PT870765E - Derivados de aminotiazole drogas contendo os mesmos e intermediarios na producao dos compostos - Google Patents
Derivados de aminotiazole drogas contendo os mesmos e intermediarios na producao dos compostosInfo
- Publication number
- PT870765E PT870765E PT96915167T PT96915167T PT870765E PT 870765 E PT870765 E PT 870765E PT 96915167 T PT96915167 T PT 96915167T PT 96915167 T PT96915167 T PT 96915167T PT 870765 E PT870765 E PT 870765E
- Authority
- PT
- Portugal
- Prior art keywords
- group
- lower alkyl
- hydrogen atom
- alkyl group
- aminotiazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14239995 | 1995-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT870765E true PT870765E (pt) | 2004-03-31 |
Family
ID=15314454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96915167T PT870765E (pt) | 1995-05-18 | 1996-05-16 | Derivados de aminotiazole drogas contendo os mesmos e intermediarios na producao dos compostos |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5981557A (pt) |
| EP (1) | EP0870765B1 (pt) |
| JP (1) | JP3181919B2 (pt) |
| KR (1) | KR100424933B1 (pt) |
| CN (1) | CN1063442C (pt) |
| AT (1) | ATE254609T1 (pt) |
| AU (1) | AU699008B2 (pt) |
| CA (1) | CA2219747C (pt) |
| DE (1) | DE69630806T2 (pt) |
| DK (1) | DK0870765T3 (pt) |
| ES (1) | ES2210366T3 (pt) |
| PT (1) | PT870765E (pt) |
| TW (1) | TW445260B (pt) |
| WO (1) | WO1996036619A1 (pt) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2269531C (en) * | 1996-10-24 | 2006-03-14 | Zeria Pharmaceutical Co., Ltd. | Substituted benzoylaminothiazole derivatives and drugs containing the same |
| PT994108E (pt) * | 1997-06-24 | 2003-09-30 | Zeria Pharm Co Ltd | Processo de producao de derivados de 2-hidroxibenzamida |
| WO1999029843A1 (en) | 1997-12-11 | 1999-06-17 | Smithkline Beecham Corporation | Hepatitis c virus ns5b truncated protein and methods thereof to identify antiviral compounds |
| SE9803773D0 (sv) * | 1998-11-05 | 1998-11-05 | Astra Pharma Prod | Compounds |
| DE60124117T8 (de) * | 2000-09-08 | 2007-05-31 | Zeria Pharmaceutical Co., Ltd. | Aminothiazol-derivate enthaltende pharmazeutische zusammensetzungen zur behandlung von motorischen störungen des kolons |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| SI1493441T1 (sl) * | 2002-04-08 | 2011-12-30 | Zeria Pharm Co Ltd | Terapevtsko sredstvo za motnjo prilagoditve Ĺľelodca na zauĹľito prehrano |
| JP2005533101A (ja) * | 2002-07-10 | 2005-11-04 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | アロステリック阻害剤又はマトリックス金属タンパク質分解酵素−１３の、セレコキシブでもバルデコキシブでもないシクロオキシゲナーゼ−２の選択的阻害剤との組合せ物 |
| US20040010035A1 (en) * | 2002-07-15 | 2004-01-15 | Ciociola Arthur A. | Gastrointestinal compositions |
| US6986901B2 (en) * | 2002-07-15 | 2006-01-17 | Warner-Lambert Company Llc | Gastrointestinal compositions |
| GB0412468D0 (en) * | 2004-06-04 | 2004-07-07 | Astrazeneca Ab | Chemical compounds |
| US8586761B2 (en) * | 2004-08-23 | 2013-11-19 | Zeria Pharmaceutical Co., Ltd. | Method for producing aminothiazole derivative and production intermediate |
| AU2011244991B2 (en) * | 2004-08-23 | 2012-08-23 | Zeria Pharmaceutical Co., Ltd. | Method for producing aminothiazole derivative and production intermediate |
| CN101006040B (zh) * | 2004-08-23 | 2011-07-27 | 泽里新药工业株式会社 | 氨基噻唑衍生物的制备方法及制备中间体 |
| JP2008513386A (ja) * | 2004-09-20 | 2008-05-01 | ４エスシー アーゲー | 新規な複素環式ＮＦ−κＢ阻害剤 |
| US7910613B2 (en) | 2004-09-22 | 2011-03-22 | H. Lundbeck A/S | 2-acylaminothiazole derivatives |
| US7552781B2 (en) | 2004-10-20 | 2009-06-30 | Black & Decker Inc. | Power tool anti-kickback system with rotational rate sensor |
| US7674912B2 (en) | 2005-04-25 | 2010-03-09 | H. Lundbeck A/S | Pro-drugs of N-thiazol-2-yl-benzamide derivatives |
| NZ588971A (en) * | 2005-07-29 | 2012-06-29 | 4Sc Discovery Gmbh | Novel heterocyclic NF-kappaB inhibitors |
| JP2007119416A (ja) * | 2005-10-31 | 2007-05-17 | Bayer Cropscience Ag | 殺虫性２−アシルアミノチアゾール−４−カルボキサミド類 |
| WO2007116901A1 (ja) * | 2006-04-05 | 2007-10-18 | Banyu Pharmaceutical Co., Ltd. | 新規アリールアミド誘導体 |
| JP5441052B2 (ja) * | 2009-07-16 | 2014-03-12 | ゼリア新薬工業株式会社 | アルツハイマー病治療薬 |
| EP2521832B1 (en) | 2010-01-07 | 2020-03-25 | Black & Decker, Inc. | Power screwdriver having rotary input control |
| US9475180B2 (en) | 2010-01-07 | 2016-10-25 | Black & Decker Inc. | Power tool having rotary input control |
| US8418778B2 (en) | 2010-01-07 | 2013-04-16 | Black & Decker Inc. | Power screwdriver having rotary input control |
| US9266178B2 (en) | 2010-01-07 | 2016-02-23 | Black & Decker Inc. | Power tool having rotary input control |
| CN103204824B (zh) * | 2012-01-12 | 2015-04-08 | 清华大学深圳研究生院 | 2-氨基噻唑-4-酰胺类衍生物及其制备方法与应用 |
| EP2631035B1 (en) | 2012-02-24 | 2019-10-16 | Black & Decker Inc. | Power tool |
| CN103387552B (zh) * | 2012-05-10 | 2016-06-08 | 常州市第四制药厂有限公司 | 制备盐酸阿考替胺的方法 |
| CN104447612A (zh) * | 2013-09-16 | 2015-03-25 | 天津市汉康医药生物技术有限公司 | 阿考替胺水合物晶型及其制备方法和用途 |
| CN103896873B (zh) * | 2013-10-23 | 2015-11-25 | 山东诚创医药技术开发有限公司 | 一种盐酸阿考替胺的精制方法 |
| CN104592147A (zh) * | 2013-10-30 | 2015-05-06 | 江苏豪森药业股份有限公司 | 盐酸阿考替胺中间体的制备方法 |
| CN103665023B (zh) * | 2013-12-23 | 2017-05-24 | 华润赛科药业有限责任公司 | 一种盐酸阿考替胺的合成方法 |
| CN103980226A (zh) * | 2014-05-10 | 2014-08-13 | 杭州新博思生物医药有限公司 | 盐酸阿考替胺水合物晶型及其制备方法 |
| CN104031001B (zh) * | 2014-06-30 | 2015-09-30 | 山东诚创医药技术开发有限公司 | 一锅烩制备2-[n-(2,4,5-三甲氧基苯甲胺基)氨基]-4-乙氧羰基-1,3-噻唑的方法 |
| CN104130207B (zh) * | 2014-07-07 | 2016-08-24 | 湖北华世通生物医药科技有限公司 | 阿考替胺氢溴酸盐水合物及其晶型的制备方法 |
| CN105439977A (zh) * | 2014-09-26 | 2016-03-30 | 广州朗圣药业有限公司 | 一种阿考替胺及其盐酸盐的制备方法 |
| CN105924406B (zh) * | 2016-05-04 | 2018-04-10 | 河北国龙制药有限公司 | 一种盐酸阿考替胺三水合物的制备方法 |
| US10589413B2 (en) | 2016-06-20 | 2020-03-17 | Black & Decker Inc. | Power tool with anti-kickback control system |
| KR102453655B1 (ko) * | 2017-10-25 | 2022-10-12 | (주)헥사파마텍 | 아코티아미드의 개선된 제조방법 |
| CN108358867A (zh) * | 2018-05-05 | 2018-08-03 | 邳州易萨新型材料有限公司 | 一种盐酸阿考替胺的合成方法 |
| CN109776447B (zh) * | 2019-02-28 | 2021-03-02 | 常州市阳光药业有限公司 | 盐酸阿考替胺工业化生产方法 |
| CN109988121B (zh) * | 2019-04-28 | 2023-01-03 | 梯尔希（南京）药物研发有限公司 | 一种阿考替胺衍生物的制备方法 |
| CN111518052A (zh) * | 2020-05-27 | 2020-08-11 | 廊坊市泽康医药科技有限公司 | 一种阿考替胺盐酸盐杂质的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4829073A (en) * | 1988-05-12 | 1989-05-09 | Bristol-Myers Company | Thiadiazole oxides for treating gastrointestinal motility disorders |
| JPH0730064B2 (ja) * | 1989-08-17 | 1995-04-05 | 協和醗酵工業株式会社 | フラン誘導体 |
| US5424431A (en) * | 1990-10-24 | 1995-06-13 | Yamanouchi Pharmaceutical Co., Ltd. | Thiazole derivatives |
| JP3029876B2 (ja) * | 1991-03-05 | 2000-04-10 | 協和醗酵工業株式会社 | フラン誘導体 |
| JPH1135565A (ja) * | 1993-10-25 | 1999-02-09 | Zeria Pharmaceut Co Ltd | チアゾール誘導体、それを含有する医薬および該化合物の製造中間体 |
| US5510478A (en) * | 1994-11-30 | 1996-04-23 | American Home Products Corporation | 2-arylamidothiazole derivatives with CNS activity |
| US5712270A (en) * | 1995-11-06 | 1998-01-27 | American Home Products Corporation | 2-arylamidothiazole derivatives with CNS activity |
-
1996
- 1996-05-16 CA CA002219747A patent/CA2219747C/en not_active Expired - Lifetime
- 1996-05-16 JP JP53470396A patent/JP3181919B2/ja not_active Expired - Lifetime
- 1996-05-16 DE DE69630806T patent/DE69630806T2/de not_active Expired - Lifetime
- 1996-05-16 KR KR1019970707808A patent/KR100424933B1/ko not_active IP Right Cessation
- 1996-05-16 DK DK96915167T patent/DK0870765T3/da active
- 1996-05-16 CN CN96194002A patent/CN1063442C/zh not_active Expired - Lifetime
- 1996-05-16 AU AU57024/96A patent/AU699008B2/en not_active Expired
- 1996-05-16 PT PT96915167T patent/PT870765E/pt unknown
- 1996-05-16 EP EP96915167A patent/EP0870765B1/en not_active Expired - Lifetime
- 1996-05-16 ES ES96915167T patent/ES2210366T3/es not_active Expired - Lifetime
- 1996-05-16 AT AT96915167T patent/ATE254609T1/de active
- 1996-05-16 WO PCT/JP1996/001297 patent/WO1996036619A1/ja active IP Right Grant
- 1996-05-16 US US08/952,106 patent/US5981557A/en not_active Expired - Lifetime
- 1996-05-17 TW TW085105855A patent/TW445260B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100424933B1 (ko) | 2004-07-27 |
| CA2219747C (en) | 2008-11-25 |
| ATE254609T1 (de) | 2003-12-15 |
| WO1996036619A1 (fr) | 1996-11-21 |
| DE69630806D1 (de) | 2003-12-24 |
| JP3181919B2 (ja) | 2001-07-03 |
| AU5702496A (en) | 1996-11-29 |
| CA2219747A1 (en) | 1996-11-21 |
| EP0870765A4 (pt) | 1998-10-14 |
| US5981557A (en) | 1999-11-09 |
| KR19990008282A (ko) | 1999-01-25 |
| DE69630806T2 (de) | 2004-04-15 |
| AU699008B2 (en) | 1998-11-19 |
| DK0870765T3 (da) | 2004-02-23 |
| TW445260B (en) | 2001-07-11 |
| EP0870765B1 (en) | 2003-11-19 |
| EP0870765A1 (en) | 1998-10-14 |
| CN1184471A (zh) | 1998-06-10 |
| CN1063442C (zh) | 2001-03-21 |
| ES2210366T3 (es) | 2004-07-01 |
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