KR910002450A - 당뇨병 치료용 제약 조성물 - Google Patents

당뇨병 치료용 제약 조성물 Download PDF

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Publication number
KR910002450A
KR910002450A KR1019900011313A KR900011313A KR910002450A KR 910002450 A KR910002450 A KR 910002450A KR 1019900011313 A KR1019900011313 A KR 1019900011313A KR 900011313 A KR900011313 A KR 900011313A KR 910002450 A KR910002450 A KR 910002450A
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KR
South Korea
Prior art keywords
pharmaceutical composition
compound
formula
independently
alkyl group
Prior art date
Application number
KR1019900011313A
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English (en)
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KR0171189B1 (ko
Inventor
맥도날드 로빈슨 케이스
젠 탄 마오 시몬
리 잭슨 리차드
앨란 파커 로저
Original Assignee
게리 디.스트리트
메렐 다우 파마슈티칼스 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 게리 디.스트리트, 메렐 다우 파마슈티칼스 인크. filed Critical 게리 디.스트리트
Publication of KR910002450A publication Critical patent/KR910002450A/ko
Application granted granted Critical
Publication of KR0171189B1 publication Critical patent/KR0171189B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/065—Diphenyl-substituted acyclic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

내용 없음

Description

당뇨병 치료용 제약 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 치료학적으로 유효한 혈당 저하량의 하기 일반식(I)의 화합물과 제약상 허용되는 담체 또는 부형제로 이루어진 혈당 저하용 제약 조성물.
    상기식에서, R1, R2, R3및 R4는 각각 독립적으로 C1-C6알킬기이다.
  2. 치료학적으로 유효한 혈당 저하량의 하기 일반식(I)의 화합물과 제약상 허용되는 담체 또는 부형제로 이루어진 당뇨병 환자 치료용 제약 조성물.
    상기식에서, R1, R2, R3및 R4는 각각 독립적으로 C1-C6알킬기이다.
  3. 제1항 또는 2항에 있어서, 상기 화합물이 4,4'-비스(2,6-디-tert, 부틸-페놀)인 제약 조성물.
  4. (a) 다음 일반식(II) 및 (III) 의 2,6-디-알킬페놀류를 알칼리토금속으로 된 염기 존재하에서 페리시아나이드염과 반응시킨 후, (b) 이와 같이 형성된 3,3', 5,5'-테트라-알킬-디페노퀴논을 유기산존재하에서 아연을 사용하여 환원시키는 단계로 이루어진 하기 일반식(I)의 화합물의 제조방법
    상기식에서, R1, R2, R3및 R4는 각각 독립적으로 C1-C6알킬기이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900011313A 1989-07-26 1990-07-25 당뇨병 치료용 제약 조성물 KR0171189B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/385,623 US5001282A (en) 1989-07-26 1989-07-26 Method of treating diabetes mellitus with bisphenol derivatives
US07/385623 1989-07-26
US385,623 1989-07-26

Publications (2)

Publication Number Publication Date
KR910002450A true KR910002450A (ko) 1991-02-25
KR0171189B1 KR0171189B1 (ko) 1999-02-01

Family

ID=23522194

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900011313A KR0171189B1 (ko) 1989-07-26 1990-07-25 당뇨병 치료용 제약 조성물

Country Status (11)

Country Link
US (1) US5001282A (ko)
EP (1) EP0410343B1 (ko)
JP (2) JP2954989B2 (ko)
KR (1) KR0171189B1 (ko)
AT (1) ATE126432T1 (ko)
AU (1) AU623794B2 (ko)
DE (1) DE69021664T2 (ko)
DK (1) DK0410343T3 (ko)
IE (1) IE68040B1 (ko)
PH (1) PH27117A (ko)
ZA (1) ZA905736B (ko)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6752218B2 (en) 1999-01-08 2004-06-22 Pnm, Inc. Fire protection sprinkler head support
US10500427B2 (en) 2014-06-27 2019-12-10 Anvil International, Llc Adjustable bracket and hub for flexible hose support

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4519283B2 (ja) * 2000-07-17 2010-08-04 独立行政法人産業技術総合研究所 新規なフェノール二量体縮合物
CA2553710A1 (en) * 2004-01-15 2005-07-28 Aska Pharmaceutical Co., Ltd. Abca1 stabilizer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115590A (en) * 1964-02-26 1978-09-19 Ethyl Corporation Binuclear phenols for reducing plasma lipid levels
US3549712A (en) * 1968-01-12 1970-12-22 Gen Electric Coupling of phenols with quinol ethers
US4049731A (en) * 1975-07-14 1977-09-20 Ici United States Inc. Stabilized polymerizable compositions
US4361708A (en) * 1981-03-06 1982-11-30 The Dow Chemical Company Formation of biphenols
US4410736A (en) * 1981-04-06 1983-10-18 The Dow Chemical Company Coupling of phenols with diphenoquinones

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6752218B2 (en) 1999-01-08 2004-06-22 Pnm, Inc. Fire protection sprinkler head support
US7032680B2 (en) 1999-01-08 2006-04-25 Pnm, Inc. Fire protection sprinkler head support
US10500427B2 (en) 2014-06-27 2019-12-10 Anvil International, Llc Adjustable bracket and hub for flexible hose support

Also Published As

Publication number Publication date
DE69021664D1 (de) 1995-09-21
JPH0358922A (ja) 1991-03-14
AU623794B2 (en) 1992-05-21
JPH11343256A (ja) 1999-12-14
ZA905736B (en) 1991-05-29
DK0410343T3 (da) 1995-09-18
US5001282A (en) 1991-03-19
ATE126432T1 (de) 1995-09-15
KR0171189B1 (ko) 1999-02-01
IE68040B1 (en) 1996-05-15
DE69021664T2 (de) 1996-02-01
JP2954989B2 (ja) 1999-09-27
EP0410343B1 (en) 1995-08-16
EP0410343A3 (en) 1992-04-29
EP0410343A2 (en) 1991-01-30
PH27117A (en) 1993-03-16
AU5973990A (en) 1991-01-31

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