KR890006621A - 항불안제 - Google Patents

항불안제 Download PDF

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Publication number
KR890006621A
KR890006621A KR1019880013911A KR880013911A KR890006621A KR 890006621 A KR890006621 A KR 890006621A KR 1019880013911 A KR1019880013911 A KR 1019880013911A KR 880013911 A KR880013911 A KR 880013911A KR 890006621 A KR890006621 A KR 890006621A
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KR
South Korea
Prior art keywords
anxiety
group
compound according
compound
pharmaceutically acceptable
Prior art date
Application number
KR1019880013911A
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English (en)
Other versions
KR900006722B1 (ko
Inventor
맥코완 웰치 쥬니어 윌라드
Original Assignee
윌리암 데이비스 헌
화이자 인코포레이티드
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Application filed by 윌리암 데이비스 헌, 화이자 인코포레이티드 filed Critical 윌리암 데이비스 헌
Publication of KR890006621A publication Critical patent/KR890006621A/ko
Application granted granted Critical
Publication of KR900006722B1 publication Critical patent/KR900006722B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Graft Or Block Polymers (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

항불안제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. 하기 구조식(I)로 표시되는 화합물 또는 그의 제약상 허용되는 산 부가염.
    상기 식중, R은 기
  2. 제1항에 있어서, R이 기(C)인 것을 특징으로 하는 화합물.
  3. 제1항에 있어서, R이 기(h)인 것을 특징으로 하는 화합물.
  4. 제1항에 있어서, R이 기(k)인 것을 특징으로 하는 화합뭍.
  5. 제1항에 있어서, R이 기(l)인 것을 특징으로 하는 화합물.
  6. 불안증을 앓고 있는 사람의 불안 치료용 의약품의 제조에 있어서 제1항에 의한 화합물의 용도.
  7. 제 I 항에 의한 화합물의 항불안 치료량 및 제약상 허용되는 담체로 되는 것을 특징으로 하는, 불안증을 앓고 있는 사람의 불안 치료용 제약 조성물.
  8. 하기 구조식(II)로 표시되는 화합물 또는 그의 제약상 허용되는 산 부가염.
    상기 식중, R¹은 기
  9. 제8항에 있어서, R1이 기(a)인 것을 특징으로 하는 화합물.
  10. 제8항에 있어서, R1이 기(e)인 것을 특징으로 하는 화합물.
  11. 제8항에 있어서, R1이 기(f)인 것을 특징으로 하는 화합물.
  12. 불안증을 앓고 있는 사람의 불안 치료용 의약품의 제조에 있어서 제8항에 의한 화합물의 용도.
  13. 제8항에 의한 화합물의 항불안 치료량 및 제약상 허용되는 담체로 되는 것을 특징으로 하는, 불안증을 앓고 있는 사람의 불안 치료용 제약 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880013911A 1987-10-26 1988-10-25 항불안제 KR900006722B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
USPCT87/02855 1987-10-26
USPCT/US87/02855 1987-10-26
PCT/US1987/002855 WO1989003831A1 (en) 1987-10-26 1987-10-26 Anti-anxiety agents

Publications (2)

Publication Number Publication Date
KR890006621A true KR890006621A (ko) 1989-06-14
KR900006722B1 KR900006722B1 (ko) 1990-09-20

Family

ID=22202642

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880013911A KR900006722B1 (ko) 1987-10-26 1988-10-25 항불안제

Country Status (28)

Country Link
US (1) US4994455A (ko)
EP (1) EP0314363B1 (ko)
JP (1) JPH0643406B2 (ko)
KR (1) KR900006722B1 (ko)
CN (1) CN1022246C (ko)
AT (1) ATE87919T1 (ko)
AU (1) AU598161B2 (ko)
CA (1) CA1314881C (ko)
CS (2) CS274441B2 (ko)
DD (2) DD298397A5 (ko)
DE (1) DE3880077T2 (ko)
DK (1) DK171788B1 (ko)
ES (1) ES2054823T3 (ko)
FI (1) FI94638C (ko)
HU (2) HU208690B (ko)
IE (1) IE63285B1 (ko)
IL (1) IL88085A (ko)
MX (1) MX173180B (ko)
MY (1) MY103435A (ko)
NO (2) NO901652D0 (ko)
NZ (1) NZ226691A (ko)
PH (1) PH25106A (ko)
PL (2) PL152117B1 (ko)
PT (1) PT88835B (ko)
RU (1) RU2029768C1 (ko)
WO (1) WO1989003831A1 (ko)
YU (1) YU46592B (ko)
ZA (1) ZA887925B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR242678A1 (es) * 1986-03-05 1993-04-30 Gonzalez Jorge Alberto Mejoras en instrumentos musicales de cuerda de arco.
US4797488A (en) * 1987-04-03 1989-01-10 American Home Products Corporation Psychotropic polycyclic imides
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
DE68918832T2 (de) * 1988-12-28 1995-02-09 Suntory Ltd Benzoxazepinderivate.
US5114936A (en) * 1990-08-23 1992-05-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use
UA77526C2 (en) * 2002-06-07 2006-12-15 Sanofi Aventis Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy
FR2862967B1 (fr) * 2003-12-01 2006-08-04 Sanofi Synthelabo Derives de (4-phenylpiperazin-1-yl)acylpiperidine, leur preparation et leur application en therapeutique
FR2862968B1 (fr) * 2003-12-01 2006-08-04 Sanofi Synthelabo Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique
US20110166124A1 (en) * 2008-07-23 2011-07-07 Mccormick Kevin D Tricyclic spirocycle derivatives and methods of use
US8617801B2 (en) * 2009-06-03 2013-12-31 Carestream Health, Inc. Film with blue dye

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US466691A (en) * 1892-01-05 Egg-crate
US2672460A (en) * 1952-06-24 1954-03-16 American Cyanamid Co Disubstituted piperazines and methods of preparing the same
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US4666911A (en) * 1981-07-14 1987-05-19 Taiho Pharmaceutical Company Limited Allophanoylpiperazine compound and analgesic composition containing same as active ingredient
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
JPS6175A (ja) * 1984-03-06 1986-01-06 ブリストル−マイア−ズ　コムパニ− 神経弛緩剤、１‐フルオロフェニルブチル‐４‐（５‐ハロ‐２‐ピリミジニル）ピペラジン誘導体
US4605655A (en) * 1984-03-06 1986-08-12 Bristol-Myers Company Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
US4562255A (en) * 1984-03-30 1985-12-31 American Home Products Corporation Substituted bi-alicyclic imides
US4668687A (en) * 1984-07-23 1987-05-26 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
AR242678A1 (es) * 1986-03-05 1993-04-30 Gonzalez Jorge Alberto Mejoras en instrumentos musicales de cuerda de arco.
US4797488A (en) * 1987-04-03 1989-01-10 American Home Products Corporation Psychotropic polycyclic imides

Also Published As

Publication number Publication date
DD283388A5 (de) 1990-10-10
NZ226691A (en) 1990-04-26
NO901652L (no) 1990-04-11
EP0314363A3 (en) 1990-07-11
ES2054823T3 (es) 1994-08-16
CS135189A2 (en) 1990-08-14
CS274446B2 (en) 1991-04-11
FI902070A0 (fi) 1990-04-25
CA1314881C (en) 1993-03-23
HU913849D0 (en) 1992-03-30
YU46592B (sh) 1993-11-16
DK171788B1 (da) 1997-05-26
NO901652D0 (no) 1990-04-11
FI94638C (fi) 1995-10-10
DK591488D0 (da) 1988-10-25
MX173180B (es) 1994-02-07
IE63285B1 (en) 1995-04-05
PH25106A (en) 1991-02-19
HU208690B (en) 1993-12-28
PT88835B (pt) 1993-01-29
CS708088A2 (en) 1990-08-14
ZA887925B (en) 1990-06-27
PL152117B1 (en) 1990-11-30
FI94638B (fi) 1995-06-30
NO901826D0 (no) 1990-04-25
DK591488A (da) 1989-04-27
MY103435A (en) 1993-06-30
IE883218L (en) 1989-04-26
IL88085A (en) 1993-02-21
AU598161B2 (en) 1990-06-14
US4994455A (en) 1991-02-19
DE3880077T2 (de) 1993-07-22
DD298397A5 (de) 1992-02-20
YU198988A (en) 1990-06-30
HUT59393A (en) 1992-05-28
EP0314363A2 (en) 1989-05-03
KR900006722B1 (ko) 1990-09-20
DE3880077D1 (de) 1993-05-13
HUT58724A (en) 1992-03-30
EP0314363B1 (en) 1993-04-07
PL153184B1 (en) 1991-03-29
RU2029768C1 (ru) 1995-02-27
AU2432788A (en) 1989-04-27
ATE87919T1 (de) 1993-04-15
PL279558A1 (en) 1990-01-08
CN1042148A (zh) 1990-05-16
MX13562A (es) 1993-04-01
WO1989003831A1 (en) 1989-05-05
CS274441B2 (en) 1991-04-11
JPH0643406B2 (ja) 1994-06-08
HU206109B (en) 1992-08-28
CN1022246C (zh) 1993-09-29
PL275476A1 (en) 1989-09-18
JPH01157979A (ja) 1989-06-21

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