ES8202339A1 - Un procedimiento para preparar una pirazolopiridina - Google Patents

Un procedimiento para preparar una pirazolopiridina

Info

Publication number
ES8202339A1
ES8202339A1 ES500412A ES500412A ES8202339A1 ES 8202339 A1 ES8202339 A1 ES 8202339A1 ES 500412 A ES500412 A ES 500412A ES 500412 A ES500412 A ES 500412A ES 8202339 A1 ES8202339 A1 ES 8202339A1
Authority
ES
Spain
Prior art keywords
pyridinyl
cardiotonics
pyrazolo
amines
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500412A
Other languages
English (en)
Other versions
ES500412A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ES500412A0 publication Critical patent/ES500412A0/es
Publication of ES8202339A1 publication Critical patent/ES8202339A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UNA PIRAZOLIPIRIDINA DE FORMULA (I) Y DE SUS SALES DE ADICION DE ACIDO, EN LA QUE Q ES HIDROGENO O ALQUILO INFERIOR; PY ES 4 O 3-PIRIDINILO SIN SUSTITUIR O SUSTITUIDO CON UNO O DOS RADICALES ALQUILO INFERIOR; Y R PUEDER SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN 2-HALO-5-PY-6-Q-NICOTINONITRILO CON 1-R-HIDRAZINA, EN LAS QUE Q, PY Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), Y HALO ES CLORO O BROMO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, A UNA TEMPERATURA COMPREDNIDA ENTRE 50 Y 100 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES CARDIOTONICOS.
ES500412A 1980-03-17 1981-03-16 Un procedimiento para preparar una pirazolopiridina Expired ES8202339A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/131,227 US4264603A (en) 1980-03-17 1980-03-17 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation

Publications (2)

Publication Number Publication Date
ES500412A0 ES500412A0 (es) 1982-01-16
ES8202339A1 true ES8202339A1 (es) 1982-01-16

Family

ID=22448499

Family Applications (1)

Application Number Title Priority Date Filing Date
ES500412A Expired ES8202339A1 (es) 1980-03-17 1981-03-16 Un procedimiento para preparar una pirazolopiridina

Country Status (19)

Country Link
US (1) US4264603A (es)
JP (1) JPS56142281A (es)
KR (1) KR830005214A (es)
AU (1) AU6826081A (es)
BE (1) BE887890A (es)
DE (1) DE3109768A1 (es)
DK (1) DK114381A (es)
ES (1) ES8202339A1 (es)
FI (1) FI810759L (es)
FR (1) FR2478100A1 (es)
GB (1) GB2071660A (es)
IL (1) IL62295A0 (es)
IT (1) IT1141998B (es)
LU (1) LU83214A1 (es)
NL (1) NL8101217A (es)
NO (1) NO810834L (es)
PT (1) PT72654B (es)
SE (1) SE8101591L (es)
ZA (1) ZA811418B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361568A (en) * 1981-04-28 1982-11-30 Sterling Drug Inc. 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use
US4374141A (en) * 1981-08-17 1983-02-15 Sterling Drug Inc. 2-Substituted amino-5-(pyridinyl)-nicotinamides and their cardiotonic use
EP0200024B1 (de) 1985-04-30 1992-07-01 ARZNEIMITTELWERK DRESDEN GmbH 3-Cyan-pyridine, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
DD298781A5 (de) * 1990-03-09 1992-03-12 Inst Wirkstofforschung Verfahren zur herstellung von 5,4'-bipyridin-1'-oxiden
RS51768B (sr) * 2003-02-27 2011-12-31 Palau Pharma S.A. Derivati pirazolpiridina
US20090008238A1 (en) * 2004-04-09 2009-01-08 The Arizona Bd Of Reg On Behalf Of The Univ Of Az Transportable gas sterilization unit, disposable gas generator, light activated anti-infective coating and method of disinfection and sterilization using chlorine dioxide
TW200618800A (en) * 2004-08-03 2006-06-16 Uriach Y Compania S A J Heterocyclic compounds
CN102558044A (zh) * 2011-12-29 2012-07-11 方晏燕 米力农的结晶方法
CN103664773A (zh) * 2013-12-18 2014-03-26 南京易亨制药有限公司 米力农的制备方法和精制方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3423414A (en) * 1966-01-13 1969-01-21 Ciba Geigy Corp Pyrazolopyridines
DE2160780A1 (de) * 1971-12-08 1973-06-14 Basf Ag Pyridino-pyrazole
DE2232038A1 (de) * 1972-06-30 1974-01-10 Hoechst Ag 3-amino-1h-pyrazolo eckige klammer auf 3,4-b eckige klammer zu pyridine, ihre herstellung und verwendung
US4004012A (en) * 1975-10-14 1977-01-18 Sterling Drug Inc. 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones
US4072746A (en) * 1975-10-14 1978-02-07 Sterling Drug Inc. 3-Amino-5-(pyridinyl)-2(1H)-pyridinones
US4020072A (en) * 1976-05-04 1977-04-26 E. R. Squibb & Sons, Inc. 5-Aminomethyl-1H-pyrazolo[3,4-b]pyridines

Also Published As

Publication number Publication date
ES500412A0 (es) 1982-01-16
FI810759L (fi) 1981-09-18
PT72654A (en) 1981-04-01
JPS56142281A (en) 1981-11-06
IT1141998B (it) 1986-10-08
GB2071660A (en) 1981-09-23
DK114381A (da) 1981-09-18
DE3109768A1 (de) 1981-12-24
IT8120271A0 (it) 1981-03-10
NO810834L (no) 1981-09-18
PT72654B (en) 1982-03-19
US4264603A (en) 1981-04-28
SE8101591L (sv) 1981-09-18
FR2478100A1 (fr) 1981-09-18
KR830005214A (ko) 1983-08-03
AU6826081A (en) 1981-09-24
IL62295A0 (en) 1981-05-20
LU83214A1 (fr) 1981-10-30
NL8101217A (nl) 1981-10-16
BE887890A (fr) 1981-09-11
ZA811418B (en) 1982-03-31

Similar Documents

Publication Publication Date Title
SE8101951L (sv) Imidazopyridiner
ES8202816A1 (es) Un procedimiento para preparar diaminopiridinas
IE790676L (en) N-heterocyclyl-4-piperidinamines
IE810108L (en) IMIDAZO £1,2-a| PYRIDINES
PH22999A (en) 3-cyano-5-(6-imidazo(1,2-a)pyridyl)-pyridin-2-ols useful as cardiotonics
EP0040639A4 (en) ISOXAZOLE DERIVATIVES.
ES8301920A1 (es) Un procedimiento para preparar un derivado de piridina .
ES446388A1 (es) Procedimiento para preparar n-halo sustituido-2-pirrolido- nas.
ES453947A1 (es) Un procedimiento para la preparacion de nuevas imidazo (1,2-alfa) piridinas sustituidas.
ES8107215A1 (es) Un procedimiento para preparar una 2-r-6-py-3(2h)-piridaci- nona
ES8202339A1 (es) Un procedimiento para preparar una pirazolopiridina
ES477755A1 (es) Procedimiento para preparar derivados parcialmente clorados de 3-metil-piridina.
ES482700A1 (es) Procedimiento para la obtencion de alfa-azolil-beta-hidroxi-cetonas.
IE43519L (en) Benzimidazole-2-carbamates
ES468462A1 (es) Ÿun procedimiento para la preparacion de nuevos derivados depiridinaÿ
SE8107551L (sv) 1,2-dihydro-5-(pyridinyl)nikotinamidderivat och forfarande for framstellning derav
ES468127A1 (es) Un procedimiento para la preparacion de nuevos derivados de pirido (2,1-b) quinazolina
ES483484A1 (es) Procedimiento para la produccion de compuestos de n-feneti- lacetamida
ES8405777A1 (es) Procedimiento de preparacion de nuevas 2-amino 5-aminometil 2-oxazolinas
EP0031388A4 (en) METHOD FOR PRODUCING IMIDAZOLE DERIVATIVES.
IE780982L (en) 4-hydroxythiazoline-2-thiones.
ES8506301A1 (es) Un procedimiento para preparar 2-alcoxi-5-(piridinil) piridinas
IL65664A (en) 5-(4-phenyl-1-piperidinyl)methyl-2,3-dihydro-2-oxo-1h-imidazole-4-carboxylic acid derivatives and process for their preparation
ES8304568A1 (es) Un procedimiento para la preparacion de una 5-py-benzoxazol-2(3h) ona.
SE8107021L (sv) Nytt forfarande for framstellning av imidazo(4,5-b)-pyridiner och -pyrimidiner