JPS5576864A - Carbostyril derivative - Google Patents

Carbostyril derivative

Info

Publication number
JPS5576864A
JPS5576864A JP15182878A JP15182878A JPS5576864A JP S5576864 A JPS5576864 A JP S5576864A JP 15182878 A JP15182878 A JP 15182878A JP 15182878 A JP15182878 A JP 15182878A JP S5576864 A JPS5576864 A JP S5576864A
Authority
JP
Japan
Prior art keywords
formula
carbostyril
derivative
compound
bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15182878A
Other languages
Japanese (ja)
Other versions
JPS6129343B2 (en
Inventor
Takao Nishi
Tatsuyoshi Tanaka
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP15182878A priority Critical patent/JPS5576864A/en
Publication of JPS5576864A publication Critical patent/JPS5576864A/en
Publication of JPS6129343B2 publication Critical patent/JPS6129343B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A carbostyril derivative of formula I: (R1 is lower alkyl group; R2 is cycloalkyl group; the bond between the 3- and 4-positions of the carbostyril skeleton is single or double bond).
EXAMPLE: 6-[3-(N-Methyl-N-cyclohexylaminocarbonyl)-2-propenyloxy]-carbostyril.
USE: Preventive and treating agents for thrombosis, antitumor agents, and antiphlogistics, and an intermediate for the synthesis of carbostyril derivatives of formula II, having improved blood platelet antiagglutinating, phosphodiesterase inhibitory and anti-inflammatory actions.
PROCESS: A hydroxycarbostyril devivative of formula III is reacted with a halocrotonamide derivative of formula IV: (X is halogen), which may be novel, in the presence of a dehydrohalogenating agent of a basic compound, e.g. K2CO3, to give the desired compound of formula I, which is simply hydrogenated to form a compound of formula II in high yield.
COPYRIGHT: (C)1980,JPO&Japio
JP15182878A 1978-12-06 1978-12-06 Carbostyril derivative Granted JPS5576864A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15182878A JPS5576864A (en) 1978-12-06 1978-12-06 Carbostyril derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15182878A JPS5576864A (en) 1978-12-06 1978-12-06 Carbostyril derivative

Publications (2)

Publication Number Publication Date
JPS5576864A true JPS5576864A (en) 1980-06-10
JPS6129343B2 JPS6129343B2 (en) 1986-07-05

Family

ID=15527191

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15182878A Granted JPS5576864A (en) 1978-12-06 1978-12-06 Carbostyril derivative

Country Status (1)

Country Link
JP (1) JPS5576864A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989010919A1 (en) 1988-05-02 1989-11-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102170844B1 (en) * 2018-03-14 2020-10-27 주식회사 산타 Lecture voice file text conversion system based on lecture-related keywords

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51133284A (en) * 1975-05-15 1976-11-18 Otsuka Pharmaceut Co Ltd A process for preparing carbostyril derivatives
JPS51136677A (en) * 1975-05-16 1976-11-26 Otsuka Pharmaceut Co Ltd Process for preparation of carbostyril derivatives
JPS51136676A (en) * 1975-05-16 1976-11-26 Otsuka Pharmaceut Co Ltd Process for preparation of carbostyril derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51133284A (en) * 1975-05-15 1976-11-18 Otsuka Pharmaceut Co Ltd A process for preparing carbostyril derivatives
JPS51136677A (en) * 1975-05-16 1976-11-26 Otsuka Pharmaceut Co Ltd Process for preparation of carbostyril derivatives
JPS51136676A (en) * 1975-05-16 1976-11-26 Otsuka Pharmaceut Co Ltd Process for preparation of carbostyril derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989010919A1 (en) 1988-05-02 1989-11-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Also Published As

Publication number Publication date
JPS6129343B2 (en) 1986-07-05

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