ATE254609T1 - Aminothiazolderivate, sie enthaltende arzneimittel und zwischenprodukte in der herstellung dieser verbindungen - Google Patents

Aminothiazolderivate, sie enthaltende arzneimittel und zwischenprodukte in der herstellung dieser verbindungen

Info

Publication number
ATE254609T1
ATE254609T1 AT96915167T AT96915167T ATE254609T1 AT E254609 T1 ATE254609 T1 AT E254609T1 AT 96915167 T AT96915167 T AT 96915167T AT 96915167 T AT96915167 T AT 96915167T AT E254609 T1 ATE254609 T1 AT E254609T1
Authority
AT
Austria
Prior art keywords
group
lower alkyl
hydrogen atom
alkyl group
compounds
Prior art date
Application number
AT96915167T
Other languages
English (en)
Inventor
Masaaki Nagasawa
Masakazu Murata
Hiroyasu Nishioka
Tadashi Kurimoto
Shigeru Ueki
Osamu Kitagawa
Original Assignee
Zeria Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeria Pharm Co Ltd filed Critical Zeria Pharm Co Ltd
Application granted granted Critical
Publication of ATE254609T1 publication Critical patent/ATE254609T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT96915167T 1995-05-18 1996-05-16 Aminothiazolderivate, sie enthaltende arzneimittel und zwischenprodukte in der herstellung dieser verbindungen ATE254609T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14239995 1995-05-18
PCT/JP1996/001297 WO1996036619A1 (fr) 1995-05-18 1996-05-16 Derives d'aminothiazole, medicament contenant ces derives et produit intermediaire obtenu durant la production des composes

Publications (1)

Publication Number Publication Date
ATE254609T1 true ATE254609T1 (de) 2003-12-15

Family

ID=15314454

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96915167T ATE254609T1 (de) 1995-05-18 1996-05-16 Aminothiazolderivate, sie enthaltende arzneimittel und zwischenprodukte in der herstellung dieser verbindungen

Country Status (14)

Country Link
US (1) US5981557A (de)
EP (1) EP0870765B1 (de)
JP (1) JP3181919B2 (de)
KR (1) KR100424933B1 (de)
CN (1) CN1063442C (de)
AT (1) ATE254609T1 (de)
AU (1) AU699008B2 (de)
CA (1) CA2219747C (de)
DE (1) DE69630806T2 (de)
DK (1) DK0870765T3 (de)
ES (1) ES2210366T3 (de)
PT (1) PT870765E (de)
TW (1) TW445260B (de)
WO (1) WO1996036619A1 (de)

Families Citing this family (44)

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KR100457240B1 (ko) * 1996-10-24 2004-11-12 제리아 신야쿠 고교 가부시키 가이샤 치환 벤조일아미노티아졸 유도체 및 그것을 함유하는 의약
WO1998058918A1 (fr) * 1997-06-24 1998-12-30 Zeria Pharmaceutical Co., Ltd. Procede de production des derives de 2-hydroxybenzamide
JP2001526028A (ja) 1997-12-11 2001-12-18 スミスクライン・ビーチャム・コーポレイション Ｃ型肝炎ウイルスｎｓ５ｂ末端切断タンパク質およびその抗ウイルス化合物同定方法
SE9803773D0 (sv) * 1998-11-05 1998-11-05 Astra Pharma Prod Compounds
TWI296522B (en) 2000-09-08 2008-05-11 Zeria Pharm Co Ltd Colonic motor dysfunction remedies comprising aminothiazole derivatives as active ingredients
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
EP1493441B1 (de) * 2002-04-08 2011-08-31 Zeria Pharmaceutical Co., Ltd. Therapeutisches mittel für nahrungskompetenzstörungen im magen
US6986901B2 (en) * 2002-07-15 2006-01-17 Warner-Lambert Company Llc Gastrointestinal compositions
US20040010035A1 (en) * 2002-07-15 2004-01-15 Ciociola Arthur A. Gastrointestinal compositions
CA2491797A1 (en) * 2002-07-10 2004-01-22 Warner-Lambert Company Llc Gastrointestinal compositions
GB0412468D0 (en) * 2004-06-04 2004-07-07 Astrazeneca Ab Chemical compounds
CA2838123C (en) * 2004-08-23 2015-05-19 Zeria Pharmaceutical Co., Ltd. Method for producing aminothiazole derivative and production intermediate
AU2011244991B2 (en) * 2004-08-23 2012-08-23 Zeria Pharmaceutical Co., Ltd. Method for producing aminothiazole derivative and production intermediate
US8586761B2 (en) 2004-08-23 2013-11-19 Zeria Pharmaceutical Co., Ltd. Method for producing aminothiazole derivative and production intermediate
US8106048B2 (en) * 2004-09-20 2012-01-31 4Sc Ag Heterocyclic NF-κB inhibitors
CA2581105A1 (en) 2004-09-22 2006-03-30 H. Lundbeck A/S 2-acylaminothiazole derivatives
US7552781B2 (en) 2004-10-20 2009-06-30 Black & Decker Inc. Power tool anti-kickback system with rotational rate sensor
US7674912B2 (en) 2005-04-25 2010-03-09 H. Lundbeck A/S Pro-drugs of N-thiazol-2-yl-benzamide derivatives
KR20080031038A (ko) * 2005-07-29 2008-04-07 4에스체 악티엔게젤샤프트 신규의 헤테로환 ＮＦ-κＢ 억제제
JP2007119416A (ja) * 2005-10-31 2007-05-17 Bayer Cropscience Ag 殺虫性２−アシルアミノチアゾール−４−カルボキサミド類
WO2007116901A1 (ja) * 2006-04-05 2007-10-18 Banyu Pharmaceutical Co., Ltd. 新規アリールアミド誘導体
JP5441052B2 (ja) * 2009-07-16 2014-03-12 ゼリア新薬工業株式会社 アルツハイマー病治療薬
US8418778B2 (en) 2010-01-07 2013-04-16 Black & Decker Inc. Power screwdriver having rotary input control
US9266178B2 (en) 2010-01-07 2016-02-23 Black & Decker Inc. Power tool having rotary input control
US9475180B2 (en) 2010-01-07 2016-10-25 Black & Decker Inc. Power tool having rotary input control
GB2490447A (en) 2010-01-07 2012-10-31 Black & Decker Inc Power screwdriver having rotary input control
CN103204824B (zh) * 2012-01-12 2015-04-08 清华大学深圳研究生院 2-氨基噻唑-4-酰胺类衍生物及其制备方法与应用
EP2631035B1 (de) 2012-02-24 2019-10-16 Black & Decker Inc. Elektrisches Werkzeug
CN103387552B (zh) * 2012-05-10 2016-06-08 常州市第四制药厂有限公司 制备盐酸阿考替胺的方法
CN104447612A (zh) * 2013-09-16 2015-03-25 天津市汉康医药生物技术有限公司 阿考替胺水合物晶型及其制备方法和用途
CN103896873B (zh) * 2013-10-23 2015-11-25 山东诚创医药技术开发有限公司 一种盐酸阿考替胺的精制方法
CN104592147A (zh) * 2013-10-30 2015-05-06 江苏豪森药业股份有限公司 盐酸阿考替胺中间体的制备方法
CN103665023B (zh) * 2013-12-23 2017-05-24 华润赛科药业有限责任公司 一种盐酸阿考替胺的合成方法
CN103980226A (zh) * 2014-05-10 2014-08-13 杭州新博思生物医药有限公司 盐酸阿考替胺水合物晶型及其制备方法
CN104031001B (zh) * 2014-06-30 2015-09-30 山东诚创医药技术开发有限公司 一锅烩制备2-[n-(2,4,5-三甲氧基苯甲胺基)氨基]-4-乙氧羰基-1,3-噻唑的方法
CN104130207B (zh) * 2014-07-07 2016-08-24 湖北华世通生物医药科技有限公司 阿考替胺氢溴酸盐水合物及其晶型的制备方法
CN105439977A (zh) * 2014-09-26 2016-03-30 广州朗圣药业有限公司 一种阿考替胺及其盐酸盐的制备方法
CN105924406B (zh) * 2016-05-04 2018-04-10 河北国龙制药有限公司 一种盐酸阿考替胺三水合物的制备方法
US10589413B2 (en) 2016-06-20 2020-03-17 Black & Decker Inc. Power tool with anti-kickback control system
KR102453655B1 (ko) * 2017-10-25 2022-10-12 (주)헥사파마텍 아코티아미드의 개선된 제조방법
CN108358867A (zh) * 2018-05-05 2018-08-03 邳州易萨新型材料有限公司 一种盐酸阿考替胺的合成方法
CN109776447B (zh) * 2019-02-28 2021-03-02 常州市阳光药业有限公司 盐酸阿考替胺工业化生产方法
CN109988121B (zh) * 2019-04-28 2023-01-03 梯尔希（南京）药物研发有限公司 一种阿考替胺衍生物的制备方法
CN111518052A (zh) * 2020-05-27 2020-08-11 廊坊市泽康医药科技有限公司 一种阿考替胺盐酸盐杂质的制备方法

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US4829073A (en) * 1988-05-12 1989-05-09 Bristol-Myers Company Thiadiazole oxides for treating gastrointestinal motility disorders
JPH0730064B2 (ja) * 1989-08-17 1995-04-05 協和醗酵工業株式会社 フラン誘導体
US5424431A (en) * 1990-10-24 1995-06-13 Yamanouchi Pharmaceutical Co., Ltd. Thiazole derivatives
JP3029876B2 (ja) * 1991-03-05 2000-04-10 協和醗酵工業株式会社 フラン誘導体
JPH1135565A (ja) * 1993-10-25 1999-02-09 Zeria Pharmaceut Co Ltd チアゾール誘導体、それを含有する医薬および該化合物の製造中間体
US5510478A (en) * 1994-11-30 1996-04-23 American Home Products Corporation 2-arylamidothiazole derivatives with CNS activity
US5712270A (en) * 1995-11-06 1998-01-27 American Home Products Corporation 2-arylamidothiazole derivatives with CNS activity

Also Published As

Publication number Publication date
KR19990008282A (ko) 1999-01-25
DE69630806D1 (de) 2003-12-24
EP0870765A4 (de) 1998-10-14
CA2219747A1 (en) 1996-11-21
AU699008B2 (en) 1998-11-19
DK0870765T3 (da) 2004-02-23
AU5702496A (en) 1996-11-29
KR100424933B1 (ko) 2004-07-27
EP0870765B1 (de) 2003-11-19
JP3181919B2 (ja) 2001-07-03
US5981557A (en) 1999-11-09
EP0870765A1 (de) 1998-10-14
WO1996036619A1 (fr) 1996-11-21
CA2219747C (en) 2008-11-25
PT870765E (pt) 2004-03-31
TW445260B (en) 2001-07-11
DE69630806T2 (de) 2004-04-15
CN1063442C (zh) 2001-03-21
ES2210366T3 (es) 2004-07-01
CN1184471A (zh) 1998-06-10

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