KR870006040A - 치환된 4-플루오로-이소인돌린, 그의 제조방법과 용도 및 이들을 함유하는 제제 - Google Patents

치환된 4-플루오로-이소인돌린, 그의 제조방법과 용도 및 이들을 함유하는 제제 Download PDF

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KR870006040A
KR870006040A KR860011090A KR860011090A KR870006040A KR 870006040 A KR870006040 A KR 870006040A KR 860011090 A KR860011090 A KR 860011090A KR 860011090 A KR860011090 A KR 860011090A KR 870006040 A KR870006040 A KR 870006040A
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fluoro
compound
isoindolin
formula
amino
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KR860011090A
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코넨 에리히
아르마 벤
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빈프리트 그류츄너. 에르렌트 딘네.
바이어스도르프 악티엘게젤샤프트
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Publication of KR870006040A publication Critical patent/KR870006040A/ko

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A—HUMAN NECESSITIES
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Abstract

내용 없음

Description

치환된 4-플루오로-이소인돌린, 그의 제조방법과 용도 및 이들을 함유하는 제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 일반식(I)의 치환된 4-플루오로-이소인들린 및 이들의 이성질체 및 이들의 산부가염:
    상기 식에서, R은 수소 또는 아실기를 나타낸다.
  2. 4-플루오로-2-(2-이미다졸린-2-일아미노)-이소인돌린.
  3. 4-플루오로-2-(1-아세틸-2-이미다졸린)-2-일아미노)-이소인돌린.
  4. 제1항에 있어서, 아실기 R이 치환되거나 비치환된 알킬카르보닐, 시클로알킬카르보닐 및 아로일기임을 특징으로 하는 화합물.
  5. 2-아미노-4-플루오로-이소인돌린.
  6. 2-아미노-4-플루오로-이소인돌린을 다음식(Ⅱ)의 화합물과 반응시킴믈 특징으로 하는 제1항에 따른 식(I)의 화합물의 제조방법.
    상기 식에서, R은 상기에 정의한 바와 같고, R1은 친핵적으로 치환될 수 있는 기이고, R이 수소를 나타내는 화합물을 제조하기 위해 아실기는 분열된다.
  7. 2-아미노-4-플루오로-이소인돌린을 다음 식(Ⅲ)의 화합물과 반응시킴을 특징으로 하는 제1항에 따른 식(I)의 화합물의 제조방법.
    상기식에서, R은 상기에 언급한 것과 같고, R이 수소를 나타내는 화합물을 제조하기 위해 아실기는 분열된다.
  8. 4-플루오로-2-(2-이미다졸린-2-일아미노)-이소이돌린을 아실기 R을 함유하는 아실화제와 반응시킴을 특징으로 하는 제1항에 따른 식(I)의 아실화합물의 제조방법.
  9. 3-플루오로-프탈산 무수물을 3차-부틸 카르바제이트와 반응시키고, 얻어진 치환된 프탈아미드를 환원시켜 해당하는 치환된 이소인돌린으로 전환시키고, 이로부터 3차-부톡시카르보닐기를 분열시켜 2-아미노-4-플루오로-이소인돌린을 얻음을 특징으로 2-아미노-4-플루오로-이소인돌린의 제조방법.
  10. 하나 또는 그 이상의 제1항에 따른 화합물 또는 제약에 수용할 수 있는 그의 염 및 적당하다면 통상적인 부형제 및/또는 희석제를 함유함을 특징으로 하는 제약 제제.
  11. 특히, 고혈압, 관상동맥질병, 편두통, 협심증, 레이노병, 천신 및 대사성질별, 당뇨병, 비만증, 녹내장 및 혈전색전증의 치료를 위해 치료 활성화합물로써 유용한 제1항에 따른 식(I)의 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR860011090A 1985-12-20 1986-12-20 치환된 4-플루오로-이소인돌린, 그의 제조방법과 용도 및 이들을 함유하는 제제 KR870006040A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3545206.4 1985-12-20
DE19853545206 DE3545206A1 (de) 1985-12-20 1985-12-20 Substituierte 4-fluor-isoindoline, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen

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KR870006040A true KR870006040A (ko) 1987-07-08

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KR860011090A KR870006040A (ko) 1985-12-20 1986-12-20 치환된 4-플루오로-이소인돌린, 그의 제조방법과 용도 및 이들을 함유하는 제제

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US (1) US4777181A (ko)
JP (2) JPS62155272A (ko)
KR (1) KR870006040A (ko)
DE (1) DE3545206A1 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726197A (en) * 1992-11-02 1998-03-10 Syntex (U.S.A.) Inc. Isoindolinyl derivatives
US5677321A (en) * 1996-02-29 1997-10-14 Synaptic Pharmaceutical Corporation 5- and 6-(2-imidazolin-2-ylamino) and -(2-thiazolin-2-ylamino)-benzothiazoles as alpha-2 adrenergic ligands
US7121728B2 (en) * 2004-08-04 2006-10-17 Gunite Corporation Seal for a bearing assembly
JP5022000B2 (ja) 2006-10-24 2012-09-12 株式会社ジェイテクト 密封装置および転がり軸受装置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2905501A1 (de) * 1979-02-14 1980-08-28 Beiersdorf Ag Neue kondensierte, stickstoffhaltige heterocyclische verbindungen und verfahren zu deren herstellung
DE2816627A1 (de) * 1978-04-17 1979-10-25 Beiersdorf Ag 2-(n-amino-isoindolinyl)-imidazolin und verfahren zu seiner herstellung
JPS54151990A (en) * 1978-04-17 1979-11-29 Beiersdorf Ag Novel condensated nitrogenncontained heterocyclic compound and its manufacture
DE3133302A1 (de) * 1981-08-22 1983-03-03 Beiersdorf Ag, 2000 Hamburg Isoindolin-2-yl-amino-imidazoline und isoindolin-2-yl-guanidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

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JPS62158216A (ja) 1987-07-14
JPS62155272A (ja) 1987-07-10
US4777181A (en) 1988-10-11
DE3545206A1 (de) 1987-06-25

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