KR840007409A - 복소환 또는 치환에 의해 6위치에 치환된 아미드화 피리다진 유도체의 제조방법 - Google Patents
복소환 또는 치환에 의해 6위치에 치환된 아미드화 피리다진 유도체의 제조방법 Download PDFInfo
- Publication number
- KR840007409A KR840007409A KR1019840000274A KR840000274A KR840007409A KR 840007409 A KR840007409 A KR 840007409A KR 1019840000274 A KR1019840000274 A KR 1019840000274A KR 840000274 A KR840000274 A KR 840000274A KR 840007409 A KR840007409 A KR 840007409A
- Authority
- KR
- South Korea
- Prior art keywords
- amine
- pyridazine
- chlorinated derivative
- thienyl
- methyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 4
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical group C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 title 1
- 238000006467 substitution reaction Methods 0.000 title 1
- 150000001412 amines Chemical class 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- RWIVICVCHVMHMU-UHFFFAOYSA-N n-aminoethylmorpholine Chemical group NCCN1CCOCC1 RWIVICVCHVMHMU-UHFFFAOYSA-N 0.000 claims 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- 150000002576 ketones Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical compound OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 claims 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- VPNGLLJBAXZKOA-UHFFFAOYSA-N 3-chloro-4-methyl-6-thiophen-2-ylpyridazine Chemical group N1=C(Cl)C(C)=CC(C=2SC=CC=2)=N1 VPNGLLJBAXZKOA-UHFFFAOYSA-N 0.000 claims 1
- CMMUAXBNDNEYSF-UHFFFAOYSA-N 3-chloro-4-methyl-6-thiophen-3-ylpyridazine Chemical group N1=C(Cl)C(C)=CC(C2=CSC=C2)=N1 CMMUAXBNDNEYSF-UHFFFAOYSA-N 0.000 claims 1
- CDIUCMHYJHHARI-UHFFFAOYSA-N 3-chloro-6-cyclohexyl-4-methylpyridazine Chemical group N1=C(Cl)C(C)=CC(C2CCCCC2)=N1 CDIUCMHYJHHARI-UHFFFAOYSA-N 0.000 claims 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000004716 alpha keto acids Chemical class 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- RCJVRSBWZCNNQT-UHFFFAOYSA-N dichloridooxygen Chemical compound ClOCl RCJVRSBWZCNNQT-UHFFFAOYSA-N 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000004892 pyridazines Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 하기 일반식1의 염소화 유도체를 알콜과 같은 용매에서 수소산수용체 존재하고 온에서 하기 일반식2의 아민과 반응시키고, 필요하다면 수득된 유도체를 약학적으로 수용할 수 있는 염으로 전환시킴을 특징으로 하는 하기 일반식(I)의 아미드화 피리다진 유도체 및 그의 산부가염의 제조방법.
-
- (상기식중, R1은 2-티에닐, 3-티에닐 또는 시클로헥실기를 나타내고, R2는 저급 알킬기(1~4탄소원자) 또는 수소원자를 나타낸다.)
- 제1항에 있어서, 염소화 유도체가 케톤 R1-CO-CH3와 α-케토산 R2-CO-COOH를 축합하고, 수득된 α-히드록시 감마 케톤산을 히드라진 NH2-NH2와 반응시켜 상응하는 3-피리다존을 수득한 후, 이를 포스포리스 옥시클로라이드와 반응시킴으로써 수득됨을 특징으로 하는 방법.
- 제1항에 있어서, 염소화 유도체가 3클로로 4-메틸 6-(2-티에닐)피리다진이고 아민이 2-모르폴리노에틸아민인 방법.
- 제1항에 있어서, 염소화 유도체가 3-클로로 4-메틸 6-(3-티에닐) 피리다진이고 아민이 2-모르폴리노에틸 아민인 방법.
- 제1항에 있어서, 염소화 유도체가 3-클로로 4-메틸 6-시클로헥실 피리다진이고 아민이 2-모르폴리노에틸 아민인 방법.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8301029 | 1983-01-24 | ||
FR8301029A FR2539742B1 (fr) | 1983-01-24 | 1983-01-24 | Derives amines de la pyridazine substitues en position 6 par un heterocycle ou un alicycle, lesdits derives etant actifs sur le systeme nerveux central |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840007409A true KR840007409A (ko) | 1984-12-07 |
KR910000641B1 KR910000641B1 (ko) | 1991-01-31 |
Family
ID=9285222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840000274A KR910000641B1 (ko) | 1983-01-24 | 1984-01-23 | 복소환 또는 치환에 의해 6위치에 치환된 아미노화 피리다진 유도체의 제조방법 |
Country Status (24)
Country | Link |
---|---|
US (1) | US4524070A (ko) |
EP (1) | EP0117171B1 (ko) |
JP (1) | JPS59139367A (ko) |
KR (1) | KR910000641B1 (ko) |
AT (1) | ATE28077T1 (ko) |
AU (1) | AU560542B2 (ko) |
CA (1) | CA1218063A (ko) |
CS (1) | CS241539B2 (ko) |
DD (1) | DD238793A5 (ko) |
DE (1) | DE3464491D1 (ko) |
DK (1) | DK31584A (ko) |
ES (1) | ES529007A0 (ko) |
FI (1) | FI840268A (ko) |
FR (1) | FR2539742B1 (ko) |
GR (1) | GR81717B (ko) |
HU (1) | HU192390B (ko) |
IE (1) | IE840150L (ko) |
IL (1) | IL70757A (ko) |
NO (1) | NO840244L (ko) |
NZ (1) | NZ206907A (ko) |
PT (1) | PT77982B (ko) |
SU (1) | SU1189345A3 (ko) |
YU (1) | YU12384A (ko) |
ZA (1) | ZA84501B (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2269788A (en) * | 1987-08-19 | 1989-03-09 | Erich-Klaus Martin | Process for purifying and regenerating used oils |
PT93060B (pt) | 1989-02-07 | 1995-12-29 | Sanofi Sa | Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem |
US5656631A (en) * | 1989-02-07 | 1997-08-12 | Sanofi | Pyridazine derivatives |
FR2665442B1 (fr) * | 1990-07-31 | 1992-12-04 | Sanofi Sa | Derives d'alkyl-6 pyridazine, procede de preparation et compositions pharmaceutiques en contenant. |
US5461053A (en) * | 1989-02-07 | 1995-10-24 | Sanofi | Pyridazine derivatives |
AU2005260102A1 (en) * | 2004-05-08 | 2006-01-12 | Novartis International Pharmaceutical Ltd. | 3-aryl-5,6-disubstituted pyridazines |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1292443A (en) * | 1968-11-01 | 1972-10-11 | Ct D Etudes Experimentales Et | New pyridazine derivatives and process for their preparation |
GB1345880A (en) * | 1971-06-18 | 1974-02-06 | Cepbepe | Pyridazine derivatives |
-
1983
- 1983-01-24 FR FR8301029A patent/FR2539742B1/fr not_active Expired
-
1984
- 1984-01-18 DE DE8484400102T patent/DE3464491D1/de not_active Expired
- 1984-01-18 CA CA000445483A patent/CA1218063A/en not_active Expired
- 1984-01-18 US US06/571,698 patent/US4524070A/en not_active Expired - Fee Related
- 1984-01-18 EP EP84400102A patent/EP0117171B1/fr not_active Expired
- 1984-01-18 AT AT84400102T patent/ATE28077T1/de active
- 1984-01-19 ES ES529007A patent/ES529007A0/es active Granted
- 1984-01-20 PT PT77982A patent/PT77982B/pt not_active IP Right Cessation
- 1984-01-20 NZ NZ206907A patent/NZ206907A/en unknown
- 1984-01-23 ZA ZA84501A patent/ZA84501B/xx unknown
- 1984-01-23 GR GR73585A patent/GR81717B/el unknown
- 1984-01-23 SU SU843694357A patent/SU1189345A3/ru active
- 1984-01-23 KR KR1019840000274A patent/KR910000641B1/ko active IP Right Grant
- 1984-01-23 FI FI840268A patent/FI840268A/fi not_active Application Discontinuation
- 1984-01-23 IL IL70757A patent/IL70757A/xx unknown
- 1984-01-23 NO NO840244A patent/NO840244L/no unknown
- 1984-01-23 DD DD84259545A patent/DD238793A5/de unknown
- 1984-01-23 IE IE840150A patent/IE840150L/xx unknown
- 1984-01-24 CS CS84530A patent/CS241539B2/cs unknown
- 1984-01-24 AU AU23727/84A patent/AU560542B2/en not_active Ceased
- 1984-01-24 JP JP59010903A patent/JPS59139367A/ja active Pending
- 1984-01-24 YU YU00123/84A patent/YU12384A/xx unknown
- 1984-01-24 DK DK31584A patent/DK31584A/da unknown
- 1984-01-24 HU HU84294A patent/HU192390B/hu unknown
Also Published As
Publication number | Publication date |
---|---|
ES8407043A1 (es) | 1984-09-01 |
PT77982A (fr) | 1984-02-01 |
HU192390B (en) | 1987-06-29 |
FR2539742A1 (fr) | 1984-07-27 |
AU2372784A (en) | 1984-07-26 |
US4524070A (en) | 1985-06-18 |
GR81717B (ko) | 1984-12-12 |
NZ206907A (en) | 1987-03-31 |
KR910000641B1 (ko) | 1991-01-31 |
DK31584A (da) | 1984-07-25 |
DE3464491D1 (en) | 1987-08-06 |
IL70757A0 (en) | 1984-04-30 |
CS53084A2 (en) | 1985-07-16 |
DK31584D0 (da) | 1984-01-24 |
SU1189345A3 (ru) | 1985-10-30 |
ZA84501B (en) | 1984-09-26 |
IE840150L (en) | 1984-07-24 |
ES529007A0 (es) | 1984-09-01 |
PT77982B (fr) | 1986-04-10 |
DD238793A5 (de) | 1986-09-03 |
ATE28077T1 (de) | 1987-07-15 |
FR2539742B1 (fr) | 1986-09-05 |
YU12384A (en) | 1986-10-31 |
EP0117171A1 (fr) | 1984-08-29 |
CS241539B2 (en) | 1986-03-13 |
FI840268A0 (fi) | 1984-01-23 |
AU560542B2 (en) | 1987-04-09 |
FI840268A (fi) | 1984-07-25 |
JPS59139367A (ja) | 1984-08-10 |
NO840244L (no) | 1984-07-25 |
CA1218063A (en) | 1987-02-17 |
EP0117171B1 (fr) | 1987-07-01 |
IL70757A (en) | 1986-12-31 |
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