KR910002818A - 4,5,6,7-사치환된 벤즈옥사졸론 - Google Patents

4,5,6,7-사치환된 벤즈옥사졸론 Download PDF

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Publication number
KR910002818A
KR910002818A KR1019900010969A KR900010969A KR910002818A KR 910002818 A KR910002818 A KR 910002818A KR 1019900010969 A KR1019900010969 A KR 1019900010969A KR 900010969 A KR900010969 A KR 900010969A KR 910002818 A KR910002818 A KR 910002818A
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South Korea
Prior art keywords
compound
hydrogen
alkyl
halo
formula
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KR1019900010969A
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English (en)
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KR930002099B1 (ko
Inventor
나까네 마사미
마노 다까시
이토오 후미다까
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제이. 트레버 럼
화이자 인코포레이티드
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Publication of KR910002818A publication Critical patent/KR910002818A/ko
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Publication of KR930002099B1 publication Critical patent/KR930002099B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)

Abstract

내용 없음.

Description

4,5,6,7-사치환된 벤즈옥사졸론
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 일반식(I)의 화합물 또는 그의 약학적으로 허용가능한 산 부감염.
    상기식에서, R1은 수소 또는 C1내지 C3알킬이고, R2는 일반식-(CH2)m-Ar 또는 -(CH2)m-Het [이때 m은 1내지 6의 정수이고, Ar은 (C1내지 C3)알킬, (C1|내지 C3)알콕시, (C1내지 C3)알킬티오, 할로, (C1내지 C3)알킬아미노 또는 하이드록실로부터 선택된 하나 이상의 라디칼에 의해 임의로 치환된 페닐이고, Het는 푸릴, 티에닐, 피리딜, 피롤릴, 아미다졸릴, 피라닐, 옥사졸릴 또는 인다졸릴로부터 선택된다]의 그룹이고 Y1, Y2및 Y3는 각각 독립적으로 수소, (C1내지 C3|) 알킬, 할로 또는 (C1또는 C3)알콕시 또는 트리플루오로메틸이고, 단 Y1,Y2및 Y3중 최소한 2개는 수소가 아니다.
  2. 제1항에 있어서, m이 1인 화합물.
  3. 제1항에 있어서, R1이 H인 화합물.
  4. 제3항에 있어서, Y1이 수소인 화합물.
  5. 제4항에 있어서, Y1및 Y3가 각각 메틸 또는 플루오로인 화합물.
  6. 제1항에 있어서, 상기 화합물이 6-벤질아미노-4-플루오로-5-메틸-2-벤즈옥사졸론인 화합물.
  7. 제1항에 있어서, 상기 화합물이 6-벤질아미노-5-플루오로-4-메틸-2-벤즈옥사졸론인 화합물.
  8. 약학적으로 허용가능한 담체 또는 희석제중에 제1항의 화합물을 함유하는, 포유동물의 알러지성 또는 염증 질환 치료용 약학 조성물.
  9. 알러지성 또는 염증 질환으로 고통 받는 포유동물에게 알러지성 또는 염증 치료 효과량의 제1항의 화합물을 투여함을 포함하는, 상기 질환의 치료방법.
  10. 하기 일반식의 화합물.
    상기식에서, R은 아미노 또는 니트로이고, Y1, Y2및 Y3는 각각 독립적으로 수소, (C1내지 C3알킬 또는 할로이고, 단 Y1, Y2및 Y3|중 최소한 2개는 수소가 아니다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900010969A 1989-07-20 1990-07-19 4, 5, 6, 7-사치환된 벤즈옥사졸론 KR930002099B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1-188683 1989-07-20
JP188683 1989-07-20
JP1188683A JPH0678327B2 (ja) 1989-07-20 1989-07-20 ４，５，６，７，―四置換ベンゾオキサゾロン類

Publications (2)

Publication Number Publication Date
KR910002818A true KR910002818A (ko) 1991-02-26
KR930002099B1 KR930002099B1 (ko) 1993-03-26

Family

ID=16228012

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900010969A KR930002099B1 (ko) 1989-07-20 1990-07-19 4, 5, 6, 7-사치환된 벤즈옥사졸론

Country Status (18)

Country Link
US (1) US5071863A (ko)
EP (1) EP0409484B1 (ko)
JP (1) JPH0678327B2 (ko)
KR (1) KR930002099B1 (ko)
AT (1) ATE106877T1 (ko)
AU (1) AU616608B2 (ko)
CA (1) CA2021421A1 (ko)
DE (1) DE69009607T2 (ko)
DK (1) DK0409484T3 (ko)
ES (1) ES2055332T3 (ko)
FI (1) FI95378C (ko)
HU (1) HU206101B (ko)
IE (1) IE63203B1 (ko)
IL (1) IL95085A (ko)
NO (1) NO903230L (ko)
NZ (1) NZ234583A (ko)
PT (1) PT94750A (ko)
ZA (1) ZA905677B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2674524B1 (fr) * 1991-03-25 1993-05-21 Adir Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US7794761B2 (en) * 2000-04-13 2010-09-14 Seroctin Research & Technology, Inc. Methods for inducing anti-anxiety and calming effects in animals and humans
US20040192669A1 (en) 2000-04-13 2004-09-30 Rosenfeld Mark J. Novel compounds for use in weight loss and appetite suppression in humans
US7524877B2 (en) 2003-11-20 2009-04-28 Seroctin Research & Technology, Inc. Compounds for use in weight loss and appetite suppression in humans
JP4695012B2 (ja) * 2006-04-21 2011-06-08 セイコークロック株式会社 アラーム時計
PT2308877E (pt) 2008-08-05 2014-05-02 Daiichi Sankyo Co Ltd Derivados de imidazopiridin-2-ona

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3256293A (en) * 1964-02-05 1966-06-14 Monsanto Co 3-(phenylcarbamoyl) benzoxazolinones-2
US3657265A (en) * 1968-06-21 1972-04-18 Olin Corp Process for preparing benzoxazolones from aromatic nitro compounds
CA1048035A (en) * 1971-09-28 1979-02-06 Jozef Drabek Dithiophosphoric acid esters
US4227915A (en) * 1978-05-18 1980-10-14 Monsanto Company N-Substituted oxobenzothiazoline and oxobenzoxazoline derivatives and their use as plant growth regulants
JPS57123103A (en) * 1981-01-26 1982-07-31 Hokko Chem Ind Co Ltd Agricultural and horticultural fungicide
GB8325370D0 (en) * 1983-09-22 1983-10-26 Fujisawa Pharmaceutical Co Benzoxazoline and benzothiazoline derivatives
JPS6293283A (ja) * 1985-10-18 1987-04-28 Idemitsu Kosan Co Ltd ベンゾオキサゾロン誘導体，その製造方法およびそれを有効成分とする農園芸用殺菌剤
DK288287A (da) * 1986-06-09 1987-12-10 Pfizer Heterocycliske forbindelser samt farmaceutiske praeparater til behandling af allergiske eller inflammatoriske tilstande
US4835166A (en) * 1986-06-09 1989-05-30 Pfizer Inc. Antiallergy and antiinflammatory agents
IL93473A0 (en) * 1989-02-28 1990-11-29 Pfizer Antiinflammatory benzoxazolones

Also Published As

Publication number Publication date
DK0409484T3 (da) 1994-07-04
HU206101B (en) 1992-08-28
FI95378C (fi) 1996-01-25
JPH0352875A (ja) 1991-03-07
IL95085A0 (en) 1991-06-10
DE69009607T2 (de) 1994-09-22
NO903230D0 (no) 1990-07-19
CA2021421A1 (en) 1991-01-21
KR930002099B1 (ko) 1993-03-26
IL95085A (en) 1994-10-21
PT94750A (pt) 1991-03-20
DE69009607D1 (de) 1994-07-14
US5071863A (en) 1991-12-10
ATE106877T1 (de) 1994-06-15
EP0409484A3 (en) 1991-05-15
FI95378B (fi) 1995-10-13
EP0409484B1 (en) 1994-06-08
JPH0678327B2 (ja) 1994-10-05
NZ234583A (en) 1991-12-23
NO903230L (no) 1991-01-21
HU904565D0 (en) 1990-12-28
IE902630A1 (en) 1991-02-27
ES2055332T3 (es) 1994-08-16
ZA905677B (en) 1992-02-26
FI903655A0 (fi) 1990-07-19
EP0409484A2 (en) 1991-01-23
AU616608B2 (en) 1991-10-31
IE63203B1 (en) 1995-04-05
HUT57745A (en) 1991-12-30
AU5919390A (en) 1991-01-24

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