KR830003474A - 2-r-6-py-3(2h)-피리다지논이나 약제학적으로 가능한 그의 산부가염류의 제조방법 - Google Patents
2-r-6-py-3(2h)-피리다지논이나 약제학적으로 가능한 그의 산부가염류의 제조방법 Download PDFInfo
- Publication number
- KR830003474A KR830003474A KR1019800003375A KR800003375A KR830003474A KR 830003474 A KR830003474 A KR 830003474A KR 1019800003375 A KR1019800003375 A KR 1019800003375A KR 800003375 A KR800003375 A KR 800003375A KR 830003474 A KR830003474 A KR 830003474A
- Authority
- KR
- South Korea
- Prior art keywords
- pyridazinone
- preparing
- pharmaceutically acceptable
- addition salt
- acid addition
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 5
- 239000002253 acid Substances 0.000 title claims 2
- 150000003839 salts Chemical class 0.000 title claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- -1 4-pyridinyl Chemical group 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 상응하는 2-R-4,5-디하이드로-6-PY-3(2H)-피리다지논을 탈수소화제와 반응시켜 구조식(Ⅰ)의 2-R-6-PY-3(2H)-피리다지논이나 약제학적으로 가능한 그의 산부가염을 제조하는 방법.여기서 PY는 1-2의 저급알킬 치환체를 갖는 4- 또는 3-피리딘일 이고 R은 수소, 저급알킬 또는 저급하이드록시 알킬이다.
- PY가 4-피리딘일 또는 3-피리니닐임을 특징으로하는 청구범위 제1항에 기재된 방법.
- R이 수소, 메틸, 에틸 또는 하이드록시에틸임을 특징으로 하는 청구범위 제1항에 기재된 방법.
- 2-R-4,5-디하이드로-6-PY-3(2H)-피리다지논을 초산내에서 부롬과 함께 가열하므로서 반응이 수행됨을 특징으로하는 청구범위 제1-3항에 기재된 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7106579A | 1979-08-30 | 1979-08-30 | |
| US71065 | 1979-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830003474A true KR830003474A (ko) | 1983-06-20 |
Family
ID=22099030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019800003375A KR830003474A (ko) | 1979-08-30 | 1980-08-26 | 2-r-6-py-3(2h)-피리다지논이나 약제학적으로 가능한 그의 산부가염류의 제조방법 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5634678A (ko) |
| KR (1) | KR830003474A (ko) |
| BE (1) | BE884859A (ko) |
| ZA (1) | ZA805215B (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4404203A (en) | 1981-05-14 | 1983-09-13 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| US4397854A (en) | 1981-05-14 | 1983-08-09 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| JPS60132494U (ja) * | 1984-02-08 | 1985-09-04 | 堀庭 昌一 | 転写ししゆう布 |
-
1980
- 1980-08-21 BE BE1/9934A patent/BE884859A/fr not_active IP Right Cessation
- 1980-08-25 ZA ZA00805215A patent/ZA805215B/xx unknown
- 1980-08-25 JP JP11601380A patent/JPS5634678A/ja active Pending
- 1980-08-26 KR KR1019800003375A patent/KR830003474A/ko unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA805215B (en) | 1981-08-26 |
| BE884859A (fr) | 1981-02-23 |
| JPS5634678A (en) | 1981-04-06 |
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