CS274441B2 - Method of 1-acyl-3-/4-(2-pyrimidinyl)-1-piperazinyl/propanes production - Google Patents

Method of 1-acyl-3-/4-(2-pyrimidinyl)-1-piperazinyl/propanes production Download PDF

Info

Publication number
CS274441B2
CS274441B2 CS708088A CS708088A CS274441B2 CS 274441 B2 CS274441 B2 CS 274441B2 CS 708088 A CS708088 A CS 708088A CS 708088 A CS708088 A CS 708088A CS 274441 B2 CS274441 B2 CS 274441B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
pyrimidinyl
piperazinyl
compound
compounds
Prior art date
Application number
CS708088A
Other languages
Czech (cs)
English (en)
Other versions
CS708088A2 (en
Inventor
Willard Mckowan Welch Jr
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to CS135189A priority Critical patent/CS274446B2/cs
Publication of CS708088A2 publication Critical patent/CS708088A2/cs
Publication of CS274441B2 publication Critical patent/CS274441B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Graft Or Block Polymers (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CS708088A 1987-10-26 1988-10-26 Method of 1-acyl-3-/4-(2-pyrimidinyl)-1-piperazinyl/propanes production CS274441B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS135189A CS274446B2 (en) 1987-10-26 1989-03-02 Method of 1-acyl-3-/4-/2-pyrimidinyl/-1-piperazinyl/propanes production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1987/002855 WO1989003831A1 (en) 1987-10-26 1987-10-26 Anti-anxiety agents

Publications (2)

Publication Number Publication Date
CS708088A2 CS708088A2 (en) 1990-08-14
CS274441B2 true CS274441B2 (en) 1991-04-11

Family

ID=22202642

Family Applications (2)

Application Number Title Priority Date Filing Date
CS708088A CS274441B2 (en) 1987-10-26 1988-10-26 Method of 1-acyl-3-/4-(2-pyrimidinyl)-1-piperazinyl/propanes production
CS135189A CS274446B2 (en) 1987-10-26 1989-03-02 Method of 1-acyl-3-/4-/2-pyrimidinyl/-1-piperazinyl/propanes production

Family Applications After (1)

Application Number Title Priority Date Filing Date
CS135189A CS274446B2 (en) 1987-10-26 1989-03-02 Method of 1-acyl-3-/4-/2-pyrimidinyl/-1-piperazinyl/propanes production

Country Status (28)

Country Link
US (1) US4994455A (ko)
EP (1) EP0314363B1 (ko)
JP (1) JPH0643406B2 (ko)
KR (1) KR900006722B1 (ko)
CN (1) CN1022246C (ko)
AT (1) ATE87919T1 (ko)
AU (1) AU598161B2 (ko)
CA (1) CA1314881C (ko)
CS (2) CS274441B2 (ko)
DD (2) DD298397A5 (ko)
DE (1) DE3880077T2 (ko)
DK (1) DK171788B1 (ko)
ES (1) ES2054823T3 (ko)
FI (1) FI94638C (ko)
HU (2) HU208690B (ko)
IE (1) IE63285B1 (ko)
IL (1) IL88085A (ko)
MX (1) MX173180B (ko)
MY (1) MY103435A (ko)
NO (2) NO901652D0 (ko)
NZ (1) NZ226691A (ko)
PH (1) PH25106A (ko)
PL (2) PL152117B1 (ko)
PT (1) PT88835B (ko)
RU (1) RU2029768C1 (ko)
WO (1) WO1989003831A1 (ko)
YU (1) YU46592B (ko)
ZA (1) ZA887925B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR242678A1 (es) * 1986-03-05 1993-04-30 Gonzalez Jorge Alberto Mejoras en instrumentos musicales de cuerda de arco.
US4797488A (en) * 1987-04-03 1989-01-10 American Home Products Corporation Psychotropic polycyclic imides
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
DE68918832T2 (de) * 1988-12-28 1995-02-09 Suntory Ltd Benzoxazepinderivate.
US5114936A (en) * 1990-08-23 1992-05-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use
UA77526C2 (en) * 2002-06-07 2006-12-15 Sanofi Aventis Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy
FR2862967B1 (fr) * 2003-12-01 2006-08-04 Sanofi Synthelabo Derives de (4-phenylpiperazin-1-yl)acylpiperidine, leur preparation et leur application en therapeutique
FR2862968B1 (fr) * 2003-12-01 2006-08-04 Sanofi Synthelabo Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique
US20110166124A1 (en) * 2008-07-23 2011-07-07 Mccormick Kevin D Tricyclic spirocycle derivatives and methods of use
US8617801B2 (en) * 2009-06-03 2013-12-31 Carestream Health, Inc. Film with blue dye

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US466691A (en) * 1892-01-05 Egg-crate
US2672460A (en) * 1952-06-24 1954-03-16 American Cyanamid Co Disubstituted piperazines and methods of preparing the same
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US4666911A (en) * 1981-07-14 1987-05-19 Taiho Pharmaceutical Company Limited Allophanoylpiperazine compound and analgesic composition containing same as active ingredient
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
JPS6175A (ja) * 1984-03-06 1986-01-06 ブリストル−マイア−ズ　コムパニ− 神経弛緩剤、１‐フルオロフェニルブチル‐４‐（５‐ハロ‐２‐ピリミジニル）ピペラジン誘導体
US4605655A (en) * 1984-03-06 1986-08-12 Bristol-Myers Company Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
US4562255A (en) * 1984-03-30 1985-12-31 American Home Products Corporation Substituted bi-alicyclic imides
US4668687A (en) * 1984-07-23 1987-05-26 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
AR242678A1 (es) * 1986-03-05 1993-04-30 Gonzalez Jorge Alberto Mejoras en instrumentos musicales de cuerda de arco.
US4797488A (en) * 1987-04-03 1989-01-10 American Home Products Corporation Psychotropic polycyclic imides

Also Published As

Publication number Publication date
DD283388A5 (de) 1990-10-10
NZ226691A (en) 1990-04-26
NO901652L (no) 1990-04-11
EP0314363A3 (en) 1990-07-11
ES2054823T3 (es) 1994-08-16
CS135189A2 (en) 1990-08-14
CS274446B2 (en) 1991-04-11
FI902070A0 (fi) 1990-04-25
CA1314881C (en) 1993-03-23
HU913849D0 (en) 1992-03-30
YU46592B (sh) 1993-11-16
DK171788B1 (da) 1997-05-26
NO901652D0 (no) 1990-04-11
FI94638C (fi) 1995-10-10
DK591488D0 (da) 1988-10-25
MX173180B (es) 1994-02-07
IE63285B1 (en) 1995-04-05
PH25106A (en) 1991-02-19
HU208690B (en) 1993-12-28
KR890006621A (ko) 1989-06-14
PT88835B (pt) 1993-01-29
CS708088A2 (en) 1990-08-14
ZA887925B (en) 1990-06-27
PL152117B1 (en) 1990-11-30
FI94638B (fi) 1995-06-30
NO901826D0 (no) 1990-04-25
DK591488A (da) 1989-04-27
MY103435A (en) 1993-06-30
IE883218L (en) 1989-04-26
IL88085A (en) 1993-02-21
AU598161B2 (en) 1990-06-14
US4994455A (en) 1991-02-19
DE3880077T2 (de) 1993-07-22
DD298397A5 (de) 1992-02-20
YU198988A (en) 1990-06-30
HUT59393A (en) 1992-05-28
EP0314363A2 (en) 1989-05-03
KR900006722B1 (ko) 1990-09-20
DE3880077D1 (de) 1993-05-13
HUT58724A (en) 1992-03-30
EP0314363B1 (en) 1993-04-07
PL153184B1 (en) 1991-03-29
RU2029768C1 (ru) 1995-02-27
AU2432788A (en) 1989-04-27
ATE87919T1 (de) 1993-04-15
PL279558A1 (en) 1990-01-08
CN1042148A (zh) 1990-05-16
MX13562A (es) 1993-04-01
WO1989003831A1 (en) 1989-05-05
JPH0643406B2 (ja) 1994-06-08
HU206109B (en) 1992-08-28
CN1022246C (zh) 1993-09-29
PL275476A1 (en) 1989-09-18
JPH01157979A (ja) 1989-06-21

Similar Documents

Publication Publication Date Title
EP0054951B1 (en) Dibenz(b,f)(1,4)oxazepine derivatives, process for preparing the same, and pharmaceutical compositions comprising the same
JPS6049192B2 (ja) 新規置換ベンズアミド、その製造方法及びこれを有効成分とする向精神薬
SK284319B6 (sk) Substituované 3,5-difenyl-1,2,4-triazoly, ich použitie ako liečiv chelatujúcich kovy a spôsob ich prípravy
FR2518993A1 (fr) 2-(4-((4,4-dialkyl-2,6-piperidinedion-1-yl))-1-piperazinyl) pyrimidines, leur preparation et leur application pharmacologique
US6506911B2 (en) Pyrano [3,2-d]-1,3-dioxin-8 ones
US5872115A (en) 2-ureido-benzamide derivatives
CS274441B2 (en) Method of 1-acyl-3-/4-(2-pyrimidinyl)-1-piperazinyl/propanes production
AU569537B2 (en) Novel 1-piperazinecarboxamide derivatives
FR2601366A1 (fr) Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
US3532685A (en) N,n' - alkylene-n,n'-bis((alkoxy benzoyloxy)alkyl)alkylene diimines
CH639078A5 (fr) Amides derives d'acides carboxyliques-5 pyrimidiniques, leur preparation et medicaments les contenant.
CS225816B2 (en) The production process of the alkoxyphenylpyrrolidone with the cyclic substituents and with the nitrogen on the end of the aliphatic chain
CZ280084B6 (cs) Deriváty 2-(aminoalkyl)-5-(arylalkyl)-1,3-dioxanů způsob jejich přípravy a jejich terapeutické použití
US5023256A (en) Pharmacologically active aminoimidazopyridines
DK149133B (da) Analogifremgangsmaade til fremstilling af 2-(4-(diphenylmethylen)- l-piperidinyl)- eddikesyrer eller farmaceutisk acceptable salte heraf
US3860606A (en) Tetrahydro-imidazo-dibenzo-oxazepines, thiazepines and-diazepines
JP3053418B2 (ja) 新規の置換アルキルピペリジンとコレステロール合成阻害剤としてのその用途
US3988371A (en) Meta-[2-(benzylamino)-ethyl] benzoic acid amides
US3663610A (en) Amidine derivatives with spasmolytic,psychostimulant and anorexigenic properties
US5439940A (en) Benz[e]indene derivatives
JPS6145625B2 (ko)
US4656172A (en) 1-[5-(3,4,5-Trimethoxy phenyl)-2,4-pentadienoyl]-4-(substituted carbonylmethyl)-piperazines having vasodilating activity
US4320127A (en) Pyrido[3,2-e]-as-triazines
EP0141884B1 (en) Novel phenylpiperazine derivatives, process for preparing them and therapeutic compositions containing them
JPS6125035B2 (ko)

Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20071026