PT2308877E - Derivados de imidazopiridin-2-ona - Google Patents

Derivados de imidazopiridin-2-ona Download PDF

Info

Publication number
PT2308877E
PT2308877E PT98049737T PT09804973T PT2308877E PT 2308877 E PT2308877 E PT 2308877E PT 98049737 T PT98049737 T PT 98049737T PT 09804973 T PT09804973 T PT 09804973T PT 2308877 E PT2308877 E PT 2308877E
Authority
PT
Portugal
Prior art keywords
imidazopyridin
derivatives
Prior art date
Application number
PT98049737T
Other languages
English (en)
Inventor
Noriyasu Haginoya
Masami Ohtsuka
Masanori Ichikawa
Hironori Matsunaga
Hironao Saito
Yoshihiro Shibata
Tomoyuki Tsunemi
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of PT2308877E publication Critical patent/PT2308877E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT98049737T 2008-08-05 2009-08-04 Derivados de imidazopiridin-2-ona PT2308877E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008201670 2008-08-05
JP2009078540 2009-03-27

Publications (1)

Publication Number Publication Date
PT2308877E true PT2308877E (pt) 2014-05-02

Family

ID=41663708

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98049737T PT2308877E (pt) 2008-08-05 2009-08-04 Derivados de imidazopiridin-2-ona

Country Status (22)

Country Link
US (2) US8436012B2 (pt)
EP (1) EP2308877B1 (pt)
JP (1) JP5630867B2 (pt)
KR (1) KR20110039307A (pt)
CN (1) CN102171210B (pt)
AU (1) AU2009278442B2 (pt)
BR (1) BRPI0917540A2 (pt)
CA (1) CA2732950C (pt)
CO (1) CO6300866A2 (pt)
DK (1) DK2308877T3 (pt)
ES (1) ES2459047T3 (pt)
HK (1) HK1155444A1 (pt)
IL (1) IL211042A (pt)
MX (1) MX2011001019A (pt)
MY (1) MY153606A (pt)
NZ (1) NZ590688A (pt)
PL (1) PL2308877T3 (pt)
PT (1) PT2308877E (pt)
RU (1) RU2478636C2 (pt)
TW (1) TWI436998B (pt)
WO (1) WO2010016490A1 (pt)
ZA (1) ZA201100799B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010068483A2 (en) * 2008-11-25 2010-06-17 University Of Rochester Mlk inhibitors and methods of use
WO2011021678A1 (ja) * 2009-08-21 2011-02-24 武田薬品工業株式会社 縮合複素環化合物
US8846909B2 (en) 2010-05-24 2014-09-30 University Of Rochester Bicyclic heteroaryl kinase inhibitors and methods of use
US20130165426A1 (en) * 2010-07-06 2013-06-27 Université de Montréal Imidazopyridine, imidazopyrimidine and imidazopyrazine derivatives as melanocortin-4 receptor modulators
US9018395B2 (en) 2011-01-27 2015-04-28 Université de Montréal Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators
KR101274986B1 (ko) * 2011-07-27 2013-06-17 한국과학기술원 이미다조피리딘 유도체, 이를 포함하는 ＰＩ3Ｋ 및/또는 ｍＴＯＲ 저해제용 약학 조성물 및 ＰＩ3Ｋ 및/또는 ｍＴＯＲ과 연관된 질환 치료용 약학 조성물
CN102702196B (zh) * 2012-06-13 2015-01-14 南京药石药物研发有限公司 3-甲基-7-氮杂吲哚的合成方法
WO2014060395A1 (en) * 2012-10-16 2014-04-24 F. Hoffmann-La Roche Ag Serine/threonine kinase inhibitors
WO2014085795A1 (en) 2012-11-30 2014-06-05 University Of Rochester Mixed lineage kinase inhibitors for hiv/aids therapies
WO2014134240A1 (en) * 2013-02-28 2014-09-04 Signal Pharmaceuticals, Llc Treatment of cancer with tor kinase inhibitors
WO2015013579A1 (en) 2013-07-26 2015-01-29 Update Pharma Inc. Compositions to improve the therapeutic benefit of bisantrene
US9771351B2 (en) 2013-07-29 2017-09-26 Kyowa Hakko Kirin Co., Ltd. Wnt signaling inhibitor
US10155727B2 (en) 2014-08-15 2018-12-18 Janssen Pharmaceuticals, Inc. Pyrazoles
WO2016025917A1 (en) 2014-08-15 2016-02-18 Janssen Pharmaceuticals, Inc. Triazoles as nr2b receptor inhibitors
KR20180026760A (ko) 2015-07-09 2018-03-13 얀센 파마슈티카 엔.브이. 치환된 4-아자인돌 및 glun2b 수용체 조절제로서의 이의 용도
US10071988B2 (en) 2016-02-10 2018-09-11 Janssen Pharmaceutica Nv Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators
US10577382B2 (en) 2016-04-28 2020-03-03 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
CN106187899B (zh) * 2016-06-28 2019-07-16 绍兴文理学院 一种氟代氮杂芳烃的合成方法
TW201819376A (zh) * 2016-10-06 2018-06-01 比利時商健生藥品公司 經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途
CN107118084B (zh) * 2017-06-27 2021-06-08 江苏合泰新材料科技有限公司 一种两步法合成1,3-双取代基-2-丙醇的方法
CN107550905B (zh) * 2017-09-11 2020-07-17 浙江永宁药业股份有限公司 多取代吡咯并吡啶类化合物的药物用途及其制备方法
WO2019193516A2 (en) 2018-04-04 2019-10-10 Janssen Pharmaceutica Nv Substituted pyridine and pyrimidines and their use as glun2b receptor modulators
TWI837231B (zh) 2018-11-29 2024-04-01 日商第一三共股份有限公司 含有ｅｚｈ１／２雙重抑制劑之醫藥組合及其用途
JP7212781B2 (ja) 2018-12-19 2023-01-25 ディスアーム セラピューティクス， インコーポレイテッド 神経保護剤と組み合わせたｓａｒｍ１の阻害剤
AU2020293584A1 (en) 2019-06-14 2022-01-20 Janssen Pharmaceutica Nv Pyridine carbamates and their use as GluN2B receptor modulators
EP3982958A1 (en) 2019-06-14 2022-04-20 Janssen Pharmaceutica NV Substituted heteroaromatic pyrazolo-pyridines and their use as glun2b receptor modulators
JOP20210328A1 (ar) 2019-06-14 2023-01-30 Janssen Pharmaceutica Nv مركبات أميدات بيريدين-بيرازولو المستبدلة واستخدامها باعتبارها معدِّلات لمستقبل الغلوتومات "glun2b"
US20220324860A1 (en) 2019-06-14 2022-10-13 Janssen Pharmaceutica Nv SUBSTITUTED PYRAZOLO[4,3-b]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS
JP2022536773A (ja) 2019-06-14 2022-08-18 ヤンセン ファーマシューティカ エヌ．ベー． 置換ピラゾロピラジン及びｇｌｕｎ２ｂ受容体調節因子としてのそれらの使用
WO2020249796A1 (en) 2019-06-14 2020-12-17 Janssen Pharmaceutica Nv Pyrazine carbamates and their use as glun2b receptor modulators
WO2022166920A1 (zh) * 2021-02-08 2022-08-11 杭州中美华东制药有限公司 一种吡咯并哒嗪类化合物及其制备方法和用途
EP4074712A1 (en) 2021-04-13 2022-10-19 Siegfried AG Process for the synthesis of 1,3-dihydro-imidazo[4,5-b]pyridin-2-one and/or derivatives thereof
WO2024081889A1 (en) 2022-10-14 2024-04-18 Genesis Therapeutics, Inc. 4h-pyrido[1,2-a]pyrimidin-4-one derivatives for treating cancer

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294837A (en) 1980-03-28 1981-10-13 Sterling Drug Inc. 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use
US4532337A (en) 1984-02-28 1985-07-30 Basf Aktiengesellschaft Preparation of 3-formyl-5,6-dihydro-2H-pyran
JPH0678327B2 (ja) 1989-07-20 1994-10-05 ファイザー製薬株式会社 ４，５，６，７，―四置換ベンゾオキサゾロン類
IN188411B (pt) 1997-03-27 2002-09-21 Yuhan Corp
WO1999057103A1 (fr) * 1998-04-30 1999-11-11 Nippon Chemiphar Co., Ltd. Derive d'imidazole condense et agent therapeutique permettant de traiter une maladie du foie
ATE309250T1 (de) 1999-09-10 2005-11-15 Novo Nordisk As Modulatoren der protein tyrosin phosphatase (ptpases)
US7511144B2 (en) 2001-09-07 2009-03-31 Kaken Pharmaceutical Co., Ltd. Reverse hydroxamic acid derivatives
WO2003028724A1 (en) 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
JP2003221386A (ja) 2001-11-26 2003-08-05 Takeda Chem Ind Ltd 二環性誘導体、その製造法およびその用途
DE10228103A1 (de) 2002-06-24 2004-01-15 Bayer Cropscience Ag Fungizide Wirkstoffkombinationen
US20040166137A1 (en) 2002-11-08 2004-08-26 Lackey John William Hetero-substituted benzimidazole compounds and antiviral uses thereof
JP4279784B2 (ja) * 2002-12-04 2009-06-17 エーザイ・アール・アンド・ディー・マネジメント株式会社 １，３−ジヒドロ−イミダゾール縮合環化合物
EP1628975A2 (en) 2003-05-16 2006-03-01 Eisai Co., Ltd. Jnk inhibitors
US7563748B2 (en) 2003-06-23 2009-07-21 Cognis Ip Management Gmbh Alcohol alkoxylate carriers for pesticide active ingredients
KR20060119871A (ko) * 2003-08-21 2006-11-24 오에스아이 파마슈티컬스, 인코포레이티드 Ｎ３―치환된 이미다조피리딘 ｃ―ｋｉｔ 억제제
ES2241496B1 (es) 2004-04-15 2006-12-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridina.
WO2006000020A1 (en) 2004-06-29 2006-01-05 European Nickel Plc Improved leaching of base metals
NZ553267A (en) 2004-07-27 2010-09-30 Sgx Pharmaceuticals Inc Pyrrolo-pyridine kinase modulators
GB0420719D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
US7745470B2 (en) 2005-03-10 2010-06-29 Bristol-Myers Squibb Company Isophthalates as beta-secretase inhibitors
US7994325B2 (en) * 2005-03-14 2011-08-09 Merck Sharp & Dohme Corp. CGRP receptor antagonists
CA2603830A1 (en) 2005-05-24 2006-11-30 Pharmacia & Upjohn Co Llc PYRIDINE [2,3-B] PYRAZINONES
CN101227857B (zh) 2005-06-29 2011-10-19 电脑医师有限公司 具有导电桥的传感器组件
GB0513840D0 (en) 2005-07-07 2005-08-10 Medivir Ab Cysteine protease inhibitors
TWI411607B (zh) 2005-11-14 2013-10-11 Vitae Pharmaceuticals Inc 天門冬胺酸蛋白酶抑制劑
RU2008143179A (ru) 2006-03-31 2010-05-10 Новартис АГ (CH) Органические соединения
WO2007135398A1 (en) 2006-05-22 2007-11-29 Astrazeneca Ab Indole derivatives
TW200801513A (en) 2006-06-29 2008-01-01 Fermiscan Australia Pty Ltd Improved process
JP2009544625A (ja) 2006-07-20 2009-12-17 メーメット・カーラマン Ｒｈｏキナーゼのベンゾチオフェン阻害剤
SI2057156T1 (sl) 2006-08-23 2017-06-30 Kudos Pharmaceuticals Limited Derivati 2-metilmorfolin pirido-, pirazo- in pirimido-pirimidina kot inhibitorji mTOR
WO2008029825A1 (fr) 2006-09-05 2008-03-13 Kyowa Hakko Kirin Co., Ltd. Dérivé d'imidazole
ZA200902382B (en) 2006-10-19 2010-08-25 Signal Pharm Llc Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors
ES2383370T3 (es) * 2006-10-19 2012-06-20 Signal Pharmaceuticals Llc Compuestos de heteroarilo, sus composiciones y uso de los mismos como inhibidores de proteína quinasa
TW200901998A (en) 2007-03-06 2009-01-16 Astrazeneca Ab Novel 2-heteroaryl substituted benzothiophenes and benzofuranes
JP4792126B2 (ja) 2007-08-01 2011-10-12 ファイザー・インク ピラゾール化合物およびＲａｆ阻害剤としてのその使用
EP2311842A3 (en) 2008-06-24 2011-07-13 Takeda Pharmaceutical Company Limited PI3K/M TOR inhibitors
WO2010000020A1 (en) 2008-06-30 2010-01-07 Cathrx Ltd A catheter
BRPI0917394A2 (pt) 2008-08-18 2019-09-24 Univ Yale moduladores de mif
WO2010068483A2 (en) 2008-11-25 2010-06-17 University Of Rochester Mlk inhibitors and methods of use
WO2011000020A1 (en) 2009-06-12 2011-01-06 Sbc Research Pty Ltd Enhanced method of detection
WO2011096490A1 (ja) * 2010-02-04 2011-08-11 第一三共株式会社 イミダゾピリジン－２－オン誘導体

Also Published As

Publication number Publication date
US20130338156A1 (en) 2013-12-19
DK2308877T3 (da) 2014-04-22
ES2459047T3 (es) 2014-05-07
CA2732950A1 (en) 2010-02-11
CN102171210A (zh) 2011-08-31
ZA201100799B (en) 2011-10-26
HK1155444A1 (en) 2012-05-18
MY153606A (en) 2015-02-27
PL2308877T3 (pl) 2014-07-31
IL211042A (en) 2014-12-31
AU2009278442B2 (en) 2013-09-26
CA2732950C (en) 2013-10-01
CN102171210B (zh) 2014-04-23
NZ590688A (en) 2012-09-28
WO2010016490A1 (ja) 2010-02-11
TW201011021A (en) 2010-03-16
EP2308877A1 (en) 2011-04-13
RU2478636C2 (ru) 2013-04-10
AU2009278442A1 (en) 2010-02-11
RU2011108453A (ru) 2012-09-10
US8436012B2 (en) 2013-05-07
KR20110039307A (ko) 2011-04-15
MX2011001019A (es) 2011-03-25
EP2308877A4 (en) 2012-03-14
IL211042A0 (en) 2011-04-28
JP5630867B2 (ja) 2014-11-26
EP2308877B1 (en) 2014-01-22
US8785438B2 (en) 2014-07-22
US20110082138A1 (en) 2011-04-07
JPWO2010016490A1 (ja) 2012-01-26
BRPI0917540A2 (pt) 2015-11-17
TWI436998B (zh) 2014-05-11
CO6300866A2 (es) 2011-07-21

Similar Documents

Publication Publication Date Title
HK1256310A1 (zh) N-磺酰基吡咯衍生物
IL210548A0 (en) Spiroaminodihydrothiazine derivatives
EP2376494A4 (en) DIHYDROPYRIMIDOPIRYMIDINE DERIVATIVES
ZA201100799B (en) Imidazopyridin-2-one derivatives
SG10201506608RA (en) 3-deazaneplanocin derivatives
ZA201100876B (en) Pyrrolopyridinylpyrimidin-2-ylamine derivatives
EP2291078A4 (en) OXAZOLBENZIMIDAZOLDERIVATE
EP2376493A4 (en) DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVE
ZA201102449B (en) Morpholinopurine derivatives
EP2380877A4 (en) PYRIDINE-3-CARBONSÄUREAMIDDERIVAT
EP2279532A4 (en) OXAZOLBENZIMIDAZOLDERIVATE
IL210869A0 (en) Imidazothiadiazoles derivatives
EP2269993A4 (en) 2-aminoquinazoline DERIVATIVE
IL208336A0 (en) Pyrisazinone derivatives
EP2241567A4 (en) Bicycloamine DERIVATIVE
ZA201100948B (en) Acylaminobenzamide derivatives
IL211290A0 (en) New 2-amidothiadiazole derivatives
IL210164A0 (en) Thiazolylpiperidine derivatives
ZA201005382B (en) Substituted heteroarylamide diazepinopyrimidone derivatives
ZA201005381B (en) Substituted heteroarylamide oxazepinopyrimidone derivatives
ZA201105050B (en) Quinazolinamide derivatives
ZA201008052B (en) 2-phenyl-4-cyclopropyl-pyrimidine derivatives
EP2292613A4 (en) DIHYDROINDOLINONDERIVATE
EP2258697A4 (en) HYDROXYCHINOXALINCARBOXAMIDDERIVAT
EP2248811A4 (en) 2-OXOCHROMENE DERIVATIVE