JPS5576864A - Carbostyril derivative - Google Patents
Carbostyril derivativeInfo
- Publication number
- JPS5576864A JPS5576864A JP15182878A JP15182878A JPS5576864A JP S5576864 A JPS5576864 A JP S5576864A JP 15182878 A JP15182878 A JP 15182878A JP 15182878 A JP15182878 A JP 15182878A JP S5576864 A JPS5576864 A JP S5576864A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- carbostyril
- derivative
- compound
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A carbostyril derivative of formula I: (R1 is lower alkyl group; R2 is cycloalkyl group; the bond between the 3- and 4-positions of the carbostyril skeleton is single or double bond).
EXAMPLE: 6-[3-(N-Methyl-N-cyclohexylaminocarbonyl)-2-propenyloxy]-carbostyril.
USE: Preventive and treating agents for thrombosis, antitumor agents, and antiphlogistics, and an intermediate for the synthesis of carbostyril derivatives of formula II, having improved blood platelet antiagglutinating, phosphodiesterase inhibitory and anti-inflammatory actions.
PROCESS: A hydroxycarbostyril devivative of formula III is reacted with a halocrotonamide derivative of formula IV: (X is halogen), which may be novel, in the presence of a dehydrohalogenating agent of a basic compound, e.g. K2CO3, to give the desired compound of formula I, which is simply hydrogenated to form a compound of formula II in high yield.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15182878A JPS5576864A (en) | 1978-12-06 | 1978-12-06 | Carbostyril derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15182878A JPS5576864A (en) | 1978-12-06 | 1978-12-06 | Carbostyril derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5576864A true JPS5576864A (en) | 1980-06-10 |
JPS6129343B2 JPS6129343B2 (en) | 1986-07-05 |
Family
ID=15527191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15182878A Granted JPS5576864A (en) | 1978-12-06 | 1978-12-06 | Carbostyril derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5576864A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989010919A1 (en) | 1988-05-02 | 1989-11-16 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102170844B1 (en) * | 2018-03-14 | 2020-10-27 | 주식회사 산타 | Lecture voice file text conversion system based on lecture-related keywords |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51133284A (en) * | 1975-05-15 | 1976-11-18 | Otsuka Pharmaceut Co Ltd | A process for preparing carbostyril derivatives |
JPS51136676A (en) * | 1975-05-16 | 1976-11-26 | Otsuka Pharmaceut Co Ltd | Process for preparation of carbostyril derivatives |
JPS51136677A (en) * | 1975-05-16 | 1976-11-26 | Otsuka Pharmaceut Co Ltd | Process for preparation of carbostyril derivatives |
-
1978
- 1978-12-06 JP JP15182878A patent/JPS5576864A/en active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51133284A (en) * | 1975-05-15 | 1976-11-18 | Otsuka Pharmaceut Co Ltd | A process for preparing carbostyril derivatives |
JPS51136676A (en) * | 1975-05-16 | 1976-11-26 | Otsuka Pharmaceut Co Ltd | Process for preparation of carbostyril derivatives |
JPS51136677A (en) * | 1975-05-16 | 1976-11-26 | Otsuka Pharmaceut Co Ltd | Process for preparation of carbostyril derivatives |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989010919A1 (en) | 1988-05-02 | 1989-11-16 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS6129343B2 (en) | 1986-07-05 |
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