ES8403456A1 - "procedimiento para la obtencion de una composicion a base de 1,4-dihidropiridina de accion anti-arteriosclerotica". - Google Patents

"procedimiento para la obtencion de una composicion a base de 1,4-dihidropiridina de accion anti-arteriosclerotica".

Info

Publication number
ES8403456A1
ES8403456A1 ES523244A ES523244A ES8403456A1 ES 8403456 A1 ES8403456 A1 ES 8403456A1 ES 523244 A ES523244 A ES 523244A ES 523244 A ES523244 A ES 523244A ES 8403456 A1 ES8403456 A1 ES 8403456A1
Authority
ES
Spain
Prior art keywords
different
antiatherosclerotic
dihydropyridines
arteriosclerosis
alkoxyalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523244A
Other languages
English (en)
Other versions
ES523244A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8403456A1 publication Critical patent/ES8403456A1/es
Publication of ES523244A0 publication Critical patent/ES523244A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

CONSISTE EN LA REACCION DE ALDEHIDOS DE FORMULA (I), EN LA QUE R3 PUEDE SER VARIOS TIPOS DE RADICALES CON UN EQUIVALENTE DE UN B-CETOCOMPUESTO DE FORMULA H3C-CO-CH2COCX, EN LA QUE X ES ALQUILO O ALCOXIALQUILO C12; SEGUIDA DE LA REACCION CON AMONIACO Y OTRO EQUIVALENTE DEL B-CETOCOMPUESTO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, TAL COMO ETANOL, A LA TEMPERATURA DE REFLUJO.
ES523244A 1982-06-15 1983-06-14 "procedimiento para la obtencion de una composicion a base de 1,4-dihidropiridina de accion anti-arteriosclerotica". Granted ES523244A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823222367 DE3222367A1 (de) 1982-06-15 1982-06-15 Verwendung von 1,4-dihydropyridinen in antiarteriosklerotika und deren herstellung

Publications (2)

Publication Number Publication Date
ES8403456A1 true ES8403456A1 (es) 1984-03-16
ES523244A0 ES523244A0 (es) 1984-03-16

Family

ID=6166052

Family Applications (1)

Application Number Title Priority Date Filing Date
ES523244A Granted ES523244A0 (es) 1982-06-15 1983-06-14 "procedimiento para la obtencion de una composicion a base de 1,4-dihidropiridina de accion anti-arteriosclerotica".

Country Status (9)

Country Link
JP (1) JPS595114A (es)
BE (1) BE897035A (es)
CA (1) CA1228549A (es)
DE (1) DE3222367A1 (es)
ES (1) ES523244A0 (es)
FR (1) FR2528425B1 (es)
IL (1) IL68970A0 (es)
IT (1) IT1175920B (es)
ZA (1) ZA834344B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
GB8428552D0 (en) * 1984-11-12 1984-12-19 Sandoz Ltd Organic compounds
US5260321A (en) * 1984-11-12 1993-11-09 Sandoz Ltd. Use of 1,4-dihydropyridine derivatives and combinations thereof with calcitonins
GB8431119D0 (en) * 1984-12-10 1985-01-16 Fujisawa Pharmaceutical Co Anti-arteriosclerotic composition
GB2180532B (en) * 1985-09-17 1989-08-23 Inst Organicheskogo Sinteza Ak Alkoxy-and phenoxy-alkyl-esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid
DE4222770A1 (de) * 1992-07-10 1994-01-13 Bayer Ag Lichtaktivierbare 1-(2-Nitrobenzyl)-substituierte 1,4-Dihydropyridine
DE4328884A1 (de) * 1993-08-27 1995-03-02 Bayer Ag Verwendung von N-alkylierten 1,4-Dihydropyridincarbonsäureestern als Arzneimittel
AU2002361992A1 (en) * 2001-12-20 2003-07-09 Bayer Aktiengesellschaft 1,4-dihydro-1,4-diphenylpyridine derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2117573C3 (de) * 1971-04-10 1978-07-27 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel
DE2335466A1 (de) * 1973-07-12 1975-01-30 Bayer Ag Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2549568C3 (de) * 1975-11-05 1981-10-29 Bayer Ag, 5090 Leverkusen 2,6-Dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl)-1,4-dihydropyridin-5- carbonsäureisobutylester, mehrere Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel
DE3033919A1 (de) * 1980-09-09 1982-04-22 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
DE3222367A1 (de) 1983-12-15
IT8321465A0 (it) 1983-06-03
FR2528425A1 (fr) 1983-12-16
JPS595114A (ja) 1984-01-12
CA1228549A (en) 1987-10-27
IT1175920B (it) 1987-08-12
BE897035A (fr) 1983-12-13
JPH0553774B2 (es) 1993-08-10
DE3222367C2 (es) 1992-02-13
ZA834344B (en) 1984-03-28
ES523244A0 (es) 1984-03-16
FR2528425B1 (fr) 1987-02-06
IL68970A0 (en) 1983-10-31

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