DE3888756D1 - Carbamoylpyrrolidonderivate, ihre Verwendung und Herstellung. - Google Patents

Carbamoylpyrrolidonderivate, ihre Verwendung und Herstellung.

Info

Publication number
DE3888756D1
DE3888756D1 DE88307723T DE3888756T DE3888756D1 DE 3888756 D1 DE3888756 D1 DE 3888756D1 DE 88307723 T DE88307723 T DE 88307723T DE 3888756 T DE3888756 T DE 3888756T DE 3888756 D1 DE3888756 D1 DE 3888756D1
Authority
DE
Germany
Prior art keywords
methoxy
halogen
methyl group
phenyl
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88307723T
Other languages
English (en)
Other versions
DE3888756T2 (de
Inventor
Hiromu Matsumura
Akira Matsushita
Toshisada Yano
Masami Eigyo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of DE3888756D1 publication Critical patent/DE3888756D1/de
Publication of DE3888756T2 publication Critical patent/DE3888756T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE3888756T 1987-08-19 1988-08-19 Carbamoylpyrrolidonderivate, ihre Verwendung und Herstellung. Expired - Fee Related DE3888756T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20595687 1987-08-19

Publications (2)

Publication Number Publication Date
DE3888756D1 true DE3888756D1 (de) 1994-05-05
DE3888756T2 DE3888756T2 (de) 1994-07-14

Family

ID=16515486

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3888756T Expired - Fee Related DE3888756T2 (de) 1987-08-19 1988-08-19 Carbamoylpyrrolidonderivate, ihre Verwendung und Herstellung.

Country Status (9)

Country Link
US (2) US4977167A (de)
EP (1) EP0304330B1 (de)
KR (1) KR900006990B1 (de)
AT (1) ATE103592T1 (de)
AU (1) AU612170B2 (de)
CA (1) CA1305148C (de)
DE (1) DE3888756T2 (de)
DK (1) DK464288A (de)
ES (1) ES2061663T3 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68916198T2 (de) * 1988-04-15 1994-09-22 Taiho Pharmaceutical Co Ltd Carbamoyl-2-Pyrrolidinonverbindungen.
JP2803882B2 (ja) * 1990-02-20 1998-09-24 日清製粉株式会社 １―フエノキシカルボニル―２―ピロリジノン誘導体
US5243051A (en) * 1990-03-05 1993-09-07 Shionigi & Co., Ltd. Tetrahydropyridine derivatives
US5149817A (en) * 1990-03-05 1992-09-22 Shionogi & Co., Ltd. Teirahydropyridine derivatives
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
ES2084763T3 (es) * 1990-10-23 1996-05-16 Akzo Nobel Nv 4-(4- o 6-(2-trifluormetil piridinil))1-piperazinilalquilo lactamas sustituidas.
JP3038032B2 (ja) * 1991-03-25 2000-05-08 日清製粉株式会社 血小板凝集抑制薬
US5153316A (en) * 1991-06-04 1992-10-06 Crouse Gary D Intermediates for herbicidal phenylimidazolones
CA2100641A1 (en) * 1992-07-23 1994-01-24 Hiromu Matsumura Novel piperidine derivatives and process for preparation thereof
FR2703354B1 (fr) * 1993-03-31 1995-06-30 Lafon Labor Derives de 1, 2, 5, 6-tetrahydropyridine, leur procede de preparation et leurs applications en therapeutique.
JP3719612B2 (ja) * 1993-06-14 2005-11-24 塩野義製薬株式会社 ヘテロ環を含有する尿素誘導体
AU4772497A (en) * 1996-10-31 1998-05-22 Novo Nordisk A/S Constrained somatostatin agonists and antagonists
SE0004780D0 (sv) 2000-12-22 2000-12-22 Jordanian Pharmaceutical Mfg & Novel compunds
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
US6727277B1 (en) 2002-11-12 2004-04-27 Kansas State University Research Foundation Compounds affecting cholesterol absorption
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
WO2010138869A1 (en) 2009-05-29 2010-12-02 The Trustees Of Columbia University In The City Of New York Modulation of phospholipase d for the treatment of neurodegenerative disorders
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US9598387B2 (en) 2012-10-11 2017-03-21 Southern Research Institute Urea and amide derivatives of aminoalkylpiperazines and use thereof
CN103360337B (zh) * 2013-07-11 2016-04-27 浙江海蓝化工集团有限公司 一种2-巯基-5-甲基-1,3,4-噻二唑的制备方法
CN107074893A (zh) * 2014-08-19 2017-08-18 斯特雷特马克控股股份公司 用于合成杂环氧化氢膦的方法
SG11201901452UA (en) * 2016-09-01 2019-03-28 Mebias Discovery Llc Substituted ureas and methods of making and using same
AU2018234001B2 (en) * 2017-03-13 2022-01-06 Sumitomo Pharma Co., Ltd. 2,6-disubstituted pyridine derivative

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2829146A (en) * 1956-07-30 1958-04-01 Monsanto Chemicals Pyrrolidine compounds
IT1045043B (it) * 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
BE864269A (fr) * 1977-03-03 1978-06-16 Parke Davis & Co Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire
CU21107A3 (es) * 1978-02-10 1988-02-01 Hoffmann La Roche Pyrrolidines derivatives
EP0089900B1 (de) * 1982-03-24 1985-12-27 Prodes S.A. N-((2-oxo-1-pyrrolidinyl)acetyl)Piperazine, Verfahren zu ihrer Herstellung sowie ihre Salze und ihre Verwendung in pharmazeutischen Zubereitungen
DE3420193A1 (de) * 1984-05-30 1985-12-05 Boehringer Ingelheim KG, 6507 Ingelheim Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel
IT1224168B (it) * 1986-08-01 1990-09-26 Finanziaria R F Spa Ora Finanz Derivati del pirrolidin-2-one ad attivita' nootropa
US4791112A (en) * 1987-02-02 1988-12-13 The Boc Group, Inc. N-heterocyclic-N-(4-piperidyl)amides and pharmaceutical compositions and methods employing such compounds

Also Published As

Publication number Publication date
KR900006990B1 (ko) 1990-09-25
US5120733A (en) 1992-06-09
DE3888756T2 (de) 1994-07-14
CA1305148C (en) 1992-07-14
ES2061663T3 (es) 1994-12-16
KR890003742A (ko) 1989-04-17
US4977167A (en) 1990-12-11
DK464288A (da) 1989-02-20
DK464288D0 (da) 1988-08-18
EP0304330B1 (de) 1994-03-30
AU2104388A (en) 1989-03-23
AU612170B2 (en) 1991-07-04
EP0304330A1 (de) 1989-02-22
ATE103592T1 (de) 1994-04-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee