KR910000648A - 페녹시피리딘아민 및 이의 유도체, 제조방법 및 약제로서의 용도 - Google Patents

페녹시피리딘아민 및 이의 유도체, 제조방법 및 약제로서의 용도 Download PDF

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KR910000648A
KR910000648A KR1019900009608A KR900009608A KR910000648A KR 910000648 A KR910000648 A KR 910000648A KR 1019900009608 A KR1019900009608 A KR 1019900009608A KR 900009608 A KR900009608 A KR 900009608A KR 910000648 A KR910000648 A KR 910000648A
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South Korea
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lower alkyl
compound
formula
hydrogen
defined below
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KR1019900009608A
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챨스 에프랜드 리챠드
토마스 클라인 죠셉
에드워드 올센 고돈
데이비스 래리
Original Assignee
도날드 알.토르센
훽스트-러셀 파마슈티칼즈 인코포레이티드
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Publication of KR910000648A publication Critical patent/KR910000648A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

페녹시피리딘아민 및 이의 유도체, 제조방법 및 약제로서의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 일반식(Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 산부가염.
    상기식에서, n은 0또는 1이며, x는 수소, 저급알킬, 저급 알콕시, 할로겐, 포르밀, 저급알킬 카보닐, 저급 알콕시 카보닐, 저급 알콕시카보닐 저급알킬 또는 하이드록시메틸이고, Y는 수소 또는 할로겐이여, Z은 NO2또는 NHR이고 R은 수소, 저급알킬 아릴 저급알킬 또는 저급알킬 카보닐이다.
  2. 제1항에 있어서, Y가 수소이고, R이 수소 또는 저급알킬 카보닐인 화합물.
  3. 제1항에 있어서, 3-(4-메톡시페녹시)-4-니트로피리딘-1-옥사이드 또는 이의 약제학적으로 허용되는 산부가염.
  4. 제1항에 있어서, 3-페녹시-4-피리딘아민 또는 이의 약제학적으로 허용되는 산부가염.
  5. 제1항에 있어서, 4-(4-아미노-3-피리디닐옥시)벤젠아세트산 에틸 에스테르 또는 이의 약제학적으로 허용되는 산부가염.
  6. 제1항에 있어서, 4-페녹시-3-피리딘아민 또는 이의 약제학적으로 허용되는 산부가염.
  7. 활성성분인 제1항에서 정의한 화합물 및 이의 적합한 담체를 함유함을 특징으로 하는 약제학적 조성물.
  8. 피부병의 치료에 유효한 약제를 제조하기 위한, 제1항에서 정의한 화합물의 용도.
  9. 하기 일반식(Ⅲ)의 화합물을 하기 일반식(Ⅳ)의 화합물과 반응시켜, Z가 NO2이고 n, x 및 Y는 하기 정의한 바와 같은 일반식(Ⅰ)의 화합물을 생성시키고, 임의로는, n이 1이고 Z가 NO2이며 X 및 Y가 하기 정의한 바와 같은 일반식(Ⅰ)의 화합물을 선택적으로 수소화시켜, n이 1이고 Z가 NH2이며 X 및 Y가 하기 정의한 바와 같은 일반식(Ⅰ)의 화합물을 생성시키고, 임의로는 n이 1이고 Z가 NO2또는 NH2이며 X 및 Y가 하기 정의한 바와 같은 일반식(Ⅰ)의 화합물을 촉매적으로 수소화시켜, n이 0이고 Z가 NH2이며 X 및 Y가 하기 정의한 바와 같은 일반식(Ⅰ)의 화합물을 생성시키고, 임의로는 Z가 NH2이며 n,x 및 Y가 하기 정의한 바와 같은 일반식(Ⅰ)의 화합물을 일반식R-Haℓ(여기서, R은 저급 알킬, 아릴 저급알킬 또는 저급 알킬 카보닐이며, Haℓ은 Cℓ또는 Br이다)의 화합물과 반응시켜, Z가 NHR이고 R1, n,x 및 Y가 하기 정의한 바와 같은 일반식(Ⅰ)의 화합물을 생성시키고, 임의로는, n이 1이고 Z가 NO2이며 X가 -CHO이고 Y는 하기 정의한 바와 같은 일반식(Ⅰ)의 화합물을 수소화시켜, n이 0이고 Z가 NH2이며 X가 -CH2OH이고 Y가 하기 정의한 바와 같은 일반식(Ⅰ)의 화합물을 생성시킴을 특징으로 하여, 제1항에서 정의한 일반식(Ⅰ)의 화합물을 제조하는 방법.
    상기식에서, n은 0또는 1이며, x는 수소, 저급알킬, 저급알콕시, 할로겐, 포르밀, 저급알킬 카보닐, 저급알콕시카보닐, 저급알콕시카보닐 저급알킬 또는 하이드록시메틸이고, Y는 수소 또는 할로겐이며, Z은 NO2또는 NHR이고, R은 수소, 저급알킬, 아릴 저급 알킬 또는 저급 알킬 카보닐이며, Haℓ은 F또는 Cℓ이고, M은 수소, 또는 Li, Nz또는 K이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900009608A 1989-06-29 1990-06-28 페녹시피리딘아민 및 이의 유도체, 제조방법 및 약제로서의 용도 KR910000648A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/372,970 US4959377A (en) 1989-06-29 1989-06-29 Phenoxypyridinamine compounds which are use as a dermatological composition
US372970 1989-06-29

Publications (1)

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KR910000648A true KR910000648A (ko) 1991-01-29

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US (1) US4959377A (ko)
EP (1) EP0405487A1 (ko)
JP (1) JPH0338568A (ko)
KR (1) KR910000648A (ko)
AU (1) AU5791290A (ko)
CA (1) CA2020088A1 (ko)
FI (1) FI903237A0 (ko)
IE (1) IE902349A1 (ko)
IL (1) IL94894A0 (ko)
NO (1) NO902890L (ko)
PT (1) PT94523A (ko)
ZA (1) ZA905045B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4405641C2 (de) * 1994-02-22 1997-04-30 Roemmers Sa Pharmazeutische Zusammensetzung, enthaltend 2-(4-Methoxyphenoxy)-3-pyridinamin
DE4432106A1 (de) * 1994-09-09 1996-03-14 Hoechst Ag Mit Heterocyclen-N-Oxid-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum, sie enthaltendes Medikament sowie Zwischenprodukte zu ihrer Herstellung
US6455554B1 (en) 1999-06-07 2002-09-24 Targacept, Inc. Oxopyridinyl pharmaceutical compositions and methods for use
EP2606884A1 (en) * 2011-12-21 2013-06-26 Ecole Polytechnique Fédérale de Lausanne (EPFL) Inhibitors of notch signaling pathway and use thereof in treatment of cancers

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2103017A (en) * 1930-10-23 1937-12-21 Winthrop Chem Co Inc Basic derivatives of cyclic etherlike compounds
US3118884A (en) * 1959-10-19 1964-01-21 Schering Corp Derivatives of 3-azaphenothiazine and 3-azaphenoxazine
US3495969A (en) * 1967-09-25 1970-02-17 Mobil Oil Corp Substituted nitropyridines as herbicides
US3539639A (en) * 1967-11-22 1970-11-10 Merck & Co Inc Certain pyridinoxy or pyridine thio-salicyl anilides and n-phenoxy-pyridyl salicylamides
US3576616A (en) * 1969-05-15 1971-04-27 Monsanto Co Herbicidal compositions and methods
US3721676A (en) * 1969-11-12 1973-03-20 Merck & Co Inc Certain 3-amino-2(1h)pyridones
GB2073736B (en) * 1979-10-03 1984-02-01 Ici Ltd Process for preparing pyridinyloxyphenoxy compounds and derivatives thereof
IE56702B1 (en) * 1982-12-01 1991-11-06 Usv Pharma Corp Antiinflammatory antiallergic compounds

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IE902349L (en) 1990-12-29
IL94894A0 (en) 1991-04-15
AU5791290A (en) 1991-02-14
US4959377A (en) 1990-09-25
PT94523A (pt) 1991-02-08
IE902349A1 (en) 1991-01-16
NO902890L (no) 1991-01-02
JPH0338568A (ja) 1991-02-19
FI903237A0 (fi) 1990-06-27
ZA905045B (en) 1991-03-27
NO902890D0 (no) 1990-06-28
EP0405487A1 (en) 1991-01-02
CA2020088A1 (en) 1990-12-30

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