ES8304568A1 - Un procedimiento para la preparacion de una 5-py-benzoxazol-2(3h) ona. - Google Patents
Un procedimiento para la preparacion de una 5-py-benzoxazol-2(3h) ona.Info
- Publication number
- ES8304568A1 ES8304568A1 ES507383A ES507383A ES8304568A1 ES 8304568 A1 ES8304568 A1 ES 8304568A1 ES 507383 A ES507383 A ES 507383A ES 507383 A ES507383 A ES 507383A ES 8304568 A1 ES8304568 A1 ES 8304568A1
- Authority
- ES
- Spain
- Prior art keywords
- benzoxazol
- pyridinyl
- ones
- cardiotonics
- cardiac contractility
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000496 cardiotonic agent Substances 0.000 title abstract 2
- 230000003177 cardiotonic effect Effects 0.000 title abstract 2
- SYOMERCVWJENPL-UHFFFAOYSA-N 5-pyridin-2-yl-3h-1,3-benzoxazol-2-one Chemical class C=1C=C2OC(=O)NC2=CC=1C1=CC=CC=N1 SYOMERCVWJENPL-UHFFFAOYSA-N 0.000 title 1
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 abstract 2
- 230000000747 cardiac effect Effects 0.000 abstract 2
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 5-PY-BENZOXAZOL-2-(3H)-ONAS Y DE SUS SALES CATIONICAS O DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE PY ES 4- O 3-PIRIDINILO SIN SUSTITUIR O SUSTITUIDO POR UNO O DOS ALQUILO INFERIOR. CONSISTE EN LA REACCION DE UN 2-AMINO-4-PY-FENOL CON UN AGENTE CARBONILANTE TAL COMO CARBONILDIIMIDAZOL. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE APROTICO INERTE, A UNA TEMPERATURA ENTRE LA AMBIENTE Y 100 C. EL COMPUESTO OBTENIDO SE PUEDE CONVERTIR EN UNA SAL CATIONICA O EN UNA SAL DE ADICION DE ACIDO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO CARDIOTONICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/209,416 US4310531A (en) | 1980-11-24 | 1980-11-24 | 5-(Pyridinyl)-benzoxazol-2(3H)-ones and their use as cardiotonics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES507383A0 ES507383A0 (es) | 1983-03-01 |
| ES8304568A1 true ES8304568A1 (es) | 1983-03-01 |
Family
ID=22778673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES507383A Expired ES8304568A1 (es) | 1980-11-24 | 1981-11-23 | Un procedimiento para la preparacion de una 5-py-benzoxazol-2(3h) ona. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4310531A (es) |
| JP (1) | JPS57116068A (es) |
| KR (1) | KR830007637A (es) |
| AR (1) | AR231139A1 (es) |
| AT (1) | AT379808B (es) |
| AU (1) | AU545707B2 (es) |
| BE (1) | BE891017A (es) |
| CA (1) | CA1159835A (es) |
| CH (1) | CH652124A5 (es) |
| DE (1) | DE3145847A1 (es) |
| DK (1) | DK510881A (es) |
| ES (1) | ES8304568A1 (es) |
| FI (1) | FI813550L (es) |
| FR (1) | FR2494690A1 (es) |
| GB (1) | GB2098594B (es) |
| GR (1) | GR78020B (es) |
| IL (1) | IL64129A (es) |
| IT (1) | IT1144937B (es) |
| LU (1) | LU83770A1 (es) |
| NL (1) | NL8105204A (es) |
| NO (1) | NO813911L (es) |
| NZ (1) | NZ198819A (es) |
| PH (1) | PH17977A (es) |
| PT (1) | PT73986B (es) |
| SE (1) | SE8106871L (es) |
| ZA (1) | ZA817487B (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1183046A (en) * | 1966-06-28 | 1970-03-04 | Allen & Hanburys Ltd | Novel Heterocyclic Compounds |
| CH532077A (de) * | 1968-05-31 | 1972-12-31 | Robapharm A G | Verfahren zur Herstellung von neuen basischen Derivaten des Benzoxazolin-2-ons |
-
1980
- 1980-11-24 US US06/209,416 patent/US4310531A/en not_active Expired - Lifetime
-
1981
- 1981-10-26 GB GB8132204A patent/GB2098594B/en not_active Expired
- 1981-10-27 IL IL64129A patent/IL64129A/xx unknown
- 1981-10-29 ZA ZA817487A patent/ZA817487B/xx unknown
- 1981-10-30 NZ NZ198819A patent/NZ198819A/en unknown
- 1981-11-03 PH PH26434A patent/PH17977A/en unknown
- 1981-11-05 FR FR8120745A patent/FR2494690A1/fr active Granted
- 1981-11-06 BE BE1/10350A patent/BE891017A/fr not_active IP Right Cessation
- 1981-11-10 FI FI813550A patent/FI813550L/fi not_active Application Discontinuation
- 1981-11-12 AU AU77417/81A patent/AU545707B2/en not_active Expired - Fee Related
- 1981-11-13 PT PT73986A patent/PT73986B/pt unknown
- 1981-11-16 GR GR66541A patent/GR78020B/el unknown
- 1981-11-17 KR KR1019810004439A patent/KR830007637A/ko unknown
- 1981-11-17 CH CH7393/81A patent/CH652124A5/fr not_active IP Right Cessation
- 1981-11-17 NL NL8105204A patent/NL8105204A/nl not_active Application Discontinuation
- 1981-11-17 IT IT25143/81A patent/IT1144937B/it active
- 1981-11-18 SE SE8106871A patent/SE8106871L/xx not_active Application Discontinuation
- 1981-11-18 DK DK510881A patent/DK510881A/da unknown
- 1981-11-18 NO NO813911A patent/NO813911L/no unknown
- 1981-11-19 AT AT0498981A patent/AT379808B/de not_active IP Right Cessation
- 1981-11-19 LU LU83770A patent/LU83770A1/fr unknown
- 1981-11-19 JP JP56186107A patent/JPS57116068A/ja active Pending
- 1981-11-19 DE DE19813145847 patent/DE3145847A1/de not_active Withdrawn
- 1981-11-19 AR AR287514A patent/AR231139A1/es active
- 1981-11-23 CA CA000390671A patent/CA1159835A/en not_active Expired
- 1981-11-23 ES ES507383A patent/ES8304568A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB2098594B (en) | 1984-08-22 |
| ZA817487B (en) | 1982-10-27 |
| PH17977A (en) | 1985-02-22 |
| IL64129A (en) | 1985-02-28 |
| PT73986B (en) | 1983-04-18 |
| DK510881A (da) | 1982-05-25 |
| IT8125143A0 (it) | 1981-11-17 |
| GR78020B (es) | 1984-09-26 |
| AU7741781A (en) | 1982-06-03 |
| FI813550L (fi) | 1982-05-25 |
| JPS57116068A (en) | 1982-07-19 |
| DE3145847A1 (de) | 1982-08-19 |
| FR2494690B1 (es) | 1985-05-17 |
| NO813911L (no) | 1982-05-25 |
| LU83770A1 (fr) | 1982-06-30 |
| KR830007637A (ko) | 1983-11-04 |
| US4310531A (en) | 1982-01-12 |
| AR231139A1 (es) | 1984-09-28 |
| CA1159835A (en) | 1984-01-03 |
| ATA498981A (de) | 1985-07-15 |
| SE8106871L (sv) | 1982-05-25 |
| ES507383A0 (es) | 1983-03-01 |
| NZ198819A (en) | 1984-07-06 |
| NL8105204A (nl) | 1982-06-16 |
| GB2098594A (en) | 1982-11-24 |
| FR2494690A1 (fr) | 1982-05-28 |
| IT1144937B (it) | 1986-10-29 |
| BE891017A (fr) | 1982-05-06 |
| CH652124A5 (fr) | 1985-10-31 |
| AU545707B2 (en) | 1985-07-25 |
| AT379808B (de) | 1986-03-10 |
| IL64129A0 (en) | 1982-01-31 |
| PT73986A (en) | 1981-12-01 |
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