KR900001676A - 2-[(4- 피페리디닐)메틸)-1,2,3,4-테트라히드로이소퀴놀린, 그의 제법 및 치료에의 이용 - Google Patents

2-[(4- 피페리디닐)메틸)-1,2,3,4-테트라히드로이소퀴놀린, 그의 제법 및 치료에의 이용 Download PDF

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Publication number
KR900001676A
KR900001676A KR1019890001304A KR890001304A KR900001676A KR 900001676 A KR900001676 A KR 900001676A KR 1019890001304 A KR1019890001304 A KR 1019890001304A KR 890001304 A KR890001304 A KR 890001304A KR 900001676 A KR900001676 A KR 900001676A
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South Korea
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formula
group
methyl
compound
branched
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KR1019890001304A
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English (en)
Inventor
조르지 파스칼
세브랑 미레이유
말로아젤 크리스티앙
틱시드르 알레뜨
프로아상 쟉끄
Original Assignee
에.뚜레 레메뜨르
신떼라보 소시에떼 아노님
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Priority claimed from FR8809447A external-priority patent/FR2634204B2/fr
Application filed by 에.뚜레 레메뜨르, 신떼라보 소시에떼 아노님 filed Critical 에.뚜레 레메뜨르
Publication of KR900001676A publication Critical patent/KR900001676A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

2-[(4-피페리디닐)메틸]-1,2,3,4-테트라히드로이소퀴놀린, 그의 제법 및 치료에의 이용
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 다음 일반식(I)의 화합물 및 그의 산부가염.
    상기식에서, X는 수소원자 또는 메틸 또는 메톡시기를 나타내며, Y는 할로겐원자 또는 메틸 또는 메톡시기를 나타내고, R은 일반식-Z-R′의 기를 나타내는데 여기서 Z는 -CH2-기 또는 -CO-기를 나타내며, R′는 할로겐원자 및 트리플루오로 메틸, 선형 또는 분기형(C1-C3)알킬, 그리고 선형 또는 분기형(C1-C3)알콕시기로 부터 선택된 1 내지 3개의 치환체를 임의적으로 지니는 페닐기를 나타낸다.
  2. 일반식(II)
    (상기식에서 X와 Y는 제 1 항에 정의된 것과 같다)의 1,2,3,4-테트라히드로 이소퀴놀린을 일반식(III)
    (상기식에서 Tos는 토실기를 나타내며 R′는 제 1 항에 정의된 것과 같다)의 토실레이트와, 디메틸포름아미드, 톨루엔, 또는 크실렌과 같은 비활성용매의 부재 또는 존재하에 20 내지 150℃의 온도에서 그리고 임의적으로 3차 아민과 같은 유기염기, 또는 알칼리금속 탄산염 또는 중탄산염과 같은 무기염기의 존재하에 반응시켜, 따라서,
    일반식(Ia)
    의 화합물을 걷은 다음, 만일 Z가 -CH3-기를 나타내는 일반식(I)의 화합물을 제조하는 것이 요구된다면, 일반식(Ia)의 화합물을 계속해서 수소화알루미늄리튬, 수소화알루미늄, 디보란/테트라히드로푸란 착체 또는 디보란/황화메틸착체와 같은 단순 또는 착체 수소화 붕소 또는 알루미늄으로 디에틸에테르, 테트라히드로푸란 또는 디옥산과 같은 에테르성용매에서 20 내지 100℃의 온도에서 환원시키는 것을 특징으로하는 제 1 항에 따르는 화합물의 제조방법.
  3. 약학적 부형제와 조합하여 제 1 항에 따르는 화합물을 함유하는 것을 특징으로 하는 약학조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890001304A 1988-07-12 1989-02-04 2-[(4- 피페리디닐)메틸)-1,2,3,4-테트라히드로이소퀴놀린, 그의 제법 및 치료에의 이용 KR900001676A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8809447A FR2634204B2 (fr) 1987-08-07 1988-07-12 Derives de ((piperidinyl-4)methyl)-2 tetrahydro-1,2,3,4 isoquinoleines, leur preparation et leur application en therapeutique
FR8809447 1988-07-12

Publications (1)

Publication Number Publication Date
KR900001676A true KR900001676A (ko) 1990-02-27

Family

ID=9368349

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890001304A KR900001676A (ko) 1988-07-12 1989-02-04 2-[(4- 피페리디닐)메틸)-1,2,3,4-테트라히드로이소퀴놀린, 그의 제법 및 치료에의 이용

Country Status (15)

Country Link
US (1) US4925850A (ko)
EP (1) EP0351255B1 (ko)
JP (1) JPH0225481A (ko)
KR (1) KR900001676A (ko)
AT (1) ATE95816T1 (ko)
AU (1) AU606778B2 (ko)
DE (1) DE68909855D1 (ko)
DK (1) DK50089A (ko)
FI (1) FI890520A (ko)
HU (1) HU201543B (ko)
IL (1) IL89156A (ko)
NO (1) NO171786C (ko)
NZ (1) NZ227853A (ko)
PT (1) PT89643B (ko)
ZA (1) ZA89905B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101042208B1 (ko) * 2008-09-26 2011-06-20 현대종합금속 주식회사 셀프 쉴디드(ｓｅｌｆ－ｓｈｉｅｌｄｅｄ) 아크 용접 플럭스 충전 와이어

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0306375A1 (fr) * 1987-08-07 1989-03-08 Synthelabo Dérivés de[(pipéridinyl-4)méthyl]-2 tétrahydro-1,2,3,4 isoquinoléine, leur préparation et leur application en thérapeutique
FR2661178B1 (fr) * 1990-04-24 1993-03-12 Synthelabo Derives de [(tetrahydro-1,2,3,4 isoquinoleinyl-2)methyl]-4 piperidinecarboxylates-1 d'alkyle, leur preparation et leur application en therapeutique.
US5132311A (en) * 1990-06-27 1992-07-21 G. D. Searle & Co. Cyanoquanidine type III antiarrhythmic agents and use
FR2747386B1 (fr) * 1996-04-12 1998-05-15 Synthelabo Derives de 3-[(1,2,3,4-tetrahydroisoquinolein-2-yl)methyl] -8-azabicyclo [3.2.1] octane, leur preparation et leur application en therapeutique
CA2263284A1 (en) * 1996-08-14 1998-02-19 Smithkline Beecham P.L.C. Tetrahydroisoquinoline derivatives and their pharmaceutical use
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
DE69929704T2 (de) 1998-10-08 2006-07-20 Smithkline Beecham Plc, Brentford Tetrahydrobenzazepin-derivate verwendbar als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel)
DE10060176B4 (de) 2000-12-04 2008-06-19 Precitec Kg Laserbearbeitungskopf
KR101804749B1 (ko) 2009-06-26 2017-12-05 사노피 히스타민 ｈ3 수용체 길항제의 신규 푸마레이트 염

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670041A1 (de) * 1967-03-14 1972-03-02 American Home Prod Isoindole und Isoindoline
FR7607M (ko) * 1968-04-25 1970-01-19
GB1250719A (ko) * 1969-03-19 1971-10-20
US3836536A (en) * 1972-06-08 1974-09-17 Warner Lambert Co 1,2,3,4-tetrahydro-3-aminomethyliso-quinolines
FR2426046A1 (fr) * 1978-05-18 1979-12-14 Synthelabo Derive de tetrahydro-isoquinoleine, sa preparation et son application en therapeutique
US4220778A (en) * 1978-10-30 1980-09-02 G. D. Searle & Co. 8-Aryl-1,2,3,4-tetrahydroisoquinoline and derivatives thereof
US4766131A (en) * 1980-10-17 1988-08-23 Pennwalt Corporation 2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0306375A1 (fr) * 1987-08-07 1989-03-08 Synthelabo Dérivés de[(pipéridinyl-4)méthyl]-2 tétrahydro-1,2,3,4 isoquinoléine, leur préparation et leur application en thérapeutique

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101042208B1 (ko) * 2008-09-26 2011-06-20 현대종합금속 주식회사 셀프 쉴디드(ｓｅｌｆ－ｓｈｉｅｌｄｅｄ) 아크 용접 플럭스 충전 와이어

Also Published As

Publication number Publication date
DE68909855D1 (de) 1993-11-18
EP0351255A3 (en) 1990-05-02
AU2961789A (en) 1990-01-18
NO890440D0 (no) 1989-02-03
HU201543B (en) 1990-11-28
NO890440L (no) 1990-01-15
FI890520A0 (fi) 1989-02-03
ZA89905B (en) 1989-10-25
FI890520A (fi) 1990-01-13
EP0351255A2 (fr) 1990-01-17
NO171786B (no) 1993-01-25
NO171786C (no) 1993-05-05
DK50089D0 (da) 1989-02-03
EP0351255B1 (fr) 1993-10-13
US4925850A (en) 1990-05-15
HUT50327A (en) 1990-01-29
IL89156A (en) 1993-05-13
AU606778B2 (en) 1991-02-14
NZ227853A (en) 1990-06-26
IL89156A0 (en) 1989-09-10
ATE95816T1 (de) 1993-10-15
JPH0225481A (ja) 1990-01-26
PT89643A (pt) 1989-10-04
PT89643B (pt) 1994-02-28
DK50089A (da) 1990-01-13

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