ES8700857A1 - Un procedimiento para la produccion de dihidropiridinas - Google Patents

Un procedimiento para la produccion de dihidropiridinas

Info

Publication number
ES8700857A1
ES8700857A1 ES543999A ES543999A ES8700857A1 ES 8700857 A1 ES8700857 A1 ES 8700857A1 ES 543999 A ES543999 A ES 543999A ES 543999 A ES543999 A ES 543999A ES 8700857 A1 ES8700857 A1 ES 8700857A1
Authority
ES
Spain
Prior art keywords
ischaemic
ch2ch
het
alkyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543999A
Other languages
English (en)
Other versions
ES543999A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp
Original Assignee
Pfizer Corp Belgium
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848414520A external-priority patent/GB8414520D0/en
Priority claimed from GB858508736A external-priority patent/GB8508736D0/en
Application filed by Pfizer Corp Belgium, Pfizer Corp filed Critical Pfizer Corp Belgium
Publication of ES543999A0 publication Critical patent/ES543999A0/es
Publication of ES8700857A1 publication Critical patent/ES8700857A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DIHIDROPIRIDINAS, DE FORMULA (I), Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES. COMPRENDE LA REACCION DE UNA SAL SODICA O POTASICA DE UN COMPUESTO DE FORMULA (II), CON UN COMPUESTO DE FORMULA HET.Q PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LAS QUE Q ES UN GRUPO SALIENTE, HET REPRESENTA A UN GRUPO HETEROCICLICO AROMATICO DE 5 O 6 MIEMBROS, R ES ARILO O HETEROARILO, R1 Y R2 SON ALQUEILO C1-4 O 2-METOXIETILO, E Y PUEDE SER VARIOS RADICALES. LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO INERTE A UNA TEMPERATURA ENTRE LA AMBIENTE Y 100JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIISQUEMICOS Y ANTIHIPERTENSIVOS.
ES543999A 1984-06-07 1985-06-07 Un procedimiento para la produccion de dihidropiridinas Expired ES8700857A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848414520A GB8414520D0 (en) 1984-06-07 1984-06-07 Dihydropyridines
GB858508736A GB8508736D0 (en) 1985-04-03 1985-04-03 Dihydropyridines

Publications (2)

Publication Number Publication Date
ES543999A0 ES543999A0 (es) 1986-11-16
ES8700857A1 true ES8700857A1 (es) 1986-11-16

Family

ID=26287832

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543999A Expired ES8700857A1 (es) 1984-06-07 1985-06-07 Un procedimiento para la produccion de dihidropiridinas

Country Status (14)

Country Link
US (1) US4618609A (es)
EP (1) EP0164247B1 (es)
JP (1) JPH0641464B2 (es)
AU (1) AU556496B2 (es)
DE (1) DE3567460D1 (es)
DK (1) DK170402B1 (es)
ES (1) ES8700857A1 (es)
FI (1) FI852222L (es)
GR (1) GR851383B (es)
HU (1) HUT41404A (es)
IE (1) IE57816B1 (es)
IL (1) IL75411A0 (es)
PL (1) PL253821A1 (es)
PT (1) PT80597B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8412208D0 (en) * 1984-05-12 1984-06-20 Pfizer Ltd Quinolone inotropic agents
HU199796B (en) * 1985-08-06 1990-03-28 Boehringer Biochemia Srl Process for producing 2-thiomethyl-substituted-1,4-dihydropyridines and pharmaceutical compositions comprising such compounds
GB8527698D0 (en) * 1985-11-09 1985-12-11 Pfizer Ltd Dihydropyridine antiischaemic & antihypertensive agents
US4761420A (en) * 1986-06-13 1988-08-02 Laboratoires Syntex S.A. Antihypertensive dihydropyridine derivatives
US4920134A (en) * 1987-08-07 1990-04-24 Takeda Chemical Industries, Ltd. 2-O-pyrimidinyl glycerol derivatives
US5424321A (en) * 1993-12-08 1995-06-13 Alcon Laboratories, Inc. Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents
US5691360A (en) * 1993-12-08 1997-11-25 Alcon Laboratories, Inc. Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents
AU2004315596B2 (en) * 2003-08-29 2011-11-24 President And Fellows Of Harvard College Inhibitors of cellular necrosis
WO2010075290A1 (en) * 2008-12-22 2010-07-01 President And Fellows Of Harvard College Unsaturated heterocyclic inhibitors of necroptosis
EP2381775A4 (en) 2008-12-23 2012-08-15 Harvard College INHIBITORS OF NECROPTOSIS OF SMALL MOLECULAR SIZE
EP2968276A4 (en) 2013-03-15 2017-02-15 President and Fellows of Harvard College Hybrid necroptosis inhibitors
WO2016094846A1 (en) 2014-12-11 2016-06-16 President And Fellows Of Harvard College Inhibitors of cellular necrosis and related methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2951945A1 (de) * 1979-12-22 1981-07-02 Ibm Deutschland Gmbh, 7000 Stuttgart Schaltungsanordnung zur kapazitiven lesesignalverstaerkung in einem integrierten halbleiterspeicher mit einem intergrierten halbleiterspeicher mit speicherzellen in mtl-technik
DE3363743D1 (en) * 1982-07-22 1986-07-03 Pfizer Ltd Dihydropyridine anti-ischaemic and antihypertensive agents
PL140069B1 (en) * 1982-12-21 1987-03-31 Pfizer Method of obtaining new derivatives of dihydropiridine
US4515799A (en) * 1983-02-02 1985-05-07 Pfizer Inc. Dihydropyridine anti-ischaemic and antihypertensive agents

Also Published As

Publication number Publication date
HUT41404A (en) 1987-04-28
DE3567460D1 (en) 1989-02-16
FI852222L (fi) 1985-12-08
FI852222A0 (fi) 1985-06-03
IL75411A0 (en) 1985-10-31
JPH0641464B2 (ja) 1994-06-01
JPS611685A (ja) 1986-01-07
IE57816B1 (en) 1993-04-21
ES543999A0 (es) 1986-11-16
DK253785D0 (da) 1985-06-06
DK170402B1 (da) 1995-08-21
DK253785A (da) 1985-12-08
PL253821A1 (en) 1986-07-01
EP0164247A1 (en) 1985-12-11
GR851383B (es) 1985-11-25
PT80597A (en) 1985-07-01
AU4334985A (en) 1985-12-12
EP0164247B1 (en) 1989-01-11
PT80597B (en) 1987-04-23
US4618609A (en) 1986-10-21
IE851417L (en) 1985-12-07
AU556496B2 (en) 1986-11-06

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