KR890005086A - 1-[(2- 피리미디닐) 아미노알킬]피페리딘, 그의 제법 및 치료에의 이용 - Google Patents

1-[(2- 피리미디닐) 아미노알킬]피페리딘, 그의 제법 및 치료에의 이용 Download PDF

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Publication number
KR890005086A
KR890005086A KR1019880011600A KR880011600A KR890005086A KR 890005086 A KR890005086 A KR 890005086A KR 1019880011600 A KR1019880011600 A KR 1019880011600A KR 880011600 A KR880011600 A KR 880011600A KR 890005086 A KR890005086 A KR 890005086A
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South Korea
Prior art keywords
compound
group
formula
atom
hydrogen
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KR1019880011600A
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English (en)
Inventor
마누리 필리쁘
사아르멧 알프레드
Original Assignee
에. 뚜레 레메뜨르
신떼라보 소시에떼 아노님
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Application filed by 에. 뚜레 레메뜨르, 신떼라보 소시에떼 아노님 filed Critical 에. 뚜레 레메뜨르
Publication of KR890005086A publication Critical patent/KR890005086A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

내용 없음

Description

1-[(2-피리미디닐)아미노알킬]피페리딘, 그의 제법 및 치료에의 이용
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 다음식(I)에 해당하는 피페리딘의 피리미디닐아미노 유도체, 및 약제학적으로 허용되는 산과의 그의 부가염.
    상기식에서, X는 (CH2)2, CH=CH 또는 CH2-CO기를 나타내며, Y는 CH=CH기 또는 황원자를 나타내며, n은 2,3 또는 4이고, R1은 수소 또는 할로겐원자이며, R2는 수소원자 또는 (C1-4)알킬기이고, R3는 수소 원자 또는 히드록시기이다.
  2. 다음식 (II)
    의 화합물을 80 내지 130℃의 온도에서, 메틸 이소 부틸 케톤과 같은 용매에서 식 R(CH2)nZ(여기서 Z는 불안정기이며 R은 프탈이미도 또는 N(Alk)(트리틸)기, Alk는 (C1-4)알킬이다)의 화합물과 반응시킨 다음, 화합물(III)
    을 히드라진과 반응시켜 화합물(V)
    를 얻거나, 아니면 화합물(IV)
    을 화합물(VI)
    로 가수분해시키고 최종적으로 화합물(V) 또는 (VI)을 80 내지 130℃의 온도에서 메틸 이소부틸 케톤과 같은 용매에서 식 (VII)
    의 화합물과 반응시켜 화합물(I)을 얻는 것을 특징으로 하는 제1항에 따르는 화합물이 제조방법.
  3. 제1항에 명시된 것과 같은 화합물을 함유하는 것을 특징으로 하는 의약생성물.
  4. 어떤 적합한 부형제와 조합하여 제1항에 명시된 화합물을 함유하는 것을 특징으로 하는 약학조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880011600A 1987-09-09 1988-09-08 1-[(2- 피리미디닐) 아미노알킬]피페리딘, 그의 제법 및 치료에의 이용 KR890005086A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8712502A FR2620121B1 (fr) 1987-09-09 1987-09-09 ((pyrimidinyl-2)-aminoalkyl)-1 piperidines, leur preparation et leur application en therapeutique
FR87.12502 1987-09-09

Publications (1)

Publication Number Publication Date
KR890005086A true KR890005086A (ko) 1989-05-11

Family

ID=9354744

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880011600A KR890005086A (ko) 1987-09-09 1988-09-08 1-[(2- 피리미디닐) 아미노알킬]피페리딘, 그의 제법 및 치료에의 이용

Country Status (18)

Country Link
US (2) US4891376A (ko)
EP (1) EP0307303B1 (ko)
JP (1) JPH01104069A (ko)
KR (1) KR890005086A (ko)
AT (1) ATE70062T1 (ko)
AU (1) AU603004B2 (ko)
DE (1) DE3866646D1 (ko)
DK (1) DK499088A (ko)
ES (1) ES2040879T3 (ko)
FI (1) FI884132A (ko)
FR (1) FR2620121B1 (ko)
GR (1) GR3003481T3 (ko)
HU (1) HU199141B (ko)
IL (1) IL87609A (ko)
NO (1) NO883994L (ko)
NZ (1) NZ226089A (ko)
PT (1) PT88460B (ko)
ZA (1) ZA886698B (ko)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2618436B1 (fr) * 1987-07-23 1989-10-27 Synthelabo Derives de piperidine, leur preparation et leur application en therapeutique
US5250681A (en) * 1988-06-02 1993-10-05 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same
US5231104A (en) * 1988-07-08 1993-07-27 Pfizer Inc. 1-arylethyl-3-substituted piperidines
FR2678271B1 (fr) * 1991-06-27 1995-01-13 Synthelabo Derives de pyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
KR100351012B1 (ko) * 1994-04-20 2002-12-26 아지노모토 가부시키가이샤 피페리딘유도체및이를함유하는항혈소판제
JP3779349B2 (ja) * 1995-04-24 2006-05-24 興和株式会社 ピペリジン誘導体
JP2914324B2 (ja) 1995-10-23 1999-06-28 味の素株式会社 ピペリジン誘導体の結晶並びにその製造中間体及び製造方法
US5869497A (en) * 1996-03-15 1999-02-09 Eli Lilly And Company Method of treating or ameliorating the symptoms of common cold or allergic rhinitis
US7941675B2 (en) * 2002-12-31 2011-05-10 Burr James B Adaptive power control
US7112978B1 (en) 2002-04-16 2006-09-26 Transmeta Corporation Frequency specific closed loop feedback control of integrated circuits
US7949864B1 (en) * 2002-12-31 2011-05-24 Vjekoslav Svilan Balanced adaptive body bias control
US7228242B2 (en) 2002-12-31 2007-06-05 Transmeta Corporation Adaptive power control based on pre package characterization of integrated circuits
US7953990B2 (en) * 2002-12-31 2011-05-31 Stewart Thomas E Adaptive power control based on post package characterization of integrated circuits
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
US7129771B1 (en) 2003-12-23 2006-10-31 Transmeta Corporation Servo loop for well bias voltage source
US7692477B1 (en) 2003-12-23 2010-04-06 Tien-Min Chen Precise control component for a substrate potential regulation circuit
US7012461B1 (en) 2003-12-23 2006-03-14 Transmeta Corporation Stabilization component for a substrate potential regulation circuit
US7649402B1 (en) * 2003-12-23 2010-01-19 Tien-Min Chen Feedback-controlled body-bias voltage source
US7774625B1 (en) 2004-06-22 2010-08-10 Eric Chien-Li Sheng Adaptive voltage control by accessing information stored within and specific to a microprocessor
MX2010008400A (es) * 2008-01-30 2010-08-23 Nippon Zoki Pharmaceutical Co Derivado de piperidina.
JP5083989B2 (ja) * 2008-11-20 2012-11-28 日本臓器製薬株式会社 ピペリジン誘導体を含有する医薬
US9296731B2 (en) * 2011-06-28 2016-03-29 Fujian Mindong Rejuvenation Pharmaceutical Co., Ltd. Anti-allergy benzocycloheptathiophene derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254127A (en) * 1980-04-03 1981-03-03 Janssen Pharmaceutica, N.V. 1,3-Dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives

Also Published As

Publication number Publication date
DE3866646D1 (de) 1992-01-16
EP0307303A1 (fr) 1989-03-15
DK499088A (da) 1989-04-03
US4929621A (en) 1990-05-29
NO883994L (no) 1989-03-10
NO883994D0 (no) 1988-09-08
JPH01104069A (ja) 1989-04-21
FR2620121B1 (fr) 1990-01-05
FI884132A (fi) 1989-03-10
FR2620121A1 (fr) 1989-03-10
GR3003481T3 (en) 1993-02-17
AU2201088A (en) 1989-03-23
DK499088D0 (da) 1988-09-08
ZA886698B (en) 1989-04-26
IL87609A (en) 1992-09-06
EP0307303B1 (fr) 1991-12-04
NZ226089A (en) 1990-06-26
PT88460B (pt) 1992-11-30
US4891376A (en) 1990-01-02
PT88460A (pt) 1988-10-01
FI884132A0 (fi) 1988-09-08
AU603004B2 (en) 1990-11-01
ATE70062T1 (de) 1991-12-15
HUT47927A (en) 1989-04-28
IL87609A0 (en) 1989-01-31
ES2040879T3 (es) 1993-11-01
HU199141B (en) 1990-01-29

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