ES8801655A1 - Un procedimiento para preparar derivados de piridina - Google Patents

Un procedimiento para preparar derivados de piridina

Info

Publication number
ES8801655A1
ES8801655A1 ES557588A ES557588A ES8801655A1 ES 8801655 A1 ES8801655 A1 ES 8801655A1 ES 557588 A ES557588 A ES 557588A ES 557588 A ES557588 A ES 557588A ES 8801655 A1 ES8801655 A1 ES 8801655A1
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
represents hydrogen
lower alkyl
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557588A
Other languages
English (en)
Other versions
ES557588A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of ES8801655A1 publication Critical patent/ES8801655A1/es
Publication of ES557588A0 publication Critical patent/ES557588A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIRIDINA, DE FORMULA (I). CONSISTE EN LA REACCION DE REDUCCION DE UN COMPUESTO DE FORMULA (II); SEGUIDA DE LA REACCION DE CONDENSACION DEL COMPUESTO DE FORMILO OBTENIDO CON NITROALCANO DE FORMULA O2NCH2W; Y, FINALMENTE, REDUCCION E HIDROLISIS DEL COMPUESTO OBTENIDO PARA FORMAR EL COMPUESTO DE FORMULA (I), EN LAS QUE W Y R9 REPRESENTAN HIDROGENO O ALQUILO INFERIOR, R2 ES HIDROGENO O HALOGENO Y R1 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD CARDIOTONICA.
ES557588A 1985-03-26 1987-06-15 Un procedimiento para preparar derivados de piridina Expired ES8801655A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60059450A JPS61218589A (ja) 1985-03-26 1985-03-26 ５―（６―イミダゾ〔１，２―ａ〕ピリジニル）ピリジン誘導体

Publications (2)

Publication Number Publication Date
ES8801655A1 true ES8801655A1 (es) 1988-02-16
ES557588A0 ES557588A0 (es) 1988-02-16

Family

ID=13113637

Family Applications (5)

Application Number Title Priority Date Filing Date
ES553370A Expired ES8706146A1 (es) 1985-03-26 1986-03-25 Un procedimiento para preparar derivados de piridina
ES557235A Expired ES8708230A1 (es) 1985-03-26 1986-12-01 Un procedimiento para preparar derivados de piridina
ES557236A Expired ES8708231A1 (es) 1985-03-26 1986-12-01 Un procedimiento para preparar derivados de piridina
ES557587A Expired ES8801654A1 (es) 1985-03-26 1987-06-15 Un procedimiento para preparar derivados de piridina
ES557588A Expired ES8801655A1 (es) 1985-03-26 1987-06-15 Un procedimiento para preparar derivados de piridina

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES553370A Expired ES8706146A1 (es) 1985-03-26 1986-03-25 Un procedimiento para preparar derivados de piridina
ES557235A Expired ES8708230A1 (es) 1985-03-26 1986-12-01 Un procedimiento para preparar derivados de piridina
ES557236A Expired ES8708231A1 (es) 1985-03-26 1986-12-01 Un procedimiento para preparar derivados de piridina
ES557587A Expired ES8801654A1 (es) 1985-03-26 1987-06-15 Un procedimiento para preparar derivados de piridina

Country Status (23)

Country Link
US (4) US4751227A (es)
EP (1) EP0199127B1 (es)
JP (1) JPS61218589A (es)
KR (1) KR930005005B1 (es)
CN (1) CN1020608C (es)
AT (1) ATE48603T1 (es)
AU (1) AU589410B2 (es)
CA (1) CA1309718C (es)
DD (2) DD283390A5 (es)
DE (1) DE3667466D1 (es)
DK (1) DK164788C (es)
ES (5) ES8706146A1 (es)
FI (1) FI86722C (es)
GR (1) GR860720B (es)
HU (1) HU198045B (es)
IE (1) IE59294B1 (es)
IL (1) IL78248A (es)
MX (1) MX163696B (es)
NO (1) NO163490C (es)
PH (1) PH22999A (es)
PT (1) PT82270B (es)
SU (1) SU1468420A3 (es)
ZA (1) ZA862259B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002941A (en) * 1985-12-12 1991-03-26 Smithkline Beecham Corporation Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
AU6355190A (en) * 1989-06-13 1991-01-17 Smithkline Beecham Corporation Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages
GB9008818D0 (en) * 1990-04-19 1990-06-13 Ici Plc Amine derivatives
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
SE9903611D0 (sv) * 1999-10-06 1999-10-06 Astra Ab Novel compounds III
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2518066B1 (en) * 2009-12-18 2016-05-18 Mitsubishi Tanabe Pharma Corporation Novel anti-platelet agent
CN101830900B (zh) * 2010-05-27 2012-06-06 齐鲁制药(海南)有限公司 盐酸奥普力农晶型及其制备方法
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9580471B2 (en) 2011-03-01 2017-02-28 Synergy Pharmaceuticals, Inc. Process of preparing guanylate cyclase C agonists
CN102718747B (zh) * 2012-06-27 2014-06-11 武汉武药科技有限公司 盐酸奥普力农衍生物及其合成方法
CN102702197B (zh) * 2012-06-27 2014-12-03 武汉武药科技有限公司 盐酸奥普力农衍生物及其制备方法
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス，インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
CN106349246B (zh) * 2016-08-29 2018-10-26 山东百诺医药股份有限公司 奥普力农及9-氮杂吲哚-5-硼酸的制备方法
CN108840866A (zh) * 2018-05-24 2018-11-20 河北宇辰医药科技有限公司 一种奥普力农类似物ⅰ的制备方法与用途
CN109575017A (zh) * 2018-11-01 2019-04-05 山东蒲济医药科技有限公司 一种盐酸奥普力农化合物的制备方法
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
CN111499631B (zh) * 2020-06-02 2021-07-30 济南康桥医药科技有限公司 一种盐酸奥普力农关键中间体1-咪唑并[1,2-a]吡啶-6-基-2-丙酮的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105767A (en) * 1977-03-28 1978-08-08 Merck & Co., Inc. Imidazo [1,2-a] pyridines substituted with a thienyl, thiazolyl, or thiadiazolyl group
ZA81219B (en) * 1980-01-23 1982-01-27 Schering Corp Imidazo (1,2-a) pyridines ,process for their preparation and pharmaceutical compositions containing them
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
DE3406329A1 (de) * 1984-02-22 1985-08-22 Merck Patent Gmbh, 6100 Darmstadt Pyridone

Also Published As

Publication number Publication date
US4751227A (en) 1988-06-14
IE860775L (en) 1986-09-26
IL78248A (en) 1989-09-10
ZA862259B (en) 1986-11-26
PT82270B (pt) 1988-02-17
JPH0558437B2 (es) 1993-08-26
US4803276A (en) 1989-02-07
CN1020608C (zh) 1993-05-12
KR860007257A (ko) 1986-10-10
ES557235A0 (es) 1987-10-01
DK164788C (da) 1992-12-28
FI86722C (fi) 1992-10-12
CN86102812A (zh) 1986-11-26
ATE48603T1 (de) 1989-12-15
ES557587A0 (es) 1988-02-16
JPS61218589A (ja) 1986-09-29
FI86722B (fi) 1992-06-30
IL78248A0 (en) 1986-07-31
ES8708231A1 (es) 1987-10-01
DK137786A (da) 1986-09-27
KR930005005B1 (ko) 1993-06-11
MX163696B (es) 1992-06-15
EP0199127B1 (en) 1989-12-13
ES8708230A1 (es) 1987-10-01
PH22999A (en) 1989-02-24
AU589410B2 (en) 1989-10-12
HUT41026A (en) 1987-03-30
DE3667466D1 (de) 1990-01-18
NO861190L (no) 1986-09-29
DK137786D0 (da) 1986-03-25
NO163490B (no) 1990-02-26
ES557236A0 (es) 1987-10-01
AU5507286A (en) 1986-10-02
SU1468420A3 (ru) 1989-03-23
FI861262A (fi) 1986-09-27
NO163490C (no) 1990-06-06
IE59294B1 (en) 1994-02-09
HU198045B (en) 1989-07-28
GR860720B (en) 1986-03-25
DK164788B (da) 1992-08-17
FI861262A0 (fi) 1986-03-25
ES8706146A1 (es) 1987-05-16
DD283390A5 (de) 1990-10-10
EP0199127A1 (en) 1986-10-29
ES553370A0 (es) 1987-05-16
CA1309718C (en) 1992-11-03
ES557588A0 (es) 1988-02-16
US4791202A (en) 1988-12-13
PT82270A (en) 1986-04-01
ES8801654A1 (es) 1988-02-16
DD263057A5 (de) 1988-12-21
US4791203A (en) 1988-12-13

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