DE68909855D1 - 2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydroisochinolin-Derivate, ihre Herstellung und ihre therapeutische Verwendung. - Google Patents

2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydroisochinolin-Derivate, ihre Herstellung und ihre therapeutische Verwendung.

Info

Publication number
DE68909855D1
DE68909855D1 DE89400306T DE68909855T DE68909855D1 DE 68909855 D1 DE68909855 D1 DE 68909855D1 DE 89400306 T DE89400306 T DE 89400306T DE 68909855 T DE68909855 T DE 68909855T DE 68909855 D1 DE68909855 D1 DE 68909855D1
Authority
DE
Germany
Prior art keywords
methyl
piperidinyl
preparation
group
therapeutic use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE89400306T
Other languages
English (en)
Inventor
Pascal George
Mireille Sevrin
Christian Maloizel
Arlette Tixidre
Jacques Froissant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8809447A external-priority patent/FR2634204B2/fr
Application filed by Synthelabo SA filed Critical Synthelabo SA
Application granted granted Critical
Publication of DE68909855D1 publication Critical patent/DE68909855D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE89400306T 1988-07-12 1989-02-03 2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydroisochinolin-Derivate, ihre Herstellung und ihre therapeutische Verwendung. Expired - Lifetime DE68909855D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8809447A FR2634204B2 (fr) 1987-08-07 1988-07-12 Derives de ((piperidinyl-4)methyl)-2 tetrahydro-1,2,3,4 isoquinoleines, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
DE68909855D1 true DE68909855D1 (de) 1993-11-18

Family

ID=9368349

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89400306T Expired - Lifetime DE68909855D1 (de) 1988-07-12 1989-02-03 2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydroisochinolin-Derivate, ihre Herstellung und ihre therapeutische Verwendung.

Country Status (15)

Country Link
US (1) US4925850A (de)
EP (1) EP0351255B1 (de)
JP (1) JPH0225481A (de)
KR (1) KR900001676A (de)
AT (1) ATE95816T1 (de)
AU (1) AU606778B2 (de)
DE (1) DE68909855D1 (de)
DK (1) DK50089A (de)
FI (1) FI890520A (de)
HU (1) HU201543B (de)
IL (1) IL89156A (de)
NO (1) NO171786C (de)
NZ (1) NZ227853A (de)
PT (1) PT89643B (de)
ZA (1) ZA89905B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0306375A1 (de) * 1987-08-07 1989-03-08 Synthelabo 2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydrochinolin-Derivate, ihre Herstellung und ihre therapeutische Verwendung
FR2661178B1 (fr) * 1990-04-24 1993-03-12 Synthelabo Derives de [(tetrahydro-1,2,3,4 isoquinoleinyl-2)methyl]-4 piperidinecarboxylates-1 d'alkyle, leur preparation et leur application en therapeutique.
US5132311A (en) * 1990-06-27 1992-07-21 G. D. Searle & Co. Cyanoquanidine type III antiarrhythmic agents and use
FR2747386B1 (fr) * 1996-04-12 1998-05-15 Synthelabo Derives de 3-[(1,2,3,4-tetrahydroisoquinolein-2-yl)methyl] -8-azabicyclo [3.2.1] octane, leur preparation et leur application en therapeutique
AU4204697A (en) * 1996-08-14 1998-03-06 Smithkline Beecham Plc Tetrahydroisoquinoline derivatives and their pharmaceutical use
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
HUP0104280A3 (en) 1998-10-08 2002-07-29 Smithkline Beecham Plc Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors, process for their preparation, medicaments containing them
DE10060176B4 (de) 2000-12-04 2008-06-19 Precitec Kg Laserbearbeitungskopf
KR101042208B1 (ko) * 2008-09-26 2011-06-20 현대종합금속 주식회사 셀프 쉴디드(ｓｅｌｆ－ｓｈｉｅｌｄｅｄ) 아크 용접 플럭스 충전 와이어
NZ597219A (en) 2009-06-26 2013-05-31 Sanofi Sa Novel fumarate salts of a histamine h3 receptor antagonist

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670041A1 (de) * 1967-03-14 1972-03-02 American Home Prod Isoindole und Isoindoline
FR7607M (de) * 1968-04-25 1970-01-19
GB1250719A (de) * 1969-03-19 1971-10-20
US3836536A (en) * 1972-06-08 1974-09-17 Warner Lambert Co 1,2,3,4-tetrahydro-3-aminomethyliso-quinolines
FR2426046A1 (fr) * 1978-05-18 1979-12-14 Synthelabo Derive de tetrahydro-isoquinoleine, sa preparation et son application en therapeutique
US4220778A (en) * 1978-10-30 1980-09-02 G. D. Searle & Co. 8-Aryl-1,2,3,4-tetrahydroisoquinoline and derivatives thereof
US4766131A (en) * 1980-10-17 1988-08-23 Pennwalt Corporation 2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0306375A1 (de) * 1987-08-07 1989-03-08 Synthelabo 2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydrochinolin-Derivate, ihre Herstellung und ihre therapeutische Verwendung

Also Published As

Publication number Publication date
NZ227853A (en) 1990-06-26
AU606778B2 (en) 1991-02-14
KR900001676A (ko) 1990-02-27
PT89643B (pt) 1994-02-28
PT89643A (pt) 1989-10-04
EP0351255A2 (de) 1990-01-17
DK50089D0 (da) 1989-02-03
DK50089A (da) 1990-01-13
HU201543B (en) 1990-11-28
NO890440L (no) 1990-01-15
IL89156A (en) 1993-05-13
NO171786B (no) 1993-01-25
JPH0225481A (ja) 1990-01-26
AU2961789A (en) 1990-01-18
NO890440D0 (no) 1989-02-03
FI890520A (fi) 1990-01-13
ZA89905B (en) 1989-10-25
FI890520A0 (fi) 1989-02-03
ATE95816T1 (de) 1993-10-15
EP0351255A3 (en) 1990-05-02
US4925850A (en) 1990-05-15
EP0351255B1 (de) 1993-10-13
HUT50327A (en) 1990-01-29
NO171786C (no) 1993-05-05
IL89156A0 (en) 1989-09-10

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