KR830005202A - 4,5-디하이드로-6-(4-피리디닐)-3(2h) 피리다지논의 제조방법 - Google Patents
4,5-디하이드로-6-(4-피리디닐)-3(2h) 피리다지논의 제조방법 Download PDFInfo
- Publication number
- KR830005202A KR830005202A KR1019810001436A KR810001436A KR830005202A KR 830005202 A KR830005202 A KR 830005202A KR 1019810001436 A KR1019810001436 A KR 1019810001436A KR 810001436 A KR810001436 A KR 810001436A KR 830005202 A KR830005202 A KR 830005202A
- Authority
- KR
- South Korea
- Prior art keywords
- pyridinyl
- pyridazinone
- dihydro
- preparing
- lower alkyl
- Prior art date
Links
- FBOQGQULUAPQCC-UHFFFAOYSA-N 3-pyridin-4-yl-4,5-dihydro-1h-pyridazin-6-one Chemical compound N1C(=O)CCC(C=2C=CN=CC=2)=N1 FBOQGQULUAPQCC-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine Substances NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 구조식 I이나 그것의 부가산염을 가지고 있는 4,5-디하이드로-2-R-4-R'-6-PY-3(2H)-피리다지논을 제조하는 과정(여기서 PY는 하나 두개의 저급알킬 치환기를 가진 4 또는 3-피리디닐 또는 4 또는 3-피리디닐 R은 저급알킬 또는 저급하이드록시알킬 R'는 수소 혹은 메틸 그리고 R'가 메틸일때는 R은 수소일수 있다) 이것은 2-R'-4-옥소-4-PY-부탄니트릴 저급알킬 2-R'-4-옥소-4-PY-부탄에이트 또는 저급알킬 2-R'-4-(BN) 4-시아노-4-PY-부탄에이트(여기서 BN은 4-/.940홀러닐, 1-피페리디닐, 혹은 1-피로리디닐)를 N-R-히드라진이나 강한 무기산이나 유기황산의 염과 반응함으로써, 그리고 만일 요구될 경우 위에서 얻은 염기를 산부가염으로 변화시킴으로써 특징지어진다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14456480A | 1980-04-28 | 1980-04-28 | |
| US144564 | 1980-04-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830005202A true KR830005202A (ko) | 1983-08-03 |
Family
ID=22509146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810001436A KR830005202A (ko) | 1980-04-28 | 1981-04-27 | 4,5-디하이드로-6-(4-피리디닐)-3(2h) 피리다지논의 제조방법 |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS572284A (ko) |
| KR (1) | KR830005202A (ko) |
| AU (1) | AU6991781A (ko) |
| BE (1) | BE888567A (ko) |
| CA (1) | CA1166255A (ko) |
| ZA (1) | ZA812698B (ko) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5446042A (en) * | 1991-11-29 | 1995-08-29 | Zenyaku Kogyo Kabushiki Kaisha | Heterocyclic compound and cardiotonic agent containing the same as effective component |
-
1981
- 1981-04-24 ZA ZA00812698A patent/ZA812698B/xx unknown
- 1981-04-27 CA CA000376356A patent/CA1166255A/en not_active Expired
- 1981-04-27 KR KR1019810001436A patent/KR830005202A/ko unknown
- 1981-04-27 BE BE1/10210A patent/BE888567A/fr not_active IP Right Cessation
- 1981-04-28 JP JP6510481A patent/JPS572284A/ja active Pending
- 1981-04-28 AU AU69917/81A patent/AU6991781A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JPS572284A (en) | 1982-01-07 |
| CA1166255A (en) | 1984-04-24 |
| BE888567A (fr) | 1981-10-27 |
| ZA812698B (en) | 1982-04-28 |
| AU6991781A (en) | 1981-11-05 |
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