ATE270103T1 - Aminophenoxyessigsäure derivate als neuroschützende mittel - Google Patents
Aminophenoxyessigsäure derivate als neuroschützende mittelInfo
- Publication number
- ATE270103T1 ATE270103T1 AT99947887T AT99947887T ATE270103T1 AT E270103 T1 ATE270103 T1 AT E270103T1 AT 99947887 T AT99947887 T AT 99947887T AT 99947887 T AT99947887 T AT 99947887T AT E270103 T1 ATE270103 T1 AT E270103T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- acid derivatives
- aminophenoxyacetic acid
- neuroprotective agents
- aminophenoxyacetic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29488698 | 1998-10-16 | ||
| PCT/JP1999/005658 WO2000023076A1 (en) | 1998-10-16 | 1999-10-14 | Aminophenoxyacetic acid derivatives as neuroprotectants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE270103T1 true ATE270103T1 (de) | 2004-07-15 |
Family
ID=17813532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99947887T ATE270103T1 (de) | 1998-10-16 | 1999-10-14 | Aminophenoxyessigsäure derivate als neuroschützende mittel |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US6559146B1 (de) |
| EP (1) | EP1045693B1 (de) |
| JP (1) | JP2002527477A (de) |
| KR (1) | KR100676109B1 (de) |
| CN (1) | CN1198613C (de) |
| AT (1) | ATE270103T1 (de) |
| AU (1) | AU762345B2 (de) |
| CA (1) | CA2315050C (de) |
| DE (1) | DE69918404T2 (de) |
| ES (1) | ES2221440T3 (de) |
| HU (1) | HUP0100819A3 (de) |
| WO (1) | WO2000023076A1 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6559146B1 (en) * | 1998-10-16 | 2003-05-06 | Suntory Limited | Aminophenoxyacetic acid derivatives as neuroprotectants |
| SE9902987D0 (sv) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
| KR100879647B1 (ko) | 2000-03-06 | 2009-01-20 | 아카디아 파마슈티칼스 인코포레이티드 | 세로토닌 관련 질병의 치료에 사용되는 아자시클릭 화합물 |
| DE60130628T2 (de) * | 2000-04-13 | 2008-07-10 | Asubio Pharma Co., Ltd. | Aminophenoxyacetamid derivate und diese enthaltende pharmazeutische zusammensetzungen |
| EP1313713B1 (de) * | 2000-08-08 | 2008-06-11 | Ortho-McNeil Pharmaceutical, Inc. | 4-pyrimidinamine derivate, pharmazeutische zusammenstellungen und verwandte methoden |
| US6376514B1 (en) * | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| US6693099B2 (en) * | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| GB0104050D0 (en) | 2001-02-19 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| GB0107228D0 (en) | 2001-03-22 | 2001-05-16 | Astrazeneca Ab | Chemical compounds |
| US20030186963A1 (en) * | 2001-09-14 | 2003-10-02 | Dorwald Florencio Zaragoza | Substituted piperidines |
| SE0103818D0 (sv) | 2001-11-15 | 2001-11-15 | Astrazeneca Ab | Chemical compounds |
| CN100372848C (zh) | 2001-12-28 | 2008-03-05 | 阿卡蒂亚药品公司 | 作为单胺受体调节剂的螺氮杂环化合物 |
| MXPA04012893A (es) | 2002-06-24 | 2005-03-31 | Acadia Pharm Inc | Derivados de piperidina n-substituidos como agentes receptores de serotonina. |
| US7538222B2 (en) | 2002-06-24 | 2009-05-26 | Acadia Pharmaceuticals, Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
| US7253186B2 (en) | 2002-06-24 | 2007-08-07 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
| CA2512639C (en) | 2003-01-16 | 2012-10-30 | Acadia Pharmaceuticals Inc. | Selective serotonin 2a/2c receptor inverse agonists as therapeutics for neurodegenerative diseases |
| US7820695B2 (en) | 2004-05-21 | 2010-10-26 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
| US20050261278A1 (en) | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
| EP1758580A4 (de) | 2004-06-24 | 2008-01-16 | Incyte Corp | N-substituierte piperidine und ihre verwendung als arzneimittel |
| EP1768954A4 (de) * | 2004-06-24 | 2008-05-28 | Incyte Corp | 2-methylpropanamide und deren verwendung als pharmazeutika |
| US7790899B2 (en) | 2004-09-27 | 2010-09-07 | Acadia Pharmaceuticals, Inc. | Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms |
| US7732615B2 (en) | 2004-09-27 | 2010-06-08 | Acadia Pharmaceuticals Inc. | N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms |
| TW200630337A (en) * | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
| EP1952112A4 (de) | 2005-10-05 | 2010-01-13 | Lg Electronics Inc | Verfahren und vorrichtung zur signalverarbeitung und codierungs- und decodierungsverfahren und vorrichtung dafür |
| KR100857112B1 (ko) | 2005-10-05 | 2008-09-05 | 엘지전자 주식회사 | 신호 처리 방법 및 이의 장치, 그리고 인코딩 및 디코딩방법 및 이의 장치 |
| US8068569B2 (en) | 2005-10-05 | 2011-11-29 | Lg Electronics, Inc. | Method and apparatus for signal processing and encoding and decoding |
| WO2007110449A1 (en) * | 2006-03-29 | 2007-10-04 | Euro-Celtique S.A. | Benzenesulfonamide compounds and their use |
| TW200815353A (en) * | 2006-04-13 | 2008-04-01 | Euro Celtique Sa | Benzenesulfonamide compounds and their use |
| US8937181B2 (en) * | 2006-04-13 | 2015-01-20 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| WO2008116024A2 (en) | 2007-03-19 | 2008-09-25 | Acadia Pharmaceuticals Inc. | Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics |
| US8399486B2 (en) * | 2007-04-09 | 2013-03-19 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use thereof |
| CN103396399B (zh) * | 2007-04-27 | 2015-04-29 | 第一三共株式会社 | 含氮芳香族六元环衍生物及含有它们的药物 |
| US8765736B2 (en) * | 2007-09-28 | 2014-07-01 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| HUE055763T2 (hu) | 2015-07-20 | 2021-12-28 | Acadia Pharm Inc | Eljárás N-(4-fluorbenzil)-N-(1-metilpiperidin-4-il)-N'-(4-(2-metil-propil-oxi)fenil-metil)karbamid vagy ennek tartarát-sója és C polimorf formája elõállítására |
| WO2017165635A1 (en) | 2016-03-25 | 2017-09-28 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome p450 modulators |
| US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
| CN109563071B (zh) * | 2016-06-08 | 2021-08-03 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为atf4途径抑制剂的化学化合物 |
| US11464768B2 (en) | 2016-12-20 | 2022-10-11 | Acadia Pharmaceuticals Inc. | Pimavanserin alone or in combination for use in the treatment of Alzheimer's disease psychosis |
| US11135211B2 (en) | 2017-04-28 | 2021-10-05 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
| SG11202000532SA (en) | 2017-08-09 | 2020-02-27 | Denali Therapeutics Inc | Compounds, compositions and methods |
| EP3675827A1 (de) | 2017-08-30 | 2020-07-08 | Acadia Pharmaceuticals Inc. | Formulierungen von pimavanserin |
| US20210130308A1 (en) * | 2018-03-23 | 2021-05-06 | Denali Therapeutics Inc. | Modulators of eukaryotic initiation factor 2 |
| AU2020223228A1 (en) | 2019-02-13 | 2021-08-26 | Denali Therapeutics Inc. | Compounds, compositions and methods |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5214147A (en) * | 1987-08-12 | 1993-05-25 | Elf Atochem North America, Inc. | Process for preparing reactive hindered amine light stabilizers |
| CA1306995C (en) * | 1987-11-27 | 1992-09-01 | Kohshi Ueno | Cyclic amine and pharmacological composition |
| DE4032766A1 (de) * | 1990-10-16 | 1992-04-30 | Basf Ag | Phenylpiperidinoylamine und diese enthaltende arzneimittel |
| IL105716A0 (en) * | 1992-06-08 | 1993-09-22 | Richter Gedeon Vegyeszet | Aminopropanol derivatives,their preparation and pharmaceutical compositions containing them |
| KR19990037220A (ko) * | 1997-10-31 | 1999-05-25 | 타이도 나오카타 | 아릴아세트산 아미드 유도체 또는 그 염 및 이를 함유하는 의약 |
| US6559146B1 (en) | 1998-10-16 | 2003-05-06 | Suntory Limited | Aminophenoxyacetic acid derivatives as neuroprotectants |
-
1999
- 1999-10-14 US US09/581,756 patent/US6559146B1/en not_active Expired - Fee Related
- 1999-10-14 KR KR1020007006551A patent/KR100676109B1/ko not_active IP Right Cessation
- 1999-10-14 AU AU61226/99A patent/AU762345B2/en not_active Ceased
- 1999-10-14 ES ES99947887T patent/ES2221440T3/es not_active Expired - Lifetime
- 1999-10-14 EP EP99947887A patent/EP1045693B1/de not_active Expired - Lifetime
- 1999-10-14 AT AT99947887T patent/ATE270103T1/de not_active IP Right Cessation
- 1999-10-14 WO PCT/JP1999/005658 patent/WO2000023076A1/en not_active Application Discontinuation
- 1999-10-14 JP JP2000576850A patent/JP2002527477A/ja not_active Abandoned
- 1999-10-14 DE DE69918404T patent/DE69918404T2/de not_active Expired - Lifetime
- 1999-10-14 CA CA002315050A patent/CA2315050C/en not_active Expired - Fee Related
- 1999-10-14 CN CNB998018171A patent/CN1198613C/zh not_active Expired - Fee Related
- 1999-10-14 HU HU0100819A patent/HUP0100819A3/hu unknown
-
2003
- 2003-03-24 US US10/394,221 patent/US6998401B2/en not_active Expired - Fee Related
-
2005
- 2005-07-06 US US11/174,575 patent/US7488738B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69918404D1 (de) | 2004-08-05 |
| US20040063748A1 (en) | 2004-04-01 |
| WO2000023076A1 (en) | 2000-04-27 |
| US7488738B2 (en) | 2009-02-10 |
| ES2221440T3 (es) | 2004-12-16 |
| HUP0100819A3 (en) | 2002-12-28 |
| CN1287487A (zh) | 2001-03-14 |
| AU762345B2 (en) | 2003-06-26 |
| EP1045693A1 (de) | 2000-10-25 |
| US20050245574A1 (en) | 2005-11-03 |
| CA2315050C (en) | 2009-02-03 |
| KR100676109B1 (ko) | 2007-02-01 |
| EP1045693B1 (de) | 2004-06-30 |
| JP2002527477A (ja) | 2002-08-27 |
| KR20010033169A (ko) | 2001-04-25 |
| US6998401B2 (en) | 2006-02-14 |
| DE69918404T2 (de) | 2005-08-04 |
| US6559146B1 (en) | 2003-05-06 |
| CA2315050A1 (en) | 2000-04-27 |
| CN1198613C (zh) | 2005-04-27 |
| AU6122699A (en) | 2000-05-08 |
| HUP0100819A2 (hu) | 2001-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |