JPS5724369A - Pyrimidine derivative and its preparation - Google Patents
Pyrimidine derivative and its preparationInfo
- Publication number
- JPS5724369A JPS5724369A JP9904580A JP9904580A JPS5724369A JP S5724369 A JPS5724369 A JP S5724369A JP 9904580 A JP9904580 A JP 9904580A JP 9904580 A JP9904580 A JP 9904580A JP S5724369 A JPS5724369 A JP S5724369A
- Authority
- JP
- Japan
- Prior art keywords
- group
- fluorouracil
- hetero atom
- formula
- pyrimidine derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The pyrimidine derivative of formula I [X and Y are H or group of formula II (R, R', R" and R''' are alkyl, aryl, etc.: W and W' are hetero atom or hetero atom group; V and V' are heterocyclic ring, etc.; K and K' are 0W10; l, l', m, m', n, and n' are 0W6)].
EXAMPLE: 1-(α-Acetoxyfurfuryl)-5-fluorouracil.
USE: Carcinostatic agent. The characteristic feature of the compound is the introduction of a group which can be coordinated with a polar group or metal, e.g. hetero atom, hetero atom group, hetero-cyclic ring, double bond, etc., or introduction of a crosslinkable aliphatic hydrocarbon group. It has high affinity to the cancerous tissue and low toxicity.
PROCESS: The objective compound is prepared by reacting the chloride of formula III with 5-fluorouracil (pref. 1-acetyl-5-fluorouracil or 1-alkoxycarbonyl-5-fluorouracil).
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9904580A JPS5724369A (en) | 1980-07-19 | 1980-07-19 | Pyrimidine derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9904580A JPS5724369A (en) | 1980-07-19 | 1980-07-19 | Pyrimidine derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5724369A true JPS5724369A (en) | 1982-02-08 |
Family
ID=14236537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9904580A Pending JPS5724369A (en) | 1980-07-19 | 1980-07-19 | Pyrimidine derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5724369A (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6069083A (en) * | 1983-08-02 | 1985-04-19 | アメリカン・サイアナミド・カンパニ− | Dihydroimidazopyrrolopyridines and derivatives |
JPS6087272A (en) * | 1983-10-20 | 1985-05-16 | Terumo Corp | 5-fluorouracil derivative and blood platelet coagulation inhibitor containing the same |
DE3524179A1 (en) * | 1984-07-06 | 1986-01-16 | Ricoh Co., Ltd., Tokio/Tokyo | METHOD FOR PRODUCING POLYMER PARTICLES |
JPS61215602A (en) * | 1985-03-22 | 1986-09-25 | Japan Synthetic Rubber Co Ltd | Production of polymer particle |
JPS6481810A (en) * | 1987-09-22 | 1989-03-28 | Kao Corp | Production of fine polymer particle having uniform particle diameter |
US5942292A (en) * | 1996-12-20 | 1999-08-24 | Kao Corporation | Spacer for liquid crystal display and liquid crystal display made by using the same |
US7732051B2 (en) | 2006-07-26 | 2010-06-08 | Jsr Corporation | Polymer-coated magnetic particles comprising a 2,3-hydroxypropyl group, and probe-bonded particles |
US7981512B2 (en) | 2006-09-28 | 2011-07-19 | Jsr Corporation | Organic polymer-magnetic particles and process for producing same |
US8703289B2 (en) | 2005-11-01 | 2014-04-22 | Jsr Corporation | Organic polymer particles and process for producing the same, magnetic particles for diagnostics, carboxyl group-containing particles and process for producing the same, and probe-bound particles and process for producing the same |
US8846877B2 (en) | 2008-09-25 | 2014-09-30 | Jsr Corporation | Packing material for affinity chromatography |
US9447232B2 (en) | 2005-05-20 | 2016-09-20 | Jsr Corporation | Carrier polymer particle, process for producing the same, magnetic particle for specific trapping, and process for producing the same |
US11320430B2 (en) | 2016-12-28 | 2022-05-03 | Jsr Corporation | Magnetic particle dispersion |
US11366108B2 (en) | 2017-03-31 | 2022-06-21 | Jsr Corporation | Method of producing probe-bound carrier, probe-bound carrier and method of detecting or separating target substance |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5198280A (en) * | 1975-02-17 | 1976-08-30 | 11 * arufua ashirokishiarukiru * 55 furuororashiruruinoseizohoho | |
JPS5331676A (en) * | 1976-09-06 | 1978-03-25 | Mitsui Toatsu Chem Inc | Uracil derivatives and their preparation |
JPS54122281A (en) * | 1978-03-13 | 1979-09-21 | Mitsui Toatsu Chem Inc | 5-fluorouracil derivative and its preparation |
-
1980
- 1980-07-19 JP JP9904580A patent/JPS5724369A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5198280A (en) * | 1975-02-17 | 1976-08-30 | 11 * arufua ashirokishiarukiru * 55 furuororashiruruinoseizohoho | |
JPS5331676A (en) * | 1976-09-06 | 1978-03-25 | Mitsui Toatsu Chem Inc | Uracil derivatives and their preparation |
JPS54122281A (en) * | 1978-03-13 | 1979-09-21 | Mitsui Toatsu Chem Inc | 5-fluorouracil derivative and its preparation |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0670054B2 (en) * | 1983-08-02 | 1994-09-07 | アメリカン・サイアナミド・カンパニ− | Dihydroimidazopyrrolopyridines and their derivatives |
JPS6069083A (en) * | 1983-08-02 | 1985-04-19 | アメリカン・サイアナミド・カンパニ− | Dihydroimidazopyrrolopyridines and derivatives |
JPH0369326B2 (en) * | 1983-10-20 | 1991-10-31 | Terumo Corp | |
JPS6087272A (en) * | 1983-10-20 | 1985-05-16 | Terumo Corp | 5-fluorouracil derivative and blood platelet coagulation inhibitor containing the same |
DE3524179A1 (en) * | 1984-07-06 | 1986-01-16 | Ricoh Co., Ltd., Tokio/Tokyo | METHOD FOR PRODUCING POLYMER PARTICLES |
DE3524179C2 (en) * | 1984-07-06 | 1987-11-19 | Ricoh Co., Ltd., Tokio/Tokyo, Jp | |
JPH0651728B2 (en) * | 1985-03-22 | 1994-07-06 | 日本合成ゴム株式会社 | Method for producing polymer particles |
JPS61215602A (en) * | 1985-03-22 | 1986-09-25 | Japan Synthetic Rubber Co Ltd | Production of polymer particle |
JPH0564964B2 (en) * | 1987-09-22 | 1993-09-16 | Kao Corp | |
JPS6481810A (en) * | 1987-09-22 | 1989-03-28 | Kao Corp | Production of fine polymer particle having uniform particle diameter |
US5496897A (en) * | 1987-09-22 | 1996-03-05 | Kao Corporation | Process for preparing uniformly sized, fine particles of polymer |
US5942292A (en) * | 1996-12-20 | 1999-08-24 | Kao Corporation | Spacer for liquid crystal display and liquid crystal display made by using the same |
US9447232B2 (en) | 2005-05-20 | 2016-09-20 | Jsr Corporation | Carrier polymer particle, process for producing the same, magnetic particle for specific trapping, and process for producing the same |
US8703289B2 (en) | 2005-11-01 | 2014-04-22 | Jsr Corporation | Organic polymer particles and process for producing the same, magnetic particles for diagnostics, carboxyl group-containing particles and process for producing the same, and probe-bound particles and process for producing the same |
US7732051B2 (en) | 2006-07-26 | 2010-06-08 | Jsr Corporation | Polymer-coated magnetic particles comprising a 2,3-hydroxypropyl group, and probe-bonded particles |
US7981512B2 (en) | 2006-09-28 | 2011-07-19 | Jsr Corporation | Organic polymer-magnetic particles and process for producing same |
US8846877B2 (en) | 2008-09-25 | 2014-09-30 | Jsr Corporation | Packing material for affinity chromatography |
US11320430B2 (en) | 2016-12-28 | 2022-05-03 | Jsr Corporation | Magnetic particle dispersion |
US11366108B2 (en) | 2017-03-31 | 2022-06-21 | Jsr Corporation | Method of producing probe-bound carrier, probe-bound carrier and method of detecting or separating target substance |
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