JPS5579371A - Carbostyril derivative - Google Patents
Carbostyril derivativeInfo
- Publication number
- JPS5579371A JPS5579371A JP15288178A JP15288178A JPS5579371A JP S5579371 A JPS5579371 A JP S5579371A JP 15288178 A JP15288178 A JP 15288178A JP 15288178 A JP15288178 A JP 15288178A JP S5579371 A JPS5579371 A JP S5579371A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- carbostyril
- carbostyril derivative
- substituent
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A carbostyril derivative of formula I: (R1 is lower alkyl group; R2 is cycloalkyl group having an oxo group as a substituent; the bond between the carbon atoms at the 3-and 4-positions of the carbostyril skeleton is single or double bond).
EXAMPLE: 6-[3-[ N-Methyl-N-( 4-oxo-cyclohexyl )aminocarbonyl ]propoxy]-carbostyril.
USE: Preventives and treating agents for thrombosis, drugs for ulcers, or anti-inflammatory agents, having improved blood platelet antiagglutinating, phosphodiesterase inhibitory, and anti-inflammatory actions.
PROCESS: A carboxypropoxys carbostyril derivative of formula II is reacted with an amine of formula III: (R3 is cycloalkyl group having OH as a substituent) to give a compound of formula IV, which is oxidized, to form the objective compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15288178A JPS5579371A (en) | 1978-12-08 | 1978-12-08 | Carbostyril derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15288178A JPS5579371A (en) | 1978-12-08 | 1978-12-08 | Carbostyril derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5579371A true JPS5579371A (en) | 1980-06-14 |
JPS6140226B2 JPS6140226B2 (en) | 1986-09-08 |
Family
ID=15550152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15288178A Granted JPS5579371A (en) | 1978-12-08 | 1978-12-08 | Carbostyril derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5579371A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989010919A1 (en) | 1988-05-02 | 1989-11-16 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
US5658926A (en) * | 1991-08-23 | 1997-08-19 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivative and platelets aggregation inhibitory agent |
-
1978
- 1978-12-08 JP JP15288178A patent/JPS5579371A/en active Granted
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989010919A1 (en) | 1988-05-02 | 1989-11-16 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
JPH0249768A (en) * | 1988-05-02 | 1990-02-20 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
US5658926A (en) * | 1991-08-23 | 1997-08-19 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivative and platelets aggregation inhibitory agent |
Also Published As
Publication number | Publication date |
---|---|
JPS6140226B2 (en) | 1986-09-08 |
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