ZA903478B - Heterocyclicguanidines as 5ht3 antagonists - Google Patents

Heterocyclicguanidines as 5ht3 antagonists

Info

Publication number
ZA903478B
ZA903478B ZA903478A ZA903478A ZA903478B ZA 903478 B ZA903478 B ZA 903478B ZA 903478 A ZA903478 A ZA 903478A ZA 903478 A ZA903478 A ZA 903478A ZA 903478 B ZA903478 B ZA 903478B
Authority
ZA
South Africa
Prior art keywords
methyl
carbon atoms
indol
hydrogen
heterocyclicguanidines
Prior art date
Application number
ZA903478A
Other languages
English (en)
Inventor
Arthur Adam Nagel
Adam Nagel Arthur
James Patrick Rizzi
Patrick Rizzi James
Terry Jay Rosen
Jay Rosen Terry
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA903478B publication Critical patent/ZA903478B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
ZA903478A 1989-05-19 1990-05-08 Heterocyclicguanidines as 5ht3 antagonists ZA903478B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/349,189 US4963689A (en) 1989-05-19 1989-05-19 Heterocyclicguanidines as 5HT3 antagonists

Publications (1)

Publication Number Publication Date
ZA903478B true ZA903478B (en) 1991-12-24

Family

ID=23371270

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA903478A ZA903478B (en) 1989-05-19 1990-05-08 Heterocyclicguanidines as 5ht3 antagonists

Country Status (19)

Country Link
US (1) US4963689A (xx)
EP (1) EP0397364B1 (xx)
JP (1) JPH0635454B2 (xx)
KR (1) KR920003927B1 (xx)
AT (1) ATE92062T1 (xx)
AU (1) AU615385B2 (xx)
CA (1) CA2016182C (xx)
DE (1) DE69002384T2 (xx)
DK (1) DK0397364T3 (xx)
ES (1) ES2058795T3 (xx)
FI (1) FI902291A0 (xx)
HU (1) HUT58063A (xx)
IE (1) IE62935B1 (xx)
IL (1) IL94254A (xx)
MY (1) MY105555A (xx)
NO (1) NO902029L (xx)
NZ (1) NZ233576A (xx)
PT (1) PT93979B (xx)
ZA (1) ZA903478B (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5140034A (en) * 1989-03-14 1992-08-18 Merck Sharp & Dohme Ltd. Five-membered ring systems with bonded imidazolyl ring substituents
RU2098418C1 (ru) * 1992-09-14 1997-12-10 Яманоути Фармасьютикал Ко., Лтд. Конденсированное производное тиазола или его фармацевтически приемлемая соль, фармацевтическая композиция, проявляющая активность агониста 5-нт*003-рецептора на его основе
WO1995024399A1 (fr) * 1994-03-11 1995-09-14 Yamanouchi Pharmaceutical Co., Ltd. Agoniste de recepteur 5-ht3, nouveau derive de thiazole et intermediaire destine a son obtention
US5887415A (en) * 1995-05-11 1999-03-30 Bernard Matthews Plc Cooked, extruded meat product comprising additive
US5811425A (en) * 1997-03-04 1998-09-22 Abbott Laboratories Heterocyclic compounds as COX-2 inhibitors
DE102005027193A1 (de) * 2005-06-06 2006-12-07 Wilhelm Stahlecker Gmbh Zwillingseinheit mit zwei Streckwerken für eine Spinnmaschine
EP2253316B1 (en) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
LT2432467T (lt) 2009-05-20 2018-04-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonino 5-ht3 receptoriaus antagonistai, skirti panaudoti pažeidimų sukeltų vestibiuliarinių sutrikimų gydymui
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1031165A (en) * 1965-08-18 1966-05-25 Wellcome Found Guanidines, isoureas and isothioureas
GB1305549A (xx) * 1969-10-29 1973-02-07
DE2739723A1 (de) * 1977-09-03 1979-03-08 Merck Patent Gmbh 2-guanidinomethyl-indoline und verfahren zu ihrer herstellung
US4220654A (en) * 1979-06-04 1980-09-02 Merck & Co., Inc. Cyclic imidazole cyanoguanidines
US4563527A (en) * 1984-07-19 1986-01-07 Torii & Co., Ltd. Amidine compounds

Also Published As

Publication number Publication date
FI902291A0 (fi) 1990-05-08
IE901664L (en) 1990-11-09
US4963689A (en) 1990-10-16
EP0397364A1 (en) 1990-11-14
AU615385B2 (en) 1991-09-26
CA2016182C (en) 1996-03-12
IL94254A (en) 1994-05-30
HU902976D0 (en) 1990-09-28
MY105555A (en) 1994-10-31
ES2058795T3 (es) 1994-11-01
NO902029L (no) 1990-11-12
AU5476790A (en) 1990-11-15
KR920003927B1 (ko) 1992-05-18
IE62935B1 (en) 1995-03-08
ATE92062T1 (de) 1993-08-15
NO902029D0 (no) 1990-05-08
PT93979B (pt) 1996-11-29
CA2016182A1 (en) 1990-11-09
DE69002384D1 (de) 1993-09-02
HUT58063A (en) 1992-01-28
EP0397364B1 (en) 1993-07-28
PT93979A (pt) 1991-01-08
DE69002384T2 (de) 1993-11-18
JPH0635454B2 (ja) 1994-05-11
NZ233576A (en) 1991-06-25
JPH0311070A (ja) 1991-01-18
KR900018054A (ko) 1990-12-20
DK0397364T3 (da) 1993-09-27

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