IT1224168B - Derivati del pirrolidin-2-one ad attivita' nootropa - Google Patents

Derivati del pirrolidin-2-one ad attivita' nootropa

Info

Publication number
IT1224168B
IT1224168B IT21397/86A IT2139786A IT1224168B IT 1224168 B IT1224168 B IT 1224168B IT 21397/86 A IT21397/86 A IT 21397/86A IT 2139786 A IT2139786 A IT 2139786A IT 1224168 B IT1224168 B IT 1224168B
Authority
IT
Italy
Prior art keywords
pyrolidin
derivatives
nootropic activity
nootropic
activity
Prior art date
Application number
IT21397/86A
Other languages
English (en)
Other versions
IT8621397A0 (it
Inventor
Silvia Scolastico
Original Assignee
Finanziaria R F Spa Ora Finanz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Finanziaria R F Spa Ora Finanz filed Critical Finanziaria R F Spa Ora Finanz
Priority to IT21397/86A priority Critical patent/IT1224168B/it
Publication of IT8621397A0 publication Critical patent/IT8621397A0/it
Priority to US07/079,172 priority patent/US4788212A/en
Priority to DE198787111127T priority patent/DE255149T1/de
Priority to JP62190581A priority patent/JPS6341454A/ja
Priority to ES87111127T priority patent/ES2003063A4/es
Priority to EP87111127A priority patent/EP0255149A1/en
Priority to GR88300122T priority patent/GR880300122T1/el
Application granted granted Critical
Publication of IT1224168B publication Critical patent/IT1224168B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
IT21397/86A 1986-08-01 1986-08-01 Derivati del pirrolidin-2-one ad attivita' nootropa IT1224168B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT21397/86A IT1224168B (it) 1986-08-01 1986-08-01 Derivati del pirrolidin-2-one ad attivita' nootropa
US07/079,172 US4788212A (en) 1986-08-01 1987-07-29 Pyrrolidin-2-one derivatives having nootropic activity
DE198787111127T DE255149T1 (de) 1986-08-01 1987-07-31 Pyrrolidin-2-on-derivate mit nootroper aktivitaet.
JP62190581A JPS6341454A (ja) 1986-08-01 1987-07-31 向知恵作用のあるピロリジン−２−オン誘導体
ES87111127T ES2003063A4 (es) 1986-08-01 1987-07-31 Derivados de pirrolidin-2-ona, que tengan actividad nootropica.
EP87111127A EP0255149A1 (en) 1986-08-01 1987-07-31 Pyrrolidin-2-one derivatives having nootropic activity
GR88300122T GR880300122T1 (en) 1986-08-01 1988-12-16 Pyrrolidin-2-one derivatives having nootropic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21397/86A IT1224168B (it) 1986-08-01 1986-08-01 Derivati del pirrolidin-2-one ad attivita' nootropa

Publications (2)

Publication Number Publication Date
IT8621397A0 IT8621397A0 (it) 1986-08-01
IT1224168B true IT1224168B (it) 1990-09-26

Family

ID=11181147

Family Applications (1)

Application Number Title Priority Date Filing Date
IT21397/86A IT1224168B (it) 1986-08-01 1986-08-01 Derivati del pirrolidin-2-one ad attivita' nootropa

Country Status (7)

Country Link
US (1) US4788212A (it)
EP (1) EP0255149A1 (it)
JP (1) JPS6341454A (it)
DE (1) DE255149T1 (it)
ES (1) ES2003063A4 (it)
GR (1) GR880300122T1 (it)
IT (1) IT1224168B (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH075546B2 (ja) * 1987-08-19 1995-01-25 塩野義製薬株式会社 カルバモイルピロリドン誘導体
CA1305148C (en) * 1987-08-19 1992-07-14 Hiromu Matsumura Carbamoylpyrrolidone derivatives and drugs for senile dementia
AU4200489A (en) * 1988-08-26 1990-03-23 Sepracor, Inc. Derivatives and precursors of captopril and its analogues
US5237073A (en) * 1988-08-26 1993-08-17 Sepracor, Inc. Derivatives and precursors of captopril and its analogues
JPH02155683A (ja) * 1988-12-07 1990-06-14 Nec Corp ファクシミリ装置
HUT53607A (en) * 1989-01-17 1990-11-28 Hoffmann La Roche Process for production of derivatives of cyclohexan-acetamid
IT1231477B (it) * 1989-07-12 1991-12-07 Sigma Tau Ind Farmaceuti (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1039113A (en) * 1964-08-06 1966-08-17 Ucb Sa New n-substituted lactams
IT1045043B (it) * 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique

Also Published As

Publication number Publication date
JPS6341454A (ja) 1988-02-22
IT8621397A0 (it) 1986-08-01
US4788212A (en) 1988-11-29
EP0255149A1 (en) 1988-02-03
DE255149T1 (de) 1988-09-22
ES2003063A4 (es) 1988-10-16
GR880300122T1 (en) 1988-12-16

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