JPS5579371A - Carbostyril derivative - Google Patents

Carbostyril derivative

Info

Publication number
JPS5579371A
JPS5579371A JP15288178A JP15288178A JPS5579371A JP S5579371 A JPS5579371 A JP S5579371A JP 15288178 A JP15288178 A JP 15288178A JP 15288178 A JP15288178 A JP 15288178A JP S5579371 A JPS5579371 A JP S5579371A
Authority
JP
Japan
Prior art keywords
formula
carbostyril
carbostyril derivative
substituent
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15288178A
Other languages
Japanese (ja)
Other versions
JPS6140226B2 (en
Inventor
Takao Nishi
Tatsuyoshi Tanaka
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP15288178A priority Critical patent/JPS5579371A/en
Publication of JPS5579371A publication Critical patent/JPS5579371A/en
Publication of JPS6140226B2 publication Critical patent/JPS6140226B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A carbostyril derivative of formula I: (R1 is lower alkyl group; R2 is cycloalkyl group having an oxo group as a substituent; the bond between the carbon atoms at the 3-and 4-positions of the carbostyril skeleton is single or double bond).
EXAMPLE: 6-[3-[ N-Methyl-N-( 4-oxo-cyclohexyl )aminocarbonyl ]propoxy]-carbostyril.
USE: Preventives and treating agents for thrombosis, drugs for ulcers, or anti-inflammatory agents, having improved blood platelet antiagglutinating, phosphodiesterase inhibitory, and anti-inflammatory actions.
PROCESS: A carboxypropoxys carbostyril derivative of formula II is reacted with an amine of formula III: (R3 is cycloalkyl group having OH as a substituent) to give a compound of formula IV, which is oxidized, to form the objective compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP15288178A 1978-12-08 1978-12-08 Carbostyril derivative Granted JPS5579371A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15288178A JPS5579371A (en) 1978-12-08 1978-12-08 Carbostyril derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15288178A JPS5579371A (en) 1978-12-08 1978-12-08 Carbostyril derivative

Publications (2)

Publication Number Publication Date
JPS5579371A true JPS5579371A (en) 1980-06-14
JPS6140226B2 JPS6140226B2 (en) 1986-09-08

Family

ID=15550152

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15288178A Granted JPS5579371A (en) 1978-12-08 1978-12-08 Carbostyril derivative

Country Status (1)

Country Link
JP (1) JPS5579371A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989010919A1 (en) 1988-05-02 1989-11-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
US5658926A (en) * 1991-08-23 1997-08-19 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelets aggregation inhibitory agent

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989010919A1 (en) 1988-05-02 1989-11-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
JPH0249768A (en) * 1988-05-02 1990-02-20 Otsuka Pharmaceut Co Ltd Carbostyril derivative
US5658926A (en) * 1991-08-23 1997-08-19 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelets aggregation inhibitory agent

Also Published As

Publication number Publication date
JPS6140226B2 (en) 1986-09-08

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