KR860002508A - 푸로(3,2-c)피리딘 유도체, 그의 제법 및 그를 포함하는 의약 조성물 - Google Patents

푸로(3,2-c)피리딘 유도체, 그의 제법 및 그를 포함하는 의약 조성물 Download PDF

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Publication number
KR860002508A
KR860002508A KR1019850007089A KR850007089A KR860002508A KR 860002508 A KR860002508 A KR 860002508A KR 1019850007089 A KR1019850007089 A KR 1019850007089A KR 850007089 A KR850007089 A KR 850007089A KR 860002508 A KR860002508 A KR 860002508A
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KR
South Korea
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compound
group
hydrogen
phenyl
iii
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KR1019850007089A
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English (en)
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위크(외 2) 알렉산더
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에뚜레-레메뜨르
신떼라보
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Publication of KR860002508A publication Critical patent/KR860002508A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
  • Mushroom Cultivation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

내용 없음

Description

푸로[3,2-]피리딘 유도체, 그의 제법 및 그를 포함하는 의약 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. (ⅰ) 일반식(Ⅱ)
    의 4-옥소피페리딘을 피롤리딘과 반응시켜 화합물(Ⅲ)
    의 화합물을 제공하는 단계, 상기(Ⅱ), (Ⅲ)식에서 R4는 벤질, 벤조일 또는 아세틸기이다. (ⅱ) 상기 화합물(Ⅲ)을 일반식(Ⅳ)
    의 알파-브롬화케톤과 반응시켜 일반식(Ⅴ)
    의 화합물을 제공하는 단계, 상기(Ⅳ), (Ⅴ)식에서 R1은 페닐, 할로페닐, 메틸페닐, 에틸페닐, 메톡시페닐, 트리플루오로메틸페닐 또는 나프틸기를 나타내고 R2는 수소 또는 메틸 또는 페닐기를 나타내는데, R1이 페닐, 또는 4-플루오로페닐기이고 R2가 수소인 화합물은 제외한다. (ⅲ) 상기 화합물(Ⅴ)을 환형시켜 일반식(Ⅵ)
    의 푸로피리딘을 제공하는 단계, 그리고(ⅳ) R4가 아세틸 또는벤조일기일 때는 산 또는 강염기의 화합물(Ⅵ)을 아세틸 또는 벤조일기를 제거시키고 R3가 수소인 일반식(Ⅰ)의 화합물을 제공하거나, 또는 R4가 벤질기일 때는 선택적으로 화합물(Ⅵ)을 촉매 수소화반응시켜 R3가 수소인 일반식(Ⅰ)의 화합물을 제공하는 단계, 단계(Ⅳ)로부터 결과되는 일반식(Ⅰ)의 화합물은 선택적으로 공지의 방법 자체로써 산부가염으로 전환시키는, 위의 단계들로 이루어지는 것을 특징으로 하는 일반식(Ⅰ)
    의 화합물인 푸로[3,2-C피리딘 유도체 및 제약상 허용되는그의 산부가염을 제조하는 방법. 상기(Ⅰ)식에서 R1은 페닐, 할로페닐, 메틸페닐, 에틸페닐, 메톡시페닐, 트리플루오로메틸페닐 또는 나프틸기를 나타내며, R2는 수소 또는 메틸 또는 페닐기를 나타내고, R3는 수소 또는 벤질기를 나타내는데, R1이 페닐 또는 4-플루오로페닐기이고 R2가 수소, R3가 수소 또는 벤질기인 화합물은 제외한다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850007089A 1984-09-27 1985-09-26 푸로(3,2-c)피리딘 유도체, 그의 제법 및 그를 포함하는 의약 조성물 KR860002508A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR84/14842 1984-09-27
FR8414842A FR2570701B1 (fr) 1984-09-27 1984-09-27 Derives de furo(3,2-c)pyridines, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
KR860002508A true KR860002508A (ko) 1986-04-26

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ID=9308136

Family Applications (1)

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KR1019850007089A KR860002508A (ko) 1984-09-27 1985-09-26 푸로(3,2-c)피리딘 유도체, 그의 제법 및 그를 포함하는 의약 조성물

Country Status (19)

Country Link
US (1) US4661498A (ko)
EP (1) EP0178201B1 (ko)
JP (1) JPS61106577A (ko)
KR (1) KR860002508A (ko)
AT (1) ATE40554T1 (ko)
AU (1) AU573390B2 (ko)
CA (1) CA1291994C (ko)
DE (1) DE3568045D1 (ko)
DK (1) DK158953C (ko)
ES (1) ES8605522A1 (ko)
FI (1) FI82054C (ko)
FR (1) FR2570701B1 (ko)
GR (1) GR852356B (ko)
HU (1) HU192365B (ko)
IL (1) IL76535A0 (ko)
NO (1) NO162821C (ko)
NZ (1) NZ213620A (ko)
PT (1) PT81206B (ko)
ZA (1) ZA857457B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2566775B1 (fr) * 1984-06-27 1986-10-31 Synthelabo Derives de tetrahydro-4,5,6,7 furo ou 1h-pyrrolo(2,3-c)pyridine, leur preparation et leur application en therapeutique
FR2619112B1 (fr) * 1987-08-07 1989-11-17 Synthelabo Derives de (piperidinyl-4)methyl-2 benzo(b)furo(2,3-c) pyridines, leur preparation et leur application en therapeutique
FR2635977B1 (fr) * 1988-09-07 1992-05-15 Synthelabo Utilisation de derives de tetrahydro-4,5,6,7 furopyridines pour obtenir des medicaments destines au traitement de l'obesite
US5856194A (en) 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
US5795784A (en) 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
UA52681C2 (uk) * 1997-04-08 2003-01-15 Янссен Фармацевтика Н.В. Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі
UA70334C2 (en) 1998-10-06 2004-10-15 Janssen Pharmaceutica N V Jans BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS
SK285560B6 (sk) 1998-12-21 2007-03-01 Janssen Pharmaceutica N. V. Benzisoxazoly a fenoly ako alfa2-antagonisty, spôsob ich prípravy a farmaceutický prostriedok
AU776276B2 (en) * 1999-01-19 2004-09-02 Neurosearch A/S Fused heterocyclic compounds and their use in the treatment of neurodegenerative diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2215948B1 (ko) * 1973-02-01 1976-05-14 Centre Etd Ind Pharma
DD210278A5 (de) * 1982-03-05 1984-06-06 Boehringer Ingelheim Kg Verfahren zur herstellung neuer basisch substituierter 4-phenyl-4,5,6,7-tetrahydro-thieno-(2,3-c)pyridine

Also Published As

Publication number Publication date
FR2570701A1 (fr) 1986-03-28
ES8605522A1 (es) 1986-03-16
ES547315A0 (es) 1986-03-16
FI853719L (fi) 1986-03-28
FI82054C (fi) 1991-01-10
IL76535A0 (en) 1986-02-28
ZA857457B (en) 1986-05-28
HU192365B (en) 1987-05-28
AU573390B2 (en) 1988-06-09
JPS61106577A (ja) 1986-05-24
DK435285D0 (da) 1985-09-26
EP0178201B1 (fr) 1989-02-01
PT81206B (pt) 1988-01-22
FI853719A0 (fi) 1985-09-26
NZ213620A (en) 1988-01-08
NO853782L (no) 1986-04-01
EP0178201A1 (fr) 1986-04-16
US4661498A (en) 1987-04-28
NO162821B (no) 1989-11-13
GR852356B (ko) 1986-01-28
NO162821C (no) 1990-02-21
DK158953C (da) 1991-01-14
FI82054B (fi) 1990-09-28
DE3568045D1 (en) 1989-03-09
ATE40554T1 (de) 1989-02-15
DK158953B (da) 1990-08-06
CA1291994C (en) 1991-11-12
PT81206A (fr) 1985-10-01
DK435285A (da) 1986-03-28
AU4795285A (en) 1986-04-10
HUT38945A (en) 1986-07-28
FR2570701B1 (fr) 1987-05-22

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