FI885332A - 3-/4-(-1-substituerad-4-piperazinyl) butyl/-4-tiazolidinoner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel. - Google Patents

3-/4-(-1-substituerad-4-piperazinyl) butyl/-4-tiazolidinoner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel. Download PDF

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Publication number
FI885332A
FI885332A FI885332A FI885332A FI885332A FI 885332 A FI885332 A FI 885332A FI 885332 A FI885332 A FI 885332A FI 885332 A FI885332 A FI 885332A FI 885332 A FI885332 A FI 885332A
Authority
FI
Finland
Prior art keywords
loweralkyl
deras
thiazolidinoner
substituerad
piperazinyl
Prior art date
Application number
FI885332A
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English (en)
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FI89916C (fi
FI89916B (fi
FI885332A0 (fi
Inventor
Nicholas J Hrib
John Gerard Jurcak
Original Assignee
Hoechst Roussel Pharma
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Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of FI885332A0 publication Critical patent/FI885332A0/fi
Publication of FI885332A publication Critical patent/FI885332A/fi
Application granted granted Critical
Publication of FI89916B publication Critical patent/FI89916B/fi
Publication of FI89916C publication Critical patent/FI89916C/fi

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI885332A 1987-11-20 1988-11-17 Foerfarande foer framstaellning av terapeutiskt anvaendbara 3-/4-(1-substituerade-4-piperazinyl)butyl/-4-tiazolidinoner FI89916C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12362287A 1987-11-20 1987-11-20
US12362287 1987-11-20

Publications (4)

Publication Number Publication Date
FI885332A0 FI885332A0 (fi) 1988-11-17
FI885332A true FI885332A (fi) 1989-05-21
FI89916B FI89916B (fi) 1993-08-31
FI89916C FI89916C (fi) 1993-12-10

Family

ID=22409774

Family Applications (1)

Application Number Title Priority Date Filing Date
FI885332A FI89916C (fi) 1987-11-20 1988-11-17 Foerfarande foer framstaellning av terapeutiskt anvaendbara 3-/4-(1-substituerade-4-piperazinyl)butyl/-4-tiazolidinoner

Country Status (20)

Country Link
US (5) US4933453A (fi)
EP (1) EP0316723B1 (fi)
JP (1) JP2617546B2 (fi)
KR (1) KR0130976B1 (fi)
AT (1) ATE81123T1 (fi)
AU (1) AU624092B2 (fi)
CA (1) CA1317955C (fi)
DE (1) DE3875073T2 (fi)
DK (1) DK645688A (fi)
ES (1) ES2052675T3 (fi)
FI (1) FI89916C (fi)
GR (1) GR3006698T3 (fi)
HU (1) HU206709B (fi)
IE (1) IE62229B1 (fi)
IL (1) IL88414A (fi)
NO (1) NO176143C (fi)
NZ (1) NZ226999A (fi)
PH (1) PH27330A (fi)
PT (1) PT89020B (fi)
ZA (1) ZA888651B (fi)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801186A (en) * 1987-11-20 1998-09-01 Hoechst Marion Roussel, Inc. 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
ATE81123T1 (de) * 1987-11-20 1992-10-15 Hoechst Roussel Pharma 3-(4(1-substituierte-4-piperazinyl)butyl>-4thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel.
WO1991000863A1 (en) * 1989-07-07 1991-01-24 Pfizer Inc. Heteroaryl piperazine antipsychotic agents
HU205092B (en) * 1989-11-24 1992-03-30 Richter Gedeon Vegyeszet Process for producing new thiazolidinone derivatives and pharmaceutical compositions comprising same
US5216002A (en) * 1989-12-21 1993-06-01 Eli Lilly And Company Method of treating inflammatory bowel disease
US5034392A (en) * 1990-04-16 1991-07-23 Hoechst-Roussel Pharmaceuticals Incorporated 4-(3-(4-oxothiazolidinyl)butynylamines
US5041445A (en) * 1990-05-21 1991-08-20 Hoechst-Roussel Pharmaceuticals Incorporated 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles
US5045546A (en) * 1990-10-26 1991-09-03 Hoechst-Roussel Pharmaceuticals Inc. 8-azabicyclo[3.2.1]octylalkylthiazolidines
US5194436A (en) * 1991-01-10 1993-03-16 Hoechst-Roussel Pharmaceuticals Inc. 1-piperazinyl-2-butenes and -2-butynes
US5130315A (en) * 1991-01-10 1992-07-14 Raymond R. Wittekind 1-piperazinyl-2-butenes and -2-butynes
US5240927A (en) * 1992-05-19 1993-08-31 Hoechst-Roussel Pharmaceuticals Incorporated Benzo[β]thiophen-3-yl piperazines as antipsychotic agents
AU664084B2 (en) * 1992-06-03 1995-11-02 Ciba-Geigy Ag Novel thiosemicarbazonic acid esters
US5272148A (en) * 1992-09-09 1993-12-21 Hoechst-Roussel Pharmaceuticals Incorporated Heteroarenylpiperazines
US5599815A (en) * 1993-02-04 1997-02-04 Meiji Seika Kabushiki Kaisha Antipsychotic benzoisothiazolyl piperazine derivatives
US5391570A (en) * 1993-10-14 1995-02-21 Bristol-Myers Squibb Aminomethyl-benzodioxane and benzopyran serotonergic agents
CA2157348A1 (en) * 1994-09-01 1996-03-02 Aventis Pharmaceuticals Inc. 3-¬4-(1-substituted-4-piperazinyl)butyl|-4-thiazolidinone and related compounds
KR960022486A (ko) * 1994-12-29 1996-07-18 김준웅 신규 티아졸리딘-4-온 유도체
EP0732332B1 (en) * 1995-03-17 2001-12-19 Aventis Pharmaceuticals Inc. Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation
KR970032857A (ko) * 1995-12-29 1997-07-22 김준웅 약제 조성물
US5880121A (en) * 1996-01-05 1999-03-09 Hoechst Marion Roussel Inc. 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
US6506751B1 (en) 1999-11-12 2003-01-14 Millennium Pharmaceuticals, Inc. Thiazolidinone compounds useful as chemokine inhibitors
US7122376B2 (en) * 2001-11-01 2006-10-17 Facet Analytical Services And Technology, Llc Calibration standards, methods, and kits for water determination
US7049146B2 (en) * 2000-11-14 2006-05-23 Facet Analytical Services And Technology, Llc Calibration standards, methods, and kits for water determination
WO2003008398A1 (en) * 2001-07-16 2003-01-30 Euro-Celtique S.A. Aryl substituted thiazolidinones and the use thereof
US20040131504A1 (en) * 2002-09-17 2004-07-08 Landers James P. Remote temperature sensing of small volume and related apparatus thereof
PL2159226T3 (pl) * 2007-03-29 2017-02-28 Joint-Stock Company "Obninsk Chemical Pharmaceutical Company" Środek antyhistaminowy i antyalergiczny oraz sposób jego wytwarzania
JP2012504640A (ja) * 2008-10-02 2012-02-23 アボット・ラボラトリーズ カルシウムチャネル遮断薬としての新規な化合物
US8815869B2 (en) * 2010-03-18 2014-08-26 Abbvie Inc. Lactam acetamides as calcium channel blockers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2520179A (en) * 1949-02-02 1950-08-29 Sterling Drug Inc 4-thiazolidones and a method for preparation thereof
JPS51125389A (en) * 1975-04-09 1976-11-01 Yoshitomi Pharmaceut Ind Ltd A process for preparing heterocyclic compovnds
US4456756A (en) * 1981-08-03 1984-06-26 Mead Johnson & Company Spirothiazolidinyl piperazine derivatives
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4619930A (en) * 1985-01-16 1986-10-28 Bristol-Myers Company Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use
GB8512163D0 (en) * 1985-05-14 1985-06-19 Fujisawa Pharmaceutical Co Oxothiazolidine compound
ATE81123T1 (de) * 1987-11-20 1992-10-15 Hoechst Roussel Pharma 3-(4(1-substituierte-4-piperazinyl)butyl>-4thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel.
US5041445A (en) * 1990-05-21 1991-08-20 Hoechst-Roussel Pharmaceuticals Incorporated 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles

Also Published As

Publication number Publication date
NO176143B (no) 1994-10-31
ES2052675T3 (es) 1994-07-16
FI89916C (fi) 1993-12-10
ATE81123T1 (de) 1992-10-15
NO885152L (no) 1989-05-22
DK645688A (da) 1989-05-21
NO885152D0 (no) 1988-11-18
KR0130976B1 (ko) 1998-04-16
CA1317955C (en) 1993-05-18
DK645688D0 (da) 1988-11-18
DE3875073T2 (de) 1993-03-11
AU2569488A (en) 1989-05-25
US5229388A (en) 1993-07-20
AU624092B2 (en) 1992-06-04
PH27330A (en) 1993-06-08
GR3006698T3 (fi) 1993-06-30
HU206709B (en) 1992-12-28
IL88414A (en) 1993-07-08
PT89020B (pt) 1993-02-26
US5136037A (en) 1992-08-04
FI89916B (fi) 1993-08-31
DE3875073D1 (fi) 1992-11-05
JPH01160975A (ja) 1989-06-23
IE883463L (en) 1989-05-20
US5371087A (en) 1994-12-06
US4933453A (en) 1990-06-12
KR890008137A (ko) 1989-07-10
NZ226999A (en) 1991-05-28
NO176143C (no) 1995-02-08
ZA888651B (en) 1989-09-27
IL88414A0 (en) 1989-06-30
EP0316723A1 (en) 1989-05-24
EP0316723B1 (en) 1992-09-30
FI885332A0 (fi) 1988-11-17
US5037984A (en) 1991-08-06
JP2617546B2 (ja) 1997-06-04
HUT54149A (en) 1991-01-28
IE62229B1 (en) 1995-01-11
PT89020A (pt) 1988-12-01

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BB Publication of examined application
PC Transfer of assignment of patent

Owner name: HOECHST MARION ROUSSEL, INC.

MM Patent lapsed

Owner name: HOECHST MARION ROUSSEL INC., INC.