ES8203880A1 - Un procedimiento para preparar una 4,5-dihidro-2-r-4-r -6-py-3(2h)-piridazinona - Google Patents

Un procedimiento para preparar una 4,5-dihidro-2-r-4-r -6-py-3(2h)-piridazinona

Info

Publication number
ES8203880A1
ES8203880A1 ES501666A ES501666A ES8203880A1 ES 8203880 A1 ES8203880 A1 ES 8203880A1 ES 501666 A ES501666 A ES 501666A ES 501666 A ES501666 A ES 501666A ES 8203880 A1 ES8203880 A1 ES 8203880A1
Authority
ES
Spain
Prior art keywords
pyridazinones
pyridinyl
alkyl
dihydro
butanoate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES501666A
Other languages
English (en)
Other versions
ES501666A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/243,472 external-priority patent/US4337253A/en
Priority claimed from US06/245,086 external-priority patent/US4486431A/en
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ES501666A0 publication Critical patent/ES501666A0/es
Publication of ES8203880A1 publication Critical patent/ES8203880A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR UNA 4,5-DIHIDRO-2R-4-R''-6-PY-3(2H)-PIRIDA-ZINONA. CONSISTE EN HACER REACCIONAR UN 2-R''-4-OXO-4-PY-BUTANONITRILO, DE UN 2-R''-4-OXO-4-PY-BUTANOATO DE ALQUILO INFERIOR, O DE UN 2-R''-4-(BN)-4-CIANO-4-PY-BUTANOATO DEALQUILO INFERIOR, DONDE BN ES 4-MORFOLINILO, 1-PIPERIDINILO O 1-PIRROLIDINILO , CON N-R-HIDRACINA, CON UNA SAL DE ESTA FORMADA POR UN ACIDO INORGANICO CONCENTRADO O POR UN ACIDO SULFONICO, ORGANICO O INORGANICO, SE OBTIENE EL COMPUESTO DE FORMULA GENERAL (I), SIENDO PY 4- O 3-PIRIDINILO; R ES ALQUILO O HIDROXIALQUILO; R'' ES HIDROGENO O METILO.
ES501666A 1980-04-28 1981-04-27 Un procedimiento para preparar una 4,5-dihidro-2-r-4-r -6-py-3(2h)-piridazinona Expired ES8203880A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14456480A 1980-04-28 1980-04-28
US06/243,472 US4337253A (en) 1980-04-28 1981-03-13 4,5-Dihydro-2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone and its use as a cardiotonic
US06/245,086 US4486431A (en) 1981-01-14 1981-03-18 Cardiotonic use of 4,5-dihydro-6-(4-pyridinyl)-3(2H)-pyridazinones

Publications (2)

Publication Number Publication Date
ES501666A0 ES501666A0 (es) 1982-04-01
ES8203880A1 true ES8203880A1 (es) 1982-04-01

Family

ID=27386124

Family Applications (1)

Application Number Title Priority Date Filing Date
ES501666A Expired ES8203880A1 (es) 1980-04-28 1981-04-27 Un procedimiento para preparar una 4,5-dihidro-2-r-4-r -6-py-3(2h)-piridazinona

Country Status (15)

Country Link
AT (1) ATA190481A (es)
DE (1) DE3116791A1 (es)
DK (1) DK186781A (es)
ES (1) ES8203880A1 (es)
FR (1) FR2481282A1 (es)
GB (1) GB2076807B (es)
IL (1) IL62679A0 (es)
IT (1) IT1137465B (es)
LU (1) LU83320A1 (es)
NL (1) NL8102078A (es)
NO (1) NO811421L (es)
NZ (1) NZ196889A (es)
PH (1) PH16845A (es)
PT (1) PT72936B (es)
SE (1) SE8102661L (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4304777A (en) * 1979-08-30 1981-12-08 Sterling Drug Inc. 6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics

Also Published As

Publication number Publication date
ES501666A0 (es) 1982-04-01
NL8102078A (nl) 1981-11-16
DK186781A (da) 1981-10-29
LU83320A1 (fr) 1981-12-01
IT1137465B (it) 1986-09-10
NZ196889A (en) 1984-04-27
ATA190481A (de) 1983-12-15
NO811421L (no) 1981-10-29
GB2076807A (en) 1981-12-09
DE3116791A1 (de) 1982-04-15
IT8121384A0 (it) 1981-04-27
FR2481282A1 (fr) 1981-10-30
GB2076807B (en) 1984-03-14
PH16845A (en) 1984-03-19
IL62679A0 (en) 1981-06-29
PT72936A (en) 1981-05-01
PT72936B (en) 1982-04-12
SE8102661L (sv) 1981-10-29

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