KR910016694A - 티오카르바모일아세토니트릴 화합물 - Google Patents

티오카르바모일아세토니트릴 화합물 Download PDF

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KR910016694A
KR910016694A KR1019910003553A KR910003553A KR910016694A KR 910016694 A KR910016694 A KR 910016694A KR 1019910003553 A KR1019910003553 A KR 1019910003553A KR 910003553 A KR910003553 A KR 910003553A KR 910016694 A KR910016694 A KR 910016694A
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alkyl
compound
halogen
substituted
heterocyclic group
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히로미 오꾸시마
아끼히로 토베
마끼오 고바야시
테쯔로 심푸꾸
히데끼 베스호
준꼬 하야시
아사미 세이노
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에또 다께또시
미쓰비시 가세이 가부끼가이샤
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Publication of KR910016694A publication Critical patent/KR910016694A/ko

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/44—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/59—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with at least one of the bonds being to sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

티오카르바모일아세토니트릴 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 일반식(I)으로 표시되는 티오카르바모일아세토니트릴 화합물:
    상기식에서, R1은 수소 C1내지 C6알킬, C3내지 C6시클로알킬 또는 -(CH2)n-A(여기서 A는, C1내지 C6알킬 및 할로겐으로 부터 선정된 한개 이상의 치환기로 치환될 수 있는, C6내지 C12아릴, 5-또는 6-원 헤테로시클릭기 또는 9 또는 10개 원자로 구성된 융합 헤테로시클릭 기이고 또 n은 0 또는 1 내지 6의 정수임)이고, R2는 C1내지 C10알킬이며, 또 Ar은 C1내지 C6알콕시, C2내지 C7알킬카르보닐, C7내지 C13아릴카르보닐, C1내지 C6알킬아미노, C2내지 C6디알킬아미노, 아미노, 포르밀아미노, C2내지 C7알킬카르보닐아미노, 할로겐, 시아노, 니트로, 히드록실, C1내지 C6알킬티오, C6내지 C12아릴티오, C1내 C6알킬술피닐, C6내지 C12아릴술피닐, C1내지 C6알킬술포닐, C6내지 C12아릴술피닐, C1내지 C6내지 C12아릴술포닐, 아미노술포닐, C1내지 C6알킬아미노술포닐, C2내지 C6디알킬아미노술포닐, 트리풀루오르메틸 및 아미다졸릴로 구성된 군으로 부터 선정된 한개 이상의 치환기로 치환될 수 있는, 아릴, 5-또는 6-원 헤테로시클릭 기 또는 융합 헤테로시클릭 기임.
  2. 제 1항에 있어서, A또는 Ar로 표시되는 상기 5-원 또는 6-원 헤테로시클릭 잔기는 피롤, 이미다졸, 피라졸, 피리딘, 피라진, 피리민딘, 피리다진, 티오펜, 치아졸, 이소티아졸, 푸란 옥사졸 또는 이소옥사졸을 형성하고, 또 9또는 10개 원자로 구성된 상기의 융합 헤테로시클릴, 고리 잔기는 인폴리진, 인돌, 이소인돌, 퀴눌린, 이소퀴놀린, 벤조티오펜, 이소벤조펜, 벤조티아졸, 이소벤조티아졸, 벤조푸란, 이소벤조푸란, 벤조옥사졸 또는 이소벤조옥사졸 고리를 형성하는 화합물.
  3. 제2항에 있어서, R2가 C1내지 C6알킬인 화합물.
  4. 제3항에 있어서, R1이 수소, C1내지 C6알킬, C3내지 C6시클로알킬 또는-(CH2)n-A(이때 A는, C1내지 C3알킬 및 할로겐으로 구성된 군으로 부터 선정된 한개 이상의 치환기에 의해 치환될 수 있는, 페닐, 피리딜, 티엔임, 벤즈이미다졸릴 또는 벤조티아졸릴이고, 또 n'는 0 또는 1내지 3의 정수임)인 화합물.
  5. 제4항에 있어서, Ar은 C1내지 C6알킬,C1내지 C6알콕시, C2내지 C7알킬카르보닐, C7내지 C13아릴카르보닐, C7내지 C6알킬아미노, C2내지 C6디알킬아니모, 아니모, 포르밀아미노, C2내지 C7알킬카르보닐아미노, 할로겐, 시아노, 니트로, 히드록실, C1내지 C6알킬티오, C6내지 C12아릴티오, C1내지 C6알킬술피닐, C6내지 C12아릴술피닐, C1내지 C6알킬아미노술포닐, C2내지 C6디알킬아미노술포닐, 트리플루오르메틸 및 이미다졸리로 구성된 군으로 부터 선정된 한개 이상의 치환기에 의해 치환될 수 있는, 페닐, 나프틸, 피리딜, 티엔일, 피롤리, 이미다졸림, 피라진일, 피리미딘일, 인돌릴, 벤조티아졸릴, 벤즈이미다졸릴 또는 퀴놀릴인 화합물.
  6. 제5항에 있어서, R1가 수소, C1내지 C6알킬, C5내지 C6시클로알킬, 또는 한개 이상의 할로겐 원자를 가질수 있는 페닐, 벤질, 펜에틸 또는 페닐프로필인 화합물.
  7. 제6항에 있어서, Ar은 C1내지 C6알킬, C1내지 C6알콕시, 아미노, 할로겐 시아노, 니트로, C1내지 C6알킬티오, C6내지 C12아릴술포닐, 아미노술포닐, 트리플루오로메틸 및 이미다졸릴로 구성된 군으로 부터 선정된 한개 이상의 치환기로 치환될 수 있는, 페닐, 나프틸, 피리딜, 티엔일, 피롤릴, 벤조티아졸릴 피롤릴 또는 벤즈이미다 졸릴인 화합물.
  8. 활성 성분으로서 제1항에 따른 화합물 한개 이상의 및 약제학적으로 허용되는 담체를 포함하는 약제 조성물.
  9. 제8항에 있어서, 항 고혈압 처리에 사용되는 약제 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910003553A 1990-03-05 1991-03-05 티오카르바모일아세토니트릴 화합물 KR910016694A (ko)

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US (1) US5246958A (ko)
EP (1) EP0445698B1 (ko)
JP (1) JPH04211048A (ko)
KR (1) KR910016694A (ko)
AT (1) ATE107630T1 (ko)
CA (1) CA2037483A1 (ko)
DE (1) DE69102563T2 (ko)
ES (1) ES2055476T3 (ko)
TW (1) TW199142B (ko)

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WO2015091343A1 (en) * 2013-12-20 2015-06-25 Basf Se Thioamides and amides for controlling animal pests

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122087C (ko) *
DD122087A1 (ko) * 1975-09-25 1976-09-12
FR2488609A1 (fr) * 1980-08-18 1982-02-19 Rhone Poulenc Ind Nouveaux derives de la thioformamide, leur preparation et les medicaments qui les contiennent
FR2511371A1 (fr) * 1981-08-11 1983-02-18 Rhone Poulenc Sante Nouveaux nitriles heterocycliques, leur preparation et leur utilisation pour la preparation de medicaments
FR2528849B1 (fr) * 1982-06-17 1985-06-21 Rhone Poulenc Sante Nouveaux derives de la thioformamide, leur preparation et les medicaments qui les contiennent
US4466866A (en) * 1983-06-16 1984-08-21 Rhone-Poulenc Sante Electrochemical process for the preparation of sulphoxides of thioformamide derivatives, which are useful as medicaments
GB8619432D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
GB8729521D0 (en) * 1987-12-18 1988-02-03 May & Baker Ltd New compositions of matter
GB8729522D0 (en) * 1987-12-18 1988-02-03 May & Baker Ltd New compositions of matter
GB8801300D0 (en) * 1988-01-21 1988-02-17 May & Baker Ltd New compositions of matter

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US5246958A (en) 1993-09-21
JPH04211048A (ja) 1992-08-03
EP0445698B1 (en) 1994-06-22
DE69102563D1 (de) 1994-07-28
DE69102563T2 (de) 1994-11-17
TW199142B (ko) 1993-02-01
ES2055476T3 (es) 1994-08-16
EP0445698A1 (en) 1991-09-11
ATE107630T1 (de) 1994-07-15

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