takao Abe
Chisato Sato
Satoshi Tamai
Takeshi Isoda
Ado Mihira
Toshio Humagai
Original Assignee
Wyeth Lederle Japan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Lederle Japan Ltd filed Critical Wyeth Lederle Japan Ltd
Publication of PT632039E publication Critical patent/PT632039E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
PT94110186T 1993-07-01 1994-06-30 Derivados de 2-¬1-(1,2-tiazolina-2-il)-azetidina-3-il|-tio-carbapenem PT632039E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP21330693 1993-07-01
JP7932094 1994-03-28
JP12204694 1994-05-12

Publications (1)

Publication Number Publication Date
PT632039E true PT632039E (pt) 2002-06-28

Family

ID=27302982

Family Applications (2)

Application Number Title Priority Date Filing Date
PT99104079T PT924210E (pt) 1993-07-01 1994-06-30 Derivados 2-(1-(1,3-tiazolin-2-il) azetidin-3-il) tiocarbapenem
PT94110186T PT632039E (pt) 1993-07-01 1994-06-30 Derivados de 2-¬1-(1,2-tiazolina-2-il)-azetidina-3-il|-tio-carbapenem

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT99104079T PT924210E (pt) 1993-07-01 1994-06-30 Derivados 2-(1-(1,3-tiazolin-2-il) azetidin-3-il) tiocarbapenem

Country Status (16)

Country Link
US (2) US5534510A (pt)
EP (2) EP0924210B1 (pt)
JP (1) JP2666118B2 (pt)
KR (1) KR100331293B1 (pt)
AT (2) ATE212636T1 (pt)
AU (1) AU682510B2 (pt)
CA (1) CA2127193C (pt)
DE (2) DE69433955T2 (pt)
DK (2) DK0924210T3 (pt)
ES (2) ES2170080T3 (pt)
FI (1) FI106962B (pt)
HU (1) HU220609B1 (pt)
IL (1) IL110161A (pt)
NO (2) NO306780B1 (pt)
PT (2) PT924210E (pt)
TW (1) TW254943B (pt)

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TW432061B (en) * 1994-08-09 2001-05-01 Pfizer Res & Dev Lactams
ATE201410T1 (de) * 1994-12-12 2001-06-15 Wyeth Lederle Japan Ltd Verfahren zur herstellung von 1-(4,5-dihydro)2- thiazolyl-3-azetidinthiolderivaten
TW420681B (en) * 1995-12-08 2001-02-01 Lederle Japan Ltd Carbapenem-3-carboxylic acid ester derivatives
ATE223216T1 (de) 1996-05-09 2002-09-15 Sankyo Co Anti-helicobacter pylori zusammensetzungen die 1- methylcarbapenem-derivate als wirkstoffe enthalten
KR20010079713A (ko) * 1998-09-10 2001-08-22 마쓰자와 도로, 하야시 지로 카르바페넴 화합물
KR100325375B1 (ko) * 2000-01-31 2002-03-06 박호군 이미다졸린 고리가 치환된 카바페넴 유도체
BR0115454A (pt) * 2000-11-16 2003-09-23 Sankyo Co Composto de 1-metilcarbapenem ou um sal ou derivado de éster deste farmaceuticamente aceitável, composição farmacêutica, e, uso de um composto ou de um sal ou derivado de éster deste farmaceuticamente aceitável
KR100441406B1 (ko) * 2001-09-05 2004-07-23 한국과학기술연구원 티아졸리딘 고리 치환체를 갖는 1-β-메틸 카바페넴유도체 및 그 제조 방법
KR100451670B1 (ko) * 2001-09-14 2004-10-08 한국화학연구원 내성균에 대해 항생작용을 갖는 카바페넴 유도체 및 이의제조방법
JP4377231B2 (ja) 2001-11-05 2009-12-02 大日本住友製薬株式会社 新規なカルバペネム化合物
TW200403244A (en) * 2002-05-14 2004-03-01 Sankyo Co 1β-Methylcarbapenem derivatives for oral use
JP4694370B2 (ja) 2002-10-18 2011-06-08 明治製菓株式会社 マロン酸モノエステルおよびその製造方法
JPWO2004035539A1 (ja) * 2002-10-18 2006-02-16 明治製菓株式会社 カルバペネム類の製造方法およびその製造に用いられる中間体
EP1580191A4 (en) * 2002-11-13 2011-03-02 Kaneka Corp PROCESS FOR PRODUCING CARBAPENEM COMPOUND FOR ORAL ADMINISTRATION
EP1612211A4 (en) * 2003-04-08 2008-07-02 Dainippon Sumitomo Pharma Co NEW CARBAPENEM COMPOUNDS
CN1897907B (zh) * 2003-12-30 2012-06-20 麦迪斯技术公司 带有移动控制的超声治疗头
EP1627891A1 (en) * 2004-08-11 2006-02-22 Covion Organic Semiconductors GmbH Polymers for use in organic electroluminescent devices
KR100599876B1 (ko) * 2004-08-31 2006-07-13 한국화학연구원 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법
EP1785426A4 (en) * 2004-09-03 2008-02-20 Dainippon Sumitomo Pharma Co NEW CARBAPENEM DERIVATIVE
JP2006176418A (ja) * 2004-12-21 2006-07-06 Kaneka Corp 経口投与用カルバペネム化合物の製造方法と新規β−ラクタム化合物
EP1864985A4 (en) * 2005-03-25 2010-01-06 Dainippon Sumitomo Pharma Co NEW CARBAPENEM COMPOUND
KR100723889B1 (ko) 2006-06-30 2007-05-31 주식회사 하이닉스반도체 직렬 입/출력 인터페이스를 가진 멀티 포트 메모리 소자
JP5013795B2 (ja) * 2006-09-25 2012-08-29 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 経口投与用カルバペネム
JP2010540433A (ja) * 2007-09-20 2010-12-24 クジェ ファーマシューティカル インダストリアル カンパニー リミテッド カルバペネム系抗生物質の合成中間体の酸付加塩及びその製造方法
JP2011504495A (ja) * 2007-11-23 2011-02-10 クジェ ファーマシューティカル インダストリアル カンパニー リミテッド ２−アリールメチルアゼチジン−カルバペネム−３−カルボン酸エステル誘導体またはその塩、その製造方法及びそれを含む医薬組成物
CN102558181B (zh) * 2010-12-15 2015-04-22 石药集团中奇制药技术（石家庄）有限公司 一种碳青霉烯抗生素的制备方法
CN102731507B (zh) * 2011-04-13 2015-04-01 石药集团中奇制药技术（石家庄）有限公司 泰比培南晶型、其制备方法及其在制备药物中的应用
CN103059026A (zh) * 2011-10-20 2013-04-24 北京康健源科技有限公司 一种替比培南匹夫酯的制备方法
CN102584812B (zh) * 2011-11-18 2014-03-12 深圳万乐药业有限公司 一种泰比培南酯杂质的制备方法
CN102503940B (zh) * 2011-11-22 2013-12-25 深圳万乐药业有限公司 制备泰比培南酯开环杂质的方法
CN103059027A (zh) * 2012-12-20 2013-04-24 安徽悦康凯悦制药有限公司 替比培南匹伏酯的制备方法
KR102640532B1 (ko) * 2016-12-15 2024-02-26 스페로 테라퓨틱스, 인코퍼레이티드 신규한 테비페넴 피복실 속방형 및 변형 방출형 경구 투여형
EA201991618A1 (ru) 2017-02-06 2020-01-30 Сперо Терапьютикс, Инк. Кристаллические формы тебипенема пивоксила, композиции, содержащие их, способы изготовления и способы применения
CN110698469A (zh) * 2019-10-28 2020-01-17 南京红杉生物科技有限公司 泰比培南酯中间体及其合成方法、应用
AU2021378320A1 (en) 2020-11-11 2023-06-22 Spero Therapeutics, Inc. High dosage tebipenem pivoxil tablet formulation

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Also Published As

Publication number Publication date
EP0924210A1 (en) 1999-06-23
NO991019L (no) 1995-01-02
ATE273975T1 (de) 2004-09-15
IL110161A (en) 1998-09-24
FI943164A0 (fi) 1994-07-01
IL110161A0 (en) 1994-10-07
CA2127193C (en) 2005-04-12
EP0632039B1 (en) 2002-01-30
EP0924210B1 (en) 2004-08-18
DK0632039T3 (da) 2002-05-13
NO991019D0 (no) 1999-03-02
ES2170080T3 (es) 2002-08-01
AU6598794A (en) 1995-01-12
ATE212636T1 (de) 2002-02-15
DE69433955T2 (de) 2005-09-08
EP0632039A1 (en) 1995-01-04
CA2127193A1 (en) 1995-01-02
US5679790A (en) 1997-10-21
NO306780B1 (no) 1999-12-20
HU220609B1 (hu) 2002-03-28
JPH0853453A (ja) 1996-02-27
JP2666118B2 (ja) 1997-10-22
DE69429742D1 (de) 2002-03-14
PT924210E (pt) 2004-12-31
NO942483D0 (no) 1994-06-30
NO942483L (no) 1995-01-02
KR100331293B1 (ko) 2002-10-25
FI106962B (fi) 2001-05-15
DK0924210T3 (da) 2004-12-13
FI943164A (fi) 1995-01-02
TW254943B (pt) 1995-08-21
DE69429742T2 (de) 2002-06-06
US5534510A (en) 1996-07-09
KR950003292A (ko) 1995-02-16
AU682510B2 (en) 1997-10-09
HUT68057A (en) 1995-05-29
ES2222630T3 (es) 2005-02-01
HU9401957D0 (en) 1994-09-28
NO307379B1 (no) 2000-03-27
DE69433955D1 (de) 2004-09-23

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