IT8120271A0 - Derivati pirazolopiridinici utili come cardiotonici e loro preparazione. - Google Patents
Derivati pirazolopiridinici utili come cardiotonici e loro preparazione.Info
- Publication number
- IT8120271A0 IT8120271A0 IT8120271A IT2027181A IT8120271A0 IT 8120271 A0 IT8120271 A0 IT 8120271A0 IT 8120271 A IT8120271 A IT 8120271A IT 2027181 A IT2027181 A IT 2027181A IT 8120271 A0 IT8120271 A0 IT 8120271A0
- Authority
- IT
- Italy
- Prior art keywords
- cardiotonics
- preparation
- derivatives useful
- pyrazolopyridine derivatives
- pyrazolopyridine
- Prior art date
Links
- 239000000496 cardiotonic agent Substances 0.000 title 1
- 150000005229 pyrazolopyridines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/131,227 US4264603A (en) | 1980-03-17 | 1980-03-17 | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8120271A0 true IT8120271A0 (it) | 1981-03-10 |
| IT1141998B IT1141998B (it) | 1986-10-08 |
Family
ID=22448499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT20271/81A IT1141998B (it) | 1980-03-17 | 1981-03-10 | Derivati pirazolopiridinici utili come cardiotonici e loro preparazione |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4264603A (it) |
| JP (1) | JPS56142281A (it) |
| KR (1) | KR830005214A (it) |
| AU (1) | AU6826081A (it) |
| BE (1) | BE887890A (it) |
| DE (1) | DE3109768A1 (it) |
| DK (1) | DK114381A (it) |
| ES (1) | ES500412A0 (it) |
| FI (1) | FI810759L (it) |
| FR (1) | FR2478100A1 (it) |
| GB (1) | GB2071660A (it) |
| IL (1) | IL62295A0 (it) |
| IT (1) | IT1141998B (it) |
| LU (1) | LU83214A1 (it) |
| NL (1) | NL8101217A (it) |
| NO (1) | NO810834L (it) |
| PT (1) | PT72654B (it) |
| SE (1) | SE8101591L (it) |
| ZA (1) | ZA811418B (it) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4361568A (en) * | 1981-04-28 | 1982-11-30 | Sterling Drug Inc. | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use |
| US4374141A (en) * | 1981-08-17 | 1983-02-15 | Sterling Drug Inc. | 2-Substituted amino-5-(pyridinyl)-nicotinamides and their cardiotonic use |
| EP0200024B1 (de) | 1985-04-30 | 1992-07-01 | ARZNEIMITTELWERK DRESDEN GmbH | 3-Cyan-pyridine, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| DD298781A5 (de) * | 1990-03-09 | 1992-03-12 | Inst Wirkstofforschung | Verfahren zur herstellung von 5,4'-bipyridin-1'-oxiden |
| WO2004076450A1 (en) * | 2003-02-27 | 2004-09-10 | J. Uriach Y Compañia S.A. | Pyrazolopyridine derivates |
| US20090008238A1 (en) * | 2004-04-09 | 2009-01-08 | The Arizona Bd Of Reg On Behalf Of The Univ Of Az | Transportable gas sterilization unit, disposable gas generator, light activated anti-infective coating and method of disinfection and sterilization using chlorine dioxide |
| TW200618800A (en) * | 2004-08-03 | 2006-06-16 | Uriach Y Compania S A J | Heterocyclic compounds |
| CN102558044A (zh) * | 2011-12-29 | 2012-07-11 | 方晏燕 | 米力农的结晶方法 |
| CN103664773A (zh) * | 2013-12-18 | 2014-03-26 | 南京易亨制药有限公司 | 米力农的制备方法和精制方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3423414A (en) * | 1966-01-13 | 1969-01-21 | Ciba Geigy Corp | Pyrazolopyridines |
| DE2160780A1 (de) * | 1971-12-08 | 1973-06-14 | Basf Ag | Pyridino-pyrazole |
| DE2232038A1 (de) * | 1972-06-30 | 1974-01-10 | Hoechst Ag | 3-amino-1h-pyrazolo eckige klammer auf 3,4-b eckige klammer zu pyridine, ihre herstellung und verwendung |
| US4072746A (en) * | 1975-10-14 | 1978-02-07 | Sterling Drug Inc. | 3-Amino-5-(pyridinyl)-2(1H)-pyridinones |
| US4004012A (en) * | 1975-10-14 | 1977-01-18 | Sterling Drug Inc. | 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones |
| US4020072A (en) * | 1976-05-04 | 1977-04-26 | E. R. Squibb & Sons, Inc. | 5-Aminomethyl-1H-pyrazolo[3,4-b]pyridines |
-
1980
- 1980-03-17 US US06/131,227 patent/US4264603A/en not_active Expired - Lifetime
-
1981
- 1981-03-04 ZA ZA00811418A patent/ZA811418B/xx unknown
- 1981-03-04 IL IL62295A patent/IL62295A0/xx unknown
- 1981-03-09 FR FR8104624A patent/FR2478100A1/fr not_active Withdrawn
- 1981-03-10 IT IT20271/81A patent/IT1141998B/it active
- 1981-03-11 GB GB8107631A patent/GB2071660A/en not_active Withdrawn
- 1981-03-11 NO NO810834A patent/NO810834L/no unknown
- 1981-03-11 FI FI810759A patent/FI810759L/fi not_active Application Discontinuation
- 1981-03-11 BE BE1/10167A patent/BE887890A/fr unknown
- 1981-03-11 AU AU68260/81A patent/AU6826081A/en not_active Abandoned
- 1981-03-12 KR KR1019810000800A patent/KR830005214A/ko unknown
- 1981-03-12 LU LU83214A patent/LU83214A1/fr unknown
- 1981-03-12 PT PT72654A patent/PT72654B/pt unknown
- 1981-03-12 NL NL8101217A patent/NL8101217A/nl not_active Application Discontinuation
- 1981-03-12 SE SE8101591A patent/SE8101591L/xx not_active Application Discontinuation
- 1981-03-13 JP JP3641981A patent/JPS56142281A/ja active Pending
- 1981-03-13 DE DE19813109768 patent/DE3109768A1/de not_active Withdrawn
- 1981-03-13 DK DK114381A patent/DK114381A/da unknown
- 1981-03-16 ES ES500412A patent/ES500412A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| SE8101591L (sv) | 1981-09-18 |
| ES8202339A1 (es) | 1982-01-16 |
| ZA811418B (en) | 1982-03-31 |
| AU6826081A (en) | 1981-09-24 |
| PT72654B (en) | 1982-03-19 |
| FR2478100A1 (fr) | 1981-09-18 |
| JPS56142281A (en) | 1981-11-06 |
| BE887890A (fr) | 1981-09-11 |
| IL62295A0 (en) | 1981-05-20 |
| NL8101217A (nl) | 1981-10-16 |
| NO810834L (no) | 1981-09-18 |
| DE3109768A1 (de) | 1981-12-24 |
| DK114381A (da) | 1981-09-18 |
| US4264603A (en) | 1981-04-28 |
| PT72654A (en) | 1981-04-01 |
| FI810759L (fi) | 1981-09-18 |
| KR830005214A (ko) | 1983-08-03 |
| LU83214A1 (fr) | 1981-10-30 |
| IT1141998B (it) | 1986-10-08 |
| ES500412A0 (es) | 1982-01-16 |
| GB2071660A (en) | 1981-09-23 |
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