NO942483L - Carbapenem-antibiotika - Google Patents

Carbapenem-antibiotika

Info

Publication number
NO942483L
NO942483L NO942483A NO942483A NO942483L NO 942483 L NO942483 L NO 942483L NO 942483 A NO942483 A NO 942483A NO 942483 A NO942483 A NO 942483A NO 942483 L NO942483 L NO 942483L
Authority
NO
Norway
Prior art keywords
group
hydrogen
alkoxy
carbapenem antibiotics
alkyl
Prior art date
Application number
NO942483A
Other languages
English (en)
Other versions
NO306780B1 (no
NO942483D0 (no
Inventor
Takao Abe
Takeshi Isoda
Chisato Sato
Ado Mihira
Satoshi Tamai
Toshio Kumagai
Original Assignee
Lederle Japan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lederle Japan Ltd filed Critical Lederle Japan Ltd
Publication of NO942483D0 publication Critical patent/NO942483D0/no
Publication of NO942483L publication Critical patent/NO942483L/no
Publication of NO306780B1 publication Critical patent/NO306780B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
NO942483A 1993-07-01 1994-06-30 Carbapenem-antibiotika NO306780B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP21330693 1993-07-01
JP7932094 1994-03-28
JP12204694 1994-05-12

Publications (3)

Publication Number Publication Date
NO942483D0 NO942483D0 (no) 1994-06-30
NO942483L true NO942483L (no) 1995-01-02
NO306780B1 NO306780B1 (no) 1999-12-20

Family

ID=27302982

Family Applications (2)

Application Number Title Priority Date Filing Date
NO942483A NO306780B1 (no) 1993-07-01 1994-06-30 Carbapenem-antibiotika
NO991019A NO307379B1 (no) 1993-07-01 1999-03-02 3-merkapto-1-(1,3-tiazolin-2-yl)azetidin-derivater

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO991019A NO307379B1 (no) 1993-07-01 1999-03-02 3-merkapto-1-(1,3-tiazolin-2-yl)azetidin-derivater

Country Status (16)

Country Link
US (2) US5534510A (no)
EP (2) EP0924210B1 (no)
JP (1) JP2666118B2 (no)
KR (1) KR100331293B1 (no)
AT (2) ATE273975T1 (no)
AU (1) AU682510B2 (no)
CA (1) CA2127193C (no)
DE (2) DE69433955T2 (no)
DK (2) DK0924210T3 (no)
ES (2) ES2222630T3 (no)
FI (1) FI106962B (no)
HU (1) HU220609B1 (no)
IL (1) IL110161A (no)
NO (2) NO306780B1 (no)
PT (2) PT632039E (no)
TW (1) TW254943B (no)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5783703A (en) * 1993-07-01 1998-07-21 Lederle (Japan), Ltd. Sulfur-containing compounds method for their use and prodction
TW432061B (en) * 1994-08-09 2001-05-01 Pfizer Res & Dev Lactams
ATE201410T1 (de) * 1994-12-12 2001-06-15 Wyeth Lederle Japan Ltd Verfahren zur herstellung von 1-(4,5-dihydro)2- thiazolyl-3-azetidinthiolderivaten
TW420681B (en) * 1995-12-08 2001-02-01 Lederle Japan Ltd Carbapenem-3-carboxylic acid ester derivatives
EP0913151B1 (en) 1996-05-09 2002-09-04 Sankyo Company, Limited Anti-helicobacter pylori compositions containing 1-methylcarbapenem derivatives as the active ingredient
AU5450199A (en) * 1998-09-10 2000-04-03 Wyeth Lederle Japan, Ltd. Carbapenem compounds
KR100325375B1 (ko) * 2000-01-31 2002-03-06 박호군 이미다졸린 고리가 치환된 카바페넴 유도체
DE60123827T2 (de) * 2000-11-16 2007-05-31 Sankyo Co., Ltd. 1-methylcarbapenemderivate
KR100441406B1 (ko) * 2001-09-05 2004-07-23 한국과학기술연구원 티아졸리딘 고리 치환체를 갖는 1-β-메틸 카바페넴유도체 및 그 제조 방법
KR100451670B1 (ko) * 2001-09-14 2004-10-08 한국화학연구원 내성균에 대해 항생작용을 갖는 카바페넴 유도체 및 이의제조방법
KR100945706B1 (ko) * 2001-11-05 2010-03-05 다이닛본 스미토모 세이야꾸 가부시끼가이샤 신규 카르바페넴 화합물
TW200403244A (en) * 2002-05-14 2004-03-01 Sankyo Co 1β-Methylcarbapenem derivatives for oral use
JPWO2004035539A1 (ja) * 2002-10-18 2006-02-16 明治製菓株式会社 カルバペネム類の製造方法およびその製造に用いられる中間体
JP4694370B2 (ja) 2002-10-18 2011-06-08 明治製菓株式会社 マロン酸モノエステルおよびその製造方法
KR101059339B1 (ko) 2002-11-13 2011-08-24 가부시키가이샤 가네카 경구 투여용 카르바페넴 화합물의 제조 방법
CA2519794A1 (en) * 2003-04-08 2004-10-21 Sumitomo Pharmaceuticals Co., Ltd. Novel carbapenem compounds
EP1699407A4 (en) * 2003-12-30 2010-12-01 Medicis Technologies Corp ULTRASOUND THERAPY HEAD WITH MOTION CONTROL
EP1627891A1 (en) * 2004-08-11 2006-02-22 Covion Organic Semiconductors GmbH Polymers for use in organic electroluminescent devices
KR100599876B1 (ko) 2004-08-31 2006-07-13 한국화학연구원 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법
CA2577924A1 (en) * 2004-09-03 2006-03-09 Dainippon Sumitomo Pharma Co., Ltd. Novel carbapenem compound
JP2006176418A (ja) * 2004-12-21 2006-07-06 Kaneka Corp 経口投与用カルバペネム化合物の製造方法と新規β−ラクタム化合物
JPWO2006103999A1 (ja) * 2005-03-25 2008-09-04 大日本住友製薬株式会社 新規なカルバペネム化合物
KR100723889B1 (ko) 2006-06-30 2007-05-31 주식회사 하이닉스반도체 직렬 입/출력 인터페이스를 가진 멀티 포트 메모리 소자
JP5013795B2 (ja) * 2006-09-25 2012-08-29 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 経口投与用カルバペネム
CN101848911A (zh) * 2007-09-20 2010-09-29 国际药品工业株式会社 碳青霉烯类抗生素的合成中间体的酸加成盐及其制备方法
CN101868460A (zh) * 2007-11-23 2010-10-20 国际药品工业株式会社 2-芳基甲基吖丁啶-碳青霉烯-3-羧酸酯衍生物或其盐、其制备方法以及包含上述的药物组合物
CN102558181B (zh) * 2010-12-15 2015-04-22 石药集团中奇制药技术（石家庄）有限公司 一种碳青霉烯抗生素的制备方法
CN102731507B (zh) * 2011-04-13 2015-04-01 石药集团中奇制药技术（石家庄）有限公司 泰比培南晶型、其制备方法及其在制备药物中的应用
CN103059026A (zh) * 2011-10-20 2013-04-24 北京康健源科技有限公司 一种替比培南匹夫酯的制备方法
CN102584812B (zh) * 2011-11-18 2014-03-12 深圳万乐药业有限公司 一种泰比培南酯杂质的制备方法
CN102503940B (zh) * 2011-11-22 2013-12-25 深圳万乐药业有限公司 制备泰比培南酯开环杂质的方法
CN103059027A (zh) * 2012-12-20 2013-04-24 安徽悦康凯悦制药有限公司 替比培南匹伏酯的制备方法
KR102640532B1 (ko) * 2016-12-15 2024-02-26 스페로 테라퓨틱스, 인코퍼레이티드 신규한 테비페넴 피복실 속방형 및 변형 방출형 경구 투여형
EA201991618A1 (ru) 2017-02-06 2020-01-30 Сперо Терапьютикс, Инк. Кристаллические формы тебипенема пивоксила, композиции, содержащие их, способы изготовления и способы применения
CN110698469A (zh) * 2019-10-28 2020-01-17 南京红杉生物科技有限公司 泰比培南酯中间体及其合成方法、应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3665001A (en) * 1970-06-11 1972-05-23 Exxon Research Engineering Co Azinyl organophosphorus compounds
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
US4696923A (en) * 1984-04-23 1987-09-29 Merck & Co., Inc. 6-[1-hydroxyethyl]-2-SR8 -1-methyl-1-carbadethiapen-2-em-3-carboxylic acids
JPS63255280A (ja) * 1987-04-11 1988-10-21 Nippon Redarii Kk （１ｒ，５ｓ，６ｓ）−２−置換−６−〔（ｒ）−１−ヒドロキシエチル〕−１−メチル−カルバペネム−３−カルボン酸誘導体
GB9210096D0 (en) * 1992-05-11 1992-06-24 Fujisawa Pharmaceutical Co 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives and their preparation

Also Published As

Publication number Publication date
NO306780B1 (no) 1999-12-20
FI943164A (fi) 1995-01-02
ES2222630T3 (es) 2005-02-01
KR950003292A (ko) 1995-02-16
US5534510A (en) 1996-07-09
AU682510B2 (en) 1997-10-09
DE69429742T2 (de) 2002-06-06
US5679790A (en) 1997-10-21
EP0924210B1 (en) 2004-08-18
CA2127193C (en) 2005-04-12
FI106962B (fi) 2001-05-15
ATE212636T1 (de) 2002-02-15
DE69429742D1 (de) 2002-03-14
KR100331293B1 (ko) 2002-10-25
TW254943B (no) 1995-08-21
FI943164A0 (fi) 1994-07-01
NO942483D0 (no) 1994-06-30
EP0632039A1 (en) 1995-01-04
IL110161A (en) 1998-09-24
PT924210E (pt) 2004-12-31
NO307379B1 (no) 2000-03-27
JPH0853453A (ja) 1996-02-27
DK0632039T3 (da) 2002-05-13
DE69433955T2 (de) 2005-09-08
HUT68057A (en) 1995-05-29
ATE273975T1 (de) 2004-09-15
JP2666118B2 (ja) 1997-10-22
HU220609B1 (hu) 2002-03-28
EP0924210A1 (en) 1999-06-23
DK0924210T3 (da) 2004-12-13
HU9401957D0 (en) 1994-09-28
ES2170080T3 (es) 2002-08-01
PT632039E (pt) 2002-06-28
EP0632039B1 (en) 2002-01-30
IL110161A0 (en) 1994-10-07
CA2127193A1 (en) 1995-01-02
NO991019L (no) 1995-01-02
AU6598794A (en) 1995-01-12
NO991019D0 (no) 1999-03-02
DE69433955D1 (de) 2004-09-23

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Legal Events

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