ES8405777A1 - Procedimiento de preparacion de nuevas 2-amino 5-aminometil 2-oxazolinas - Google Patents

Procedimiento de preparacion de nuevas 2-amino 5-aminometil 2-oxazolinas

Info

Publication number
ES8405777A1
ES8405777A1 ES526275A ES526275A ES8405777A1 ES 8405777 A1 ES8405777 A1 ES 8405777A1 ES 526275 A ES526275 A ES 526275A ES 526275 A ES526275 A ES 526275A ES 8405777 A1 ES8405777 A1 ES 8405777A1
Authority
ES
Spain
Prior art keywords
amino
oxazolines
methyl
rings
less
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526275A
Other languages
English (en)
Other versions
ES526275A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cortial SA
Original Assignee
Cortial SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8216782A external-priority patent/FR2533922A1/fr
Priority claimed from FR8308477A external-priority patent/FR2546167B2/fr
Application filed by Cortial SA filed Critical Cortial SA
Publication of ES526275A0 publication Critical patent/ES526275A0/es
Publication of ES8405777A1 publication Critical patent/ES8405777A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 2-AMINO 5-AMINOMETIL-2-OXAZOLINAS DE FORMULA GENERAL (I), EN LA QUE R1 Y R2 REPRESENTAN UN RADICAL ALQUIL O ARILALQUIL.CONSISTE EN CONDENSAR EN UN DISOLVENTE TAL COMO EL METANOL, UN DERIVADO MONOSODICO DE LA CIANAMIDA SOBRE UN 1-AMINO 2,3-EPOXI PROPANO N-SUSTITUIDO, DE FORMULA GENERAL (II), EN LA QUE R1 Y R2 TIENEN EL SIGNIFICADO YA MENCIONADO.DE APLICACION EN TERAPEUTICA CARDIOVASCULAR, PSICOTROPA, ANTIINFLAMATORIA, ANTIALERGICA Y ANTIHISTAMINICA.
ES526275A 1982-10-05 1983-10-05 Procedimiento de preparacion de nuevas 2-amino 5-aminometil 2-oxazolinas Expired ES8405777A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8216782A FR2533922A1 (fr) 1982-10-05 1982-10-05 Nouvelles amino-2 aminomethyl-5 oxazolines-2, leur methode de preparation ainsi que leur application therapeutique
FR8308477A FR2546167B2 (fr) 1983-05-19 1983-05-19 Nouvelles amino-2 piperazino et piperidinomethyl-5 oxazolines-2, leur methode de preparation ainsi que leur application therapeutique

Publications (2)

Publication Number Publication Date
ES526275A0 ES526275A0 (es) 1984-06-16
ES8405777A1 true ES8405777A1 (es) 1984-06-16

Family

ID=26223093

Family Applications (1)

Application Number Title Priority Date Filing Date
ES526275A Expired ES8405777A1 (es) 1982-10-05 1983-10-05 Procedimiento de preparacion de nuevas 2-amino 5-aminometil 2-oxazolinas

Country Status (8)

Country Link
US (1) US4497812A (es)
EP (1) EP0106776B1 (es)
JP (1) JPH0647580B2 (es)
CA (1) CA1217485A (es)
DE (1) DE3367098D1 (es)
ES (1) ES8405777A1 (es)
OA (1) OA07555A (es)
PT (1) PT77428B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912120A (en) * 1986-03-14 1990-03-27 Syntex (U.S.A.) Inc. 3,5-substituted 4,5-dihydroisoxazoles as transglutaminase inhibitors
US4929630A (en) * 1986-03-14 1990-05-29 Syntex (U.S.A.) Inc. Transglutaminase inhibitors
FR2645860B1 (fr) * 1989-04-14 1991-07-26 Sarget Lab Nouvelles aryloxymethyl-5 amino-2 oxazolines, syntheses et applications therapeutiques
EP1030849A1 (en) 1997-11-12 2000-08-30 The Pennsylvania State University Transition metal-catalyzed reactions based on chiral amine oxazolinyl ligands
US6476233B1 (en) 1998-11-12 2002-11-05 The Penn State Research Foundation Transition metal-catalyzed reactions based on chiral amine oxazolinyl ligands and related compounds
KR101335845B1 (ko) * 2007-02-15 2013-12-02 에프. 호프만-라 로슈 아게 Ｔａａｒ1 리간드로서의 2-아미노옥사졸린
DK2970272T3 (en) * 2013-03-14 2019-04-23 Merck Patent Gmbh glycosidase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1247318B (de) * 1960-10-13 1967-08-17 Albert Ag Chem Werke Verfahren zur Herstellung von N-[5-Chlormethyloxazolinyl-(2)]-thioharnstoffderivaten
FR2448M (fr) * 1963-02-27 1964-04-06 Mcneilab Inc Composé de la classe des 2-amino-5-aryl-oxazolines et compositions pharmaceutiques le contenant.
US3637726A (en) * 1970-04-09 1972-01-25 Dow Chemical Co Substituted-5-((3 4-dihalophenoxy)methyl)-2-oxazoline compounds
US3930008A (en) * 1972-10-16 1975-12-30 Luso Farmaco Inst 4-Aryl-5-aminoalkyl-4-oxazolin-2-ones

Also Published As

Publication number Publication date
EP0106776B1 (fr) 1986-10-22
ES526275A0 (es) 1984-06-16
EP0106776A1 (fr) 1984-04-25
DE3367098D1 (en) 1986-11-27
JPH0647580B2 (ja) 1994-06-22
US4497812A (en) 1985-02-05
JPS5988475A (ja) 1984-05-22
OA07555A (fr) 1985-03-31
PT77428A (fr) 1983-10-01
CA1217485A (fr) 1987-02-03
PT77428B (fr) 1986-02-27

Similar Documents

Publication Publication Date Title
ES8407025A1 (es) Un procedimiento para preparar derivados de nicotinamida.
ES8404993A1 (es) Procedimiento para preparar derivados de piridina
ES8405766A1 (es) Procedimiento para preparar derivados de fenil-1-piperidino-2-propanol
ES471461A1 (es) Procedimiento para preparar composiciones insecticidas y acaricidas a base de derivados sustituidos de fenoxibencilo-xicarbonilo
GR68522B (es)
ES8704492A1 (es) Metodo de preparar derivados de b-carbolin-3-oxadiazolilo
ES482700A1 (es) Procedimiento para la obtencion de alfa-azolil-beta-hidroxi-cetonas.
ES8506629A1 (es) Un procedimiento para preparar derivados de piridina
ES478156A1 (es) Un metodo de preparacion de compuestos heterociclicos derivados de hidantoina.
ES2008962A6 (es) Proceso para la preparacion de nuevos compuestos de 2-guanidinotiazol
ES8201945A1 (es) Un procedimiento para preparar 9-aminoalquilfluorenos
ES8405777A1 (es) Procedimiento de preparacion de nuevas 2-amino 5-aminometil 2-oxazolinas
ES8603184A1 (es) Metodo de preparar un derivado de acido b-carbolin-3-carbo- xilico
ES8403456A1 (es) "procedimiento para la obtencion de una composicion a base de 1,4-dihidropiridina de accion anti-arteriosclerotica".
ES8405619A1 (es) Procedimiento de preparacion de nuevas n-(5-aminometil 2-oxazolin 2-il)-n'-fenilureas
ES8201979A1 (es) Procedimiento para la obtencion de derivados de bifeni- lil-azoliletano
JPS5432468A (en) Pyrrole derivatives
ES446325A1 (es) Procedimiento para preparar tieno-(3,2-c)-piridina y deriva-dos de la misma.
ES407816A1 (es) Metodo para producir derivados de benzodiazepina.
ES8205414A1 (es) Un procedimiento de preparacion de derivados de tiazol
JPS5225765A (en) Preparation of novel isoindoline derivatives
ES8407047A1 (es) Un procedimiento para la preparacion de un compuesto de 5-aril-1,2,3,4-tetrahidro-y-carbolina-2-sustituida.
DE3860117D1 (de) 2,3-dihydro-3-phenyl-benzofuran-2-on-acetamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
GB1526607A (en) Zearalin ethers
JPS5253868A (en) Process for preparing aminopropanol derivative

Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20041102