KR900001676A - 2-[(4- 피페리디닐)메틸)-1,2,3,4-테트라히드로이소퀴놀린, 그의 제법 및 치료에의 이용 - Google Patents
2-[(4- 피페리디닐)메틸)-1,2,3,4-테트라히드로이소퀴놀린, 그의 제법 및 치료에의 이용 Download PDFInfo
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- KR900001676A KR900001676A KR1019890001304A KR890001304A KR900001676A KR 900001676 A KR900001676 A KR 900001676A KR 1019890001304 A KR1019890001304 A KR 1019890001304A KR 890001304 A KR890001304 A KR 890001304A KR 900001676 A KR900001676 A KR 900001676A
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- South Korea
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 다음 일반식(I)의 화합물 및 그의 산부가염.상기식에서, X는 수소원자 또는 메틸 또는 메톡시기를 나타내며, Y는 할로겐원자 또는 메틸 또는 메톡시기를 나타내고, R은 일반식-Z-R′의 기를 나타내는데 여기서 Z는 -CH2-기 또는 -CO-기를 나타내며, R′는 할로겐원자 및 트리플루오로 메틸, 선형 또는 분기형(C1-C3)알킬, 그리고 선형 또는 분기형(C1-C3)알콕시기로 부터 선택된 1 내지 3개의 치환체를 임의적으로 지니는 페닐기를 나타낸다.
- 일반식(II)(상기식에서 X와 Y는 제 1 항에 정의된 것과 같다)의 1,2,3,4-테트라히드로 이소퀴놀린을 일반식(III)(상기식에서 Tos는 토실기를 나타내며 R′는 제 1 항에 정의된 것과 같다)의 토실레이트와, 디메틸포름아미드, 톨루엔, 또는 크실렌과 같은 비활성용매의 부재 또는 존재하에 20 내지 150℃의 온도에서 그리고 임의적으로 3차 아민과 같은 유기염기, 또는 알칼리금속 탄산염 또는 중탄산염과 같은 무기염기의 존재하에 반응시켜, 따라서,일반식(Ia)의 화합물을 걷은 다음, 만일 Z가 -CH3-기를 나타내는 일반식(I)의 화합물을 제조하는 것이 요구된다면, 일반식(Ia)의 화합물을 계속해서 수소화알루미늄리튬, 수소화알루미늄, 디보란/테트라히드로푸란 착체 또는 디보란/황화메틸착체와 같은 단순 또는 착체 수소화 붕소 또는 알루미늄으로 디에틸에테르, 테트라히드로푸란 또는 디옥산과 같은 에테르성용매에서 20 내지 100℃의 온도에서 환원시키는 것을 특징으로하는 제 1 항에 따르는 화합물의 제조방법.
- 약학적 부형제와 조합하여 제 1 항에 따르는 화합물을 함유하는 것을 특징으로 하는 약학조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8809447A FR2634204B2 (fr) | 1987-08-07 | 1988-07-12 | Derives de ((piperidinyl-4)methyl)-2 tetrahydro-1,2,3,4 isoquinoleines, leur preparation et leur application en therapeutique |
FR8809447 | 1988-07-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR900001676A true KR900001676A (ko) | 1990-02-27 |
Family
ID=9368349
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890001304A KR900001676A (ko) | 1988-07-12 | 1989-02-04 | 2-[(4- 피페리디닐)메틸)-1,2,3,4-테트라히드로이소퀴놀린, 그의 제법 및 치료에의 이용 |
Country Status (15)
Country | Link |
---|---|
US (1) | US4925850A (ko) |
EP (1) | EP0351255B1 (ko) |
JP (1) | JPH0225481A (ko) |
KR (1) | KR900001676A (ko) |
AT (1) | ATE95816T1 (ko) |
AU (1) | AU606778B2 (ko) |
DE (1) | DE68909855D1 (ko) |
DK (1) | DK50089A (ko) |
FI (1) | FI890520A (ko) |
HU (1) | HU201543B (ko) |
IL (1) | IL89156A (ko) |
NO (1) | NO171786C (ko) |
NZ (1) | NZ227853A (ko) |
PT (1) | PT89643B (ko) |
ZA (1) | ZA89905B (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101042208B1 (ko) * | 2008-09-26 | 2011-06-20 | 현대종합금속 주식회사 | 셀프 쉴디드(self-shielded) 아크 용접 플럭스 충전 와이어 |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3717561A1 (de) * | 1987-05-25 | 1988-12-08 | Thomae Gmbh Dr K | Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
EP0306375A1 (fr) * | 1987-08-07 | 1989-03-08 | Synthelabo | Dérivés de[(pipéridinyl-4)méthyl]-2 tétrahydro-1,2,3,4 isoquinoléine, leur préparation et leur application en thérapeutique |
FR2661178B1 (fr) * | 1990-04-24 | 1993-03-12 | Synthelabo | Derives de [(tetrahydro-1,2,3,4 isoquinoleinyl-2)methyl]-4 piperidinecarboxylates-1 d'alkyle, leur preparation et leur application en therapeutique. |
US5132311A (en) * | 1990-06-27 | 1992-07-21 | G. D. Searle & Co. | Cyanoquanidine type III antiarrhythmic agents and use |
FR2747386B1 (fr) * | 1996-04-12 | 1998-05-15 | Synthelabo | Derives de 3-[(1,2,3,4-tetrahydroisoquinolein-2-yl)methyl] -8-azabicyclo [3.2.1] octane, leur preparation et leur application en therapeutique |
CA2263284A1 (en) * | 1996-08-14 | 1998-02-19 | Smithkline Beecham P.L.C. | Tetrahydroisoquinoline derivatives and their pharmaceutical use |
GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
DE69929704T2 (de) | 1998-10-08 | 2006-07-20 | Smithkline Beecham Plc, Brentford | Tetrahydrobenzazepin-derivate verwendbar als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel) |
DE10060176B4 (de) | 2000-12-04 | 2008-06-19 | Precitec Kg | Laserbearbeitungskopf |
KR101804749B1 (ko) | 2009-06-26 | 2017-12-05 | 사노피 | 히스타민 h3 수용체 길항제의 신규 푸마레이트 염 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670041A1 (de) * | 1967-03-14 | 1972-03-02 | American Home Prod | Isoindole und Isoindoline |
FR7607M (ko) * | 1968-04-25 | 1970-01-19 | ||
GB1250719A (ko) * | 1969-03-19 | 1971-10-20 | ||
US3836536A (en) * | 1972-06-08 | 1974-09-17 | Warner Lambert Co | 1,2,3,4-tetrahydro-3-aminomethyliso-quinolines |
FR2426046A1 (fr) * | 1978-05-18 | 1979-12-14 | Synthelabo | Derive de tetrahydro-isoquinoleine, sa preparation et son application en therapeutique |
US4220778A (en) * | 1978-10-30 | 1980-09-02 | G. D. Searle & Co. | 8-Aryl-1,2,3,4-tetrahydroisoquinoline and derivatives thereof |
US4766131A (en) * | 1980-10-17 | 1988-08-23 | Pennwalt Corporation | 2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics |
DE3717561A1 (de) * | 1987-05-25 | 1988-12-08 | Thomae Gmbh Dr K | Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
EP0306375A1 (fr) * | 1987-08-07 | 1989-03-08 | Synthelabo | Dérivés de[(pipéridinyl-4)méthyl]-2 tétrahydro-1,2,3,4 isoquinoléine, leur préparation et leur application en thérapeutique |
-
1989
- 1989-02-02 IL IL89156A patent/IL89156A/xx not_active IP Right Cessation
- 1989-02-03 AU AU29617/89A patent/AU606778B2/en not_active Ceased
- 1989-02-03 DK DK050089A patent/DK50089A/da not_active Application Discontinuation
- 1989-02-03 NO NO890440A patent/NO171786C/no unknown
- 1989-02-03 NZ NZ227853A patent/NZ227853A/en unknown
- 1989-02-03 EP EP89400306A patent/EP0351255B1/fr not_active Expired - Lifetime
- 1989-02-03 AT AT89400306T patent/ATE95816T1/de not_active IP Right Cessation
- 1989-02-03 DE DE89400306T patent/DE68909855D1/de not_active Expired - Lifetime
- 1989-02-03 PT PT89643A patent/PT89643B/pt active IP Right Grant
- 1989-02-03 FI FI890520A patent/FI890520A/fi not_active Application Discontinuation
- 1989-02-04 KR KR1019890001304A patent/KR900001676A/ko not_active Application Discontinuation
- 1989-02-06 HU HU89565A patent/HU201543B/hu not_active IP Right Cessation
- 1989-02-06 JP JP1027326A patent/JPH0225481A/ja active Pending
- 1989-02-06 ZA ZA89905A patent/ZA89905B/xx unknown
- 1989-02-06 US US07/306,497 patent/US4925850A/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101042208B1 (ko) * | 2008-09-26 | 2011-06-20 | 현대종합금속 주식회사 | 셀프 쉴디드(self-shielded) 아크 용접 플럭스 충전 와이어 |
Also Published As
Publication number | Publication date |
---|---|
DE68909855D1 (de) | 1993-11-18 |
EP0351255A3 (en) | 1990-05-02 |
AU2961789A (en) | 1990-01-18 |
NO890440D0 (no) | 1989-02-03 |
HU201543B (en) | 1990-11-28 |
NO890440L (no) | 1990-01-15 |
FI890520A0 (fi) | 1989-02-03 |
ZA89905B (en) | 1989-10-25 |
FI890520A (fi) | 1990-01-13 |
EP0351255A2 (fr) | 1990-01-17 |
NO171786B (no) | 1993-01-25 |
NO171786C (no) | 1993-05-05 |
DK50089D0 (da) | 1989-02-03 |
EP0351255B1 (fr) | 1993-10-13 |
US4925850A (en) | 1990-05-15 |
HUT50327A (en) | 1990-01-29 |
IL89156A (en) | 1993-05-13 |
AU606778B2 (en) | 1991-02-14 |
NZ227853A (en) | 1990-06-26 |
IL89156A0 (en) | 1989-09-10 |
ATE95816T1 (de) | 1993-10-15 |
JPH0225481A (ja) | 1990-01-26 |
PT89643A (pt) | 1989-10-04 |
PT89643B (pt) | 1994-02-28 |
DK50089A (da) | 1990-01-13 |
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