ES8304120A1 - Un procedimiento para la preparacion de nuevos derivados de acilaminoquimazolina. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de acilaminoquimazolina.Info
- Publication number
- ES8304120A1 ES8304120A1 ES507482A ES507482A ES8304120A1 ES 8304120 A1 ES8304120 A1 ES 8304120A1 ES 507482 A ES507482 A ES 507482A ES 507482 A ES507482 A ES 507482A ES 8304120 A1 ES8304120 A1 ES 8304120A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- substituted phenyl
- optionally substituted
- lower alkyl
- acylaminoquinazoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACILAMINOQUINAZOLINA Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES HIDROGENO O ALQUILO INFERIOR; R ES HIDROGENO O FENILO SUSTITUIDO CON ALCOXI; X ES METILENO O AZUFRE; R Y R PUEDEN SER VARIOS TIPOS DE RADICALES; Y N VALE 2 O 3. CONSISTE EN LA REACCION DE UN DERIVADO DE 4-AMINOQUINAZOLINA, DE FORMULA (II), CON UN ACIDO CARBOXILICO O UN DERIVADO REACTIVO DEL MISMO, DE FORMULA (III), EN LAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN ACEPTOR DE ACIDO, A UNA TEMPERATURA ENTRE -10 C Y 60 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIHIPERTENSIVOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55166327A JPS5793977A (en) | 1980-11-26 | 1980-11-26 | Acylaminoquinazoline derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8304120A1 true ES8304120A1 (es) | 1983-02-16 |
ES507482A0 ES507482A0 (es) | 1983-02-16 |
Family
ID=15829296
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES507482A Granted ES507482A0 (es) | 1980-11-26 | 1981-11-26 | Un procedimiento para la preparacion de nuevos derivados de acilaminoquimazolina. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4495188A (es) |
EP (1) | EP0053047B1 (es) |
JP (1) | JPS5793977A (es) |
CA (1) | CA1161434A (es) |
DE (1) | DE3164469D1 (es) |
ES (1) | ES507482A0 (es) |
FI (1) | FI813801L (es) |
PH (1) | PH18595A (es) |
ZA (1) | ZA818176B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS236097B1 (en) * | 1983-06-01 | 1985-05-15 | Jan Koenig | Acylderivatives of 2-piperazinochinazoline and method of their preparation |
US5565567A (en) * | 1993-06-04 | 1996-10-15 | Henkel Corporation. | Polymerizable N,N'-substituted piperazine acrylamide compounds |
US5922820A (en) * | 1993-06-04 | 1999-07-13 | Henkel Corporation | Polymerizable compounds |
CA2164330A1 (en) * | 1993-06-04 | 1994-12-22 | Paul E. Share | Polymerizable compounds |
US5563214A (en) * | 1994-08-09 | 1996-10-08 | Henkel Corporation | Aqueous compositions containing polymerizable surfactant compounds |
EP0853479A4 (en) * | 1995-09-29 | 2001-04-11 | Merck & Co Inc | ALPHA 1b ADRENERGIC RECEPTOR ANTAGONISTS |
US5756742A (en) * | 1995-12-22 | 1998-05-26 | Henkel Corporation | Polymerizable compounds |
WO2005121094A1 (en) * | 2004-06-09 | 2005-12-22 | Pfizer Limited | Piperazine and piperidine derivatives as anti-hiv-agents |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3511836A (en) * | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
US3574212A (en) * | 1968-02-02 | 1971-04-06 | Pfizer | Quinazolinylureas |
US3663706A (en) * | 1969-09-29 | 1972-05-16 | Pfizer | Use of 2,4-diaminoquinazolines as hypotensive agents |
US3971783A (en) * | 1973-03-07 | 1976-07-27 | Pfizer Inc. | 4-Aminoquinazoline derivatives as cardiac stimulants |
US4105776A (en) * | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
US4001238A (en) * | 1976-02-18 | 1977-01-04 | Bristol-Myers Company | 1,3,4-oxadiazole amides |
US4001237A (en) * | 1976-02-18 | 1977-01-04 | Bristol-Myers Company | Oxazole, isoxazole, thiazole and isothiazole amides |
DE2623846A1 (de) * | 1976-05-28 | 1977-12-15 | Hoechst Ag | 4-chinazolinyl-guanidine und verfahren zu ihrer herstellung |
GR69201B (es) * | 1976-08-06 | 1982-05-06 | Pfizer | |
US4062844A (en) * | 1976-09-20 | 1977-12-13 | Pfizer Inc. | Process for preparing hypotensive 2-(4-aroylpiperazin-1-yl)-amino-6,7-dimethoxyquinazolines |
US4192945A (en) * | 1978-12-07 | 1980-03-11 | E. R. Squibb & Sons, Inc. | Process for preparing proline and homoproline derivatives |
-
1980
- 1980-11-26 JP JP55166327A patent/JPS5793977A/ja active Granted
-
1981
- 1981-11-24 US US06/324,425 patent/US4495188A/en not_active Expired - Fee Related
- 1981-11-25 ZA ZA818176A patent/ZA818176B/xx unknown
- 1981-11-26 CA CA000390963A patent/CA1161434A/en not_active Expired
- 1981-11-26 DE DE8181305612T patent/DE3164469D1/de not_active Expired
- 1981-11-26 FI FI813801A patent/FI813801L/fi not_active Application Discontinuation
- 1981-11-26 PH PH26539A patent/PH18595A/en unknown
- 1981-11-26 EP EP81305612A patent/EP0053047B1/en not_active Expired
- 1981-11-26 ES ES507482A patent/ES507482A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
EP0053047B1 (en) | 1984-06-27 |
CA1161434A (en) | 1984-01-31 |
US4495188A (en) | 1985-01-22 |
PH18595A (en) | 1985-08-15 |
EP0053047A1 (en) | 1982-06-02 |
DE3164469D1 (en) | 1984-08-02 |
JPS5793977A (en) | 1982-06-11 |
ZA818176B (en) | 1982-11-24 |
FI813801L (fi) | 1982-05-27 |
ES507482A0 (es) | 1983-02-16 |
JPS6330910B2 (es) | 1988-06-21 |
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