JPS5649363A - Carbostyril derivative - Google Patents
Carbostyril derivativeInfo
- Publication number
- JPS5649363A JPS5649363A JP12556679A JP12556679A JPS5649363A JP S5649363 A JPS5649363 A JP S5649363A JP 12556679 A JP12556679 A JP 12556679A JP 12556679 A JP12556679 A JP 12556679A JP S5649363 A JPS5649363 A JP S5649363A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- halogen
- compound
- carbostyril
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
NEW MATERIAL:A carbostyril derivative of formula I (R1 is H or lower alkyl; R2 is halogen-substituted lower alkanoyl or halogen-substituted lower alkyl; the bond between the 3- and the 4-carbon atoms in the carbostyril skeleton is single or double bond.) and its salt.
EXAMPLE: 6-(β-Chloropropionylamino)carbostyril.
USE: A phosphodiesterase inhibitor, a blood platelet coagulation inhibiting agent, (antithrombic agent), antibacterial agent, and intermediaters of central nervous system depressants (some of which are novel) and antihistaminic agents.
PROCESS: The compound of formula I is prepared by reacting a compound of formula II with a compound of formula R2' -X1 (X is halogen; R2' is halogen-substituted lower alkyl) or formula R2"-OH(R2" is halogen-substotituted lower alkanoyl). A compound of formula III (A is CO; l is 0 or 1; Y is lower alkylene; X2 is halogen) which is one of the compounds of formula I, can be converted to a novel compound of formula VI (R3 is halogen, etc.; n is 0W3) useful as a central nervous system depressant, etc.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12556679A JPS5649363A (en) | 1979-09-28 | 1979-09-28 | Carbostyril derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12556679A JPS5649363A (en) | 1979-09-28 | 1979-09-28 | Carbostyril derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5649363A true JPS5649363A (en) | 1981-05-02 |
JPS6230989B2 JPS6230989B2 (en) | 1987-07-06 |
Family
ID=14913357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12556679A Granted JPS5649363A (en) | 1979-09-28 | 1979-09-28 | Carbostyril derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5649363A (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60209567A (en) * | 1984-03-27 | 1985-10-22 | マイルス・ラボラトリーズ・インコーポレーテツド | Fluorescent dihydroquinone and dihydrocoumarin hydrogen peroxide indicator |
JPS61145162A (en) * | 1984-12-19 | 1986-07-02 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
EP0236140A2 (en) * | 1986-03-05 | 1987-09-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives |
JPS63225357A (en) * | 1987-03-12 | 1988-09-20 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
JPS63301821A (en) * | 1986-03-05 | 1988-12-08 | Otsuka Pharmaceut Co Ltd | Antiarrhythmic agent |
JPS6434963A (en) * | 1986-03-05 | 1989-02-06 | Otsuka Pharma Co Ltd | Carbostyril derivative |
JPH06192229A (en) * | 1992-12-26 | 1994-07-12 | Kissei Pharmaceut Co Ltd | 3,4-dihydrocarbostyril derivative |
US5358949A (en) * | 1986-03-05 | 1994-10-25 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives |
-
1979
- 1979-09-28 JP JP12556679A patent/JPS5649363A/en active Granted
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60209567A (en) * | 1984-03-27 | 1985-10-22 | マイルス・ラボラトリーズ・インコーポレーテツド | Fluorescent dihydroquinone and dihydrocoumarin hydrogen peroxide indicator |
JPH0472519B2 (en) * | 1984-03-27 | 1992-11-18 | Miles Inc | |
JPS61145162A (en) * | 1984-12-19 | 1986-07-02 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
EP0236140A2 (en) * | 1986-03-05 | 1987-09-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives |
JPS63301821A (en) * | 1986-03-05 | 1988-12-08 | Otsuka Pharmaceut Co Ltd | Antiarrhythmic agent |
JPS6434963A (en) * | 1986-03-05 | 1989-02-06 | Otsuka Pharma Co Ltd | Carbostyril derivative |
US5358949A (en) * | 1986-03-05 | 1994-10-25 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives |
JPS63225357A (en) * | 1987-03-12 | 1988-09-20 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
JPH06192229A (en) * | 1992-12-26 | 1994-07-12 | Kissei Pharmaceut Co Ltd | 3,4-dihydrocarbostyril derivative |
Also Published As
Publication number | Publication date |
---|---|
JPS6230989B2 (en) | 1987-07-06 |
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