KR900018054A - 헤테로사이클릭구아니딘 5ht₃길항물질 - Google Patents

헤테로사이클릭구아니딘 5ht₃길항물질 Download PDF

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KR900018054A
KR900018054A KR1019900006421A KR900006421A KR900018054A KR 900018054 A KR900018054 A KR 900018054A KR 1019900006421 A KR1019900006421 A KR 1019900006421A KR 900006421 A KR900006421 A KR 900006421A KR 900018054 A KR900018054 A KR 900018054A
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South Korea
Prior art keywords
compound
guanidinomethyl
thiazole
methyl
indol
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KR1019900006421A
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KR920003927B1 (ko
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아담 나겔 아더
패트릭 리찌 제임스
제이 로젠 테리
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제이.트레버 럼
화이자 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

헤테로사이클릭아구아니딘 5HT3길항물질
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 일반식(Ⅰ)의 화합물 또는 그의 약학적으로 허용되는 산 부가염;
    상기식에서, Ar은 나프틸, 인돌-3-일, 2-메틸인돌-3-일, 1-메틸인돌-3-일, 1-벤질인돌-3-일, 페닐 또는 이치환된 페닐(치환기는 각각 메틸, 메톡시, 클로로, 플루오로 또는 브로모이다)이고;Het는 티아졸릴, 푸릴, 티에닐, 또는 이속사졸릴이고;R1은 수소 또는 메틸이고;R2및 R3는 각각 독립적으로 수소, 하이드록시에 틸, C1내지C6의 알킬, C3내지C6의 사이클로알킬 또는 아세틸이고, 함께 결합할 때는 C2내지C3의 알킬렌이다.
  2. 제1항에 있어서, Het가 티아졸릴이고, R1, R2, 및 R3가 각각 수소인 화합물.
  3. 제2항에 있어서, 2-(구아니디노메틸)-4-(1'-메틸인돌-3'-일)티아졸인 화합물.
  4. 제2항에 있어서, 2-(구아니디노메틸)-4-(0-메톡시페닐)티아졸인 화합물.
  5. 제2항에 있어서, 2-(구아니디노메틸)-4-(2'-메틸인돌-3'-일)티아졸인 화합물.
  6. 제2항에 있어서, 2-(구아니디노메틸)-4-(인돌-3'-일)티아졸인 화합물.
  7. 제2항에 있어서, 2-(구아니디노메틸)-4페닐티아졸인 화합물.
  8. 제2항에 있어서, 2-(인돌-3'-일)-4-(구아니디노메틸)티아졸인 화합물.
  9. 제2항에 있어서, 2-(구아니디노메틸)-4-(0-플루오로페닐)티아졸인 화합물.
    ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
KR1019900006421A 1989-05-09 1990-05-08 헤테로사이클릭구아니딘 5ht_3 길항물질 KR920003927B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US349189 1989-05-09
US07/349,189 US4963689A (en) 1989-05-19 1989-05-19 Heterocyclicguanidines as 5HT3 antagonists
US349,189 1994-12-05

Publications (2)

Publication Number Publication Date
KR900018054A true KR900018054A (ko) 1990-12-20
KR920003927B1 KR920003927B1 (ko) 1992-05-18

Family

ID=23371270

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900006421A KR920003927B1 (ko) 1989-05-09 1990-05-08 헤테로사이클릭구아니딘 5ht_3 길항물질

Country Status (19)

Country Link
US (1) US4963689A (ko)
EP (1) EP0397364B1 (ko)
JP (1) JPH0635454B2 (ko)
KR (1) KR920003927B1 (ko)
AT (1) ATE92062T1 (ko)
AU (1) AU615385B2 (ko)
CA (1) CA2016182C (ko)
DE (1) DE69002384T2 (ko)
DK (1) DK0397364T3 (ko)
ES (1) ES2058795T3 (ko)
FI (1) FI902291A0 (ko)
HU (1) HUT58063A (ko)
IE (1) IE62935B1 (ko)
IL (1) IL94254A (ko)
MY (1) MY105555A (ko)
NO (1) NO902029L (ko)
NZ (1) NZ233576A (ko)
PT (1) PT93979B (ko)
ZA (1) ZA903478B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5140034A (en) * 1989-03-14 1992-08-18 Merck Sharp & Dohme Ltd. Five-membered ring systems with bonded imidazolyl ring substituents
US5565479A (en) * 1992-09-14 1996-10-15 Yamanouchi Pharmaceutical Co., Ltd. Condensed thiazole derivative, production process thereof and pharmaceutical composition thereof
WO1995024399A1 (fr) * 1994-03-11 1995-09-14 Yamanouchi Pharmaceutical Co., Ltd. Agoniste de recepteur 5-ht3, nouveau derive de thiazole et intermediaire destine a son obtention
US5887415A (en) * 1995-05-11 1999-03-30 Bernard Matthews Plc Cooked, extruded meat product comprising additive
US5811425A (en) * 1997-03-04 1998-09-22 Abbott Laboratories Heterocyclic compounds as COX-2 inhibitors
DE102005027193A1 (de) * 2005-06-06 2006-12-07 Wilhelm Stahlecker Gmbh Zwillingseinheit mit zwei Streckwerken für eine Spinnmaschine
KR101779991B1 (ko) 2009-05-20 2017-09-19 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 병소성 전정 질환을 치료하기 위한 세로토닌 5-ｈｔ3 수용체 길항제의 용도
ES2432618T3 (es) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1031165A (en) * 1965-08-18 1966-05-25 Wellcome Found Guanidines, isoureas and isothioureas
GB1305549A (ko) * 1969-10-29 1973-02-07
DE2739723A1 (de) * 1977-09-03 1979-03-08 Merck Patent Gmbh 2-guanidinomethyl-indoline und verfahren zu ihrer herstellung
US4220654A (en) * 1979-06-04 1980-09-02 Merck & Co., Inc. Cyclic imidazole cyanoguanidines
US4563527A (en) * 1984-07-19 1986-01-07 Torii & Co., Ltd. Amidine compounds

Also Published As

Publication number Publication date
ES2058795T3 (es) 1994-11-01
MY105555A (en) 1994-10-31
PT93979B (pt) 1996-11-29
DE69002384T2 (de) 1993-11-18
NZ233576A (en) 1991-06-25
AU5476790A (en) 1990-11-15
EP0397364B1 (en) 1993-07-28
IE62935B1 (en) 1995-03-08
ATE92062T1 (de) 1993-08-15
HUT58063A (en) 1992-01-28
IE901664L (en) 1990-11-09
ZA903478B (en) 1991-12-24
FI902291A0 (fi) 1990-05-08
NO902029D0 (no) 1990-05-08
DE69002384D1 (de) 1993-09-02
DK0397364T3 (da) 1993-09-27
CA2016182A1 (en) 1990-11-09
JPH0635454B2 (ja) 1994-05-11
IL94254A (en) 1994-05-30
HU902976D0 (en) 1990-09-28
KR920003927B1 (ko) 1992-05-18
CA2016182C (en) 1996-03-12
JPH0311070A (ja) 1991-01-18
EP0397364A1 (en) 1990-11-14
AU615385B2 (en) 1991-09-26
US4963689A (en) 1990-10-16
PT93979A (pt) 1991-01-08
NO902029L (no) 1990-11-12

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