KR830007631A - 2-피리딘카복스아미드 유도체 및 이들의 제조방법 - Google Patents
2-피리딘카복스아미드 유도체 및 이들의 제조방법 Download PDFInfo
- Publication number
- KR830007631A KR830007631A KR1019810004735A KR810004735A KR830007631A KR 830007631 A KR830007631 A KR 830007631A KR 1019810004735 A KR1019810004735 A KR 1019810004735A KR 810004735 A KR810004735 A KR 810004735A KR 830007631 A KR830007631 A KR 830007631A
- Authority
- KR
- South Korea
- Prior art keywords
- general formula
- lower alkyl
- toxic salts
- pyridinecarboxamide
- formula
- Prior art date
Links
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical class NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 title claims 4
- 238000002360 preparation method Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims 4
- 231100000331 toxic Toxicity 0.000 claims 4
- 230000002588 toxic effect Effects 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- ULRPISSMEBPJLN-UHFFFAOYSA-N 2h-tetrazol-5-amine Chemical compound NC1=NN=NN1 ULRPISSMEBPJLN-UHFFFAOYSA-N 0.000 claims 2
- SIOXPEMLGUPBBT-UHFFFAOYSA-N Picolinic acid Natural products OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- VXKWYPOMXBVZSJ-UHFFFAOYSA-N tetramethyltin Chemical compound C[Sn](C)(C)C VXKWYPOMXBVZSJ-UHFFFAOYSA-N 0.000 claims 2
- 229940126062 Compound A Drugs 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- -1 phenoxy Phenyl Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (2)
- 하기 일반식(II)의 2-피리딘카복실산 또는 이의 반응성 유도체를 5-아미노테트라졸로 축합시키며, 필요한 경우 이 생성물을 약학적으로 무독한 이의 염으로 더욱 전환시킴을 특징으로 하는 하기 일반식(I)의 2-피리딘 카복스아미드 유도체 또는 약학적으로 무독한 이의 염을 제조하는 방법.상기식에서, R1은 수소, 저급알킬, 저급알콕시, 할로겐, 저급알킬티오 또는 니트로이며, 피리딜그룹의 3-, 4- 5-위치에 존재하며 R2은 수소, 저급알킬, 저급알콕시, 페녹시, 페닐 저급알킬, 페닐저급알케닐 또는 할로겐을 나타낸다.
- 하기 일반식(II')의 2-피리딘카복실산 또는 이의 반응성 유도체를 5-아미노테트라졸로 축합시켜 하기 일반식(I')의 2-피리딘카복스아미드 유도체를 수득한 다음 이 생성화합물을 촉매수소화 시키며, 필요한 경우 이 생성물을 약학적으로 무독한 이의 염으로 전환시킴을 특징으로 하여, 하기 일반식(I)의 2-피리딘카복스아미드 유도체 또는 이의 약학적으로 무독한 이의 염을 제조하는 방법.※참고사항:최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55172246A JPS5795984A (en) | 1980-12-05 | 1980-12-05 | Pyridinecarboxamide derivative and its preparation |
JP55-172246 | 1980-12-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830007631A true KR830007631A (ko) | 1983-11-04 |
KR860000104B1 KR860000104B1 (ko) | 1986-02-19 |
Family
ID=15938324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019810004735A KR860000104B1 (ko) | 1980-12-05 | 1981-12-04 | 2-피리딘 카복스아미드 유도체의 제조방법 |
Country Status (7)
Country | Link |
---|---|
US (1) | US4404214A (ko) |
EP (1) | EP0053789B1 (ko) |
JP (1) | JPS5795984A (ko) |
KR (1) | KR860000104B1 (ko) |
CA (1) | CA1173444A (ko) |
DE (1) | DE3169602D1 (ko) |
ES (1) | ES507755A0 (ko) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4526979A (en) * | 1983-07-22 | 1985-07-02 | Merrell Dow Pharmaceuticals Inc. | Carbamates and oxalamides of amino-N-(1H-tetrazol-5-yl)benzamides |
US4792547A (en) * | 1985-12-26 | 1988-12-20 | Hokuriku Pharmaceutical Co., Ltd. | Pyrazine-2-carboxamide derivatives useful in treating allergic disease |
US4868193A (en) * | 1986-09-24 | 1989-09-19 | Rorer Pharmaceutical Corporation | Styryl tetrazoles and anti-allergic use thereof |
GB9005965D0 (en) * | 1990-03-16 | 1990-05-09 | Shell Int Research | Herbicidal carboxamide derivatives |
JPH08337770A (ja) * | 1995-06-09 | 1996-12-24 | Toyo Kasei Kogyo Co Ltd | テトラゾ−ル系ガス発生剤 |
FR2803592A1 (fr) * | 2000-01-06 | 2001-07-13 | Aventis Cropscience Sa | Nouveaux derives de l'acide 3-hydroxypicolinique, leur procede de preparation et compositions fongicides les contenant. |
CN100378094C (zh) * | 2003-02-13 | 2008-04-02 | 万有制药株式会社 | 2-吡啶甲酰胺衍生物 |
NZ540791A (en) | 2003-02-13 | 2009-09-25 | Banyu Pharma Co Ltd | Novel 2-pyridinecarboxamide derivatives |
JP2010138073A (ja) * | 2007-03-30 | 2010-06-24 | Taisho Pharmaceutical Co Ltd | ピコリン酸アミド化合物 |
EP2344458A1 (en) | 2008-09-11 | 2011-07-20 | Pfizer Inc. | Heteroaryls amide derivatives and their use as glucokinase activators |
EA018894B1 (ru) * | 2009-03-11 | 2013-11-29 | Пфайзер Инк. | N,n-диметил-5-(2-метил-6-((5-метилпиразин-2-ил)карбамоил)бензо-фуран-4-илокси)пиримидин-2-карбоксамид, используемый в качестве активатора глюкокиназы, и содержащая его фармацев-тическая композиция |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1561350A (en) * | 1976-11-05 | 1980-02-20 | May & Baker Ltd | Benzamide derivatives |
US4013647A (en) * | 1976-03-23 | 1977-03-22 | American Home Products Corporation | Morpholine containing tetrazole-5-carboxamide derivatives |
JPS5572188A (en) * | 1978-11-27 | 1980-05-30 | Kowa Co | 1,3,4-thiadiazole derivative and its preparation |
JPS56115784A (en) * | 1980-02-15 | 1981-09-11 | Tanabe Seiyaku Co Ltd | Novel pyridinecarboxamide derivative and its preparation |
-
1980
- 1980-12-05 JP JP55172246A patent/JPS5795984A/ja active Granted
-
1981
- 1981-11-20 US US06/323,289 patent/US4404214A/en not_active Expired - Fee Related
- 1981-12-01 DE DE8181110050T patent/DE3169602D1/de not_active Expired
- 1981-12-01 EP EP81110050A patent/EP0053789B1/en not_active Expired
- 1981-12-04 ES ES507755A patent/ES507755A0/es active Granted
- 1981-12-04 KR KR1019810004735A patent/KR860000104B1/ko active
- 1981-12-07 CA CA000391618A patent/CA1173444A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS6330909B2 (ko) | 1988-06-21 |
US4404214A (en) | 1983-09-13 |
EP0053789B1 (en) | 1985-03-27 |
DE3169602D1 (en) | 1985-05-02 |
KR860000104B1 (ko) | 1986-02-19 |
ES8303398A1 (es) | 1983-02-01 |
JPS5795984A (en) | 1982-06-15 |
ES507755A0 (es) | 1983-02-01 |
CA1173444A (en) | 1984-08-28 |
EP0053789A1 (en) | 1982-06-16 |
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