JPS5649363A - Carbostyril derivative - Google Patents

Carbostyril derivative

Info

Publication number
JPS5649363A
JPS5649363A JP12556679A JP12556679A JPS5649363A JP S5649363 A JPS5649363 A JP S5649363A JP 12556679 A JP12556679 A JP 12556679A JP 12556679 A JP12556679 A JP 12556679A JP S5649363 A JPS5649363 A JP S5649363A
Authority
JP
Japan
Prior art keywords
formula
halogen
compound
carbostyril
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12556679A
Other languages
Japanese (ja)
Other versions
JPS6230989B2 (en
Inventor
Kazuhisa Sakano
Takafumi Fujioka
Yasuo Oshiro
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP12556679A priority Critical patent/JPS5649363A/en
Publication of JPS5649363A publication Critical patent/JPS5649363A/en
Publication of JPS6230989B2 publication Critical patent/JPS6230989B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

NEW MATERIAL:A carbostyril derivative of formula I (R1 is H or lower alkyl; R2 is halogen-substituted lower alkanoyl or halogen-substituted lower alkyl; the bond between the 3- and the 4-carbon atoms in the carbostyril skeleton is single or double bond.) and its salt.
EXAMPLE: 6-(β-Chloropropionylamino)carbostyril.
USE: A phosphodiesterase inhibitor, a blood platelet coagulation inhibiting agent, (antithrombic agent), antibacterial agent, and intermediaters of central nervous system depressants (some of which are novel) and antihistaminic agents.
PROCESS: The compound of formula I is prepared by reacting a compound of formula II with a compound of formula R2' -X1 (X is halogen; R2' is halogen-substituted lower alkyl) or formula R2"-OH(R2" is halogen-substotituted lower alkanoyl). A compound of formula III (A is CO; l is 0 or 1; Y is lower alkylene; X2 is halogen) which is one of the compounds of formula I, can be converted to a novel compound of formula VI (R3 is halogen, etc.; n is 0W3) useful as a central nervous system depressant, etc.
COPYRIGHT: (C)1981,JPO&Japio
JP12556679A 1979-09-28 1979-09-28 Carbostyril derivative Granted JPS5649363A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12556679A JPS5649363A (en) 1979-09-28 1979-09-28 Carbostyril derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12556679A JPS5649363A (en) 1979-09-28 1979-09-28 Carbostyril derivative

Publications (2)

Publication Number Publication Date
JPS5649363A true JPS5649363A (en) 1981-05-02
JPS6230989B2 JPS6230989B2 (en) 1987-07-06

Family

ID=14913357

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12556679A Granted JPS5649363A (en) 1979-09-28 1979-09-28 Carbostyril derivative

Country Status (1)

Country Link
JP (1) JPS5649363A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60209567A (en) * 1984-03-27 1985-10-22 マイルス・ラボラトリーズ・インコーポレーテツド Fluorescent dihydroquinone and dihydrocoumarin hydrogen peroxide indicator
JPS61145162A (en) * 1984-12-19 1986-07-02 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
EP0236140A2 (en) * 1986-03-05 1987-09-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
JPS63225357A (en) * 1987-03-12 1988-09-20 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS63301821A (en) * 1986-03-05 1988-12-08 Otsuka Pharmaceut Co Ltd Antiarrhythmic agent
JPS6434963A (en) * 1986-03-05 1989-02-06 Otsuka Pharma Co Ltd Carbostyril derivative
JPH06192229A (en) * 1992-12-26 1994-07-12 Kissei Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative
US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60209567A (en) * 1984-03-27 1985-10-22 マイルス・ラボラトリーズ・インコーポレーテツド Fluorescent dihydroquinone and dihydrocoumarin hydrogen peroxide indicator
JPH0472519B2 (en) * 1984-03-27 1992-11-18 Miles Inc
JPS61145162A (en) * 1984-12-19 1986-07-02 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
EP0236140A2 (en) * 1986-03-05 1987-09-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
JPS63301821A (en) * 1986-03-05 1988-12-08 Otsuka Pharmaceut Co Ltd Antiarrhythmic agent
JPS6434963A (en) * 1986-03-05 1989-02-06 Otsuka Pharma Co Ltd Carbostyril derivative
US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
JPS63225357A (en) * 1987-03-12 1988-09-20 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPH06192229A (en) * 1992-12-26 1994-07-12 Kissei Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative

Also Published As

Publication number Publication date
JPS6230989B2 (en) 1987-07-06

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