ES8301216A1 - Un procedimiento para la preparacion de derivados de enantolactama. - Google Patents

Un procedimiento para la preparacion de derivados de enantolactama.

Info

Publication number
ES8301216A1
ES8301216A1 ES504790A ES504790A ES8301216A1 ES 8301216 A1 ES8301216 A1 ES 8301216A1 ES 504790 A ES504790 A ES 504790A ES 504790 A ES504790 A ES 504790A ES 8301216 A1 ES8301216 A1 ES 8301216A1
Authority
ES
Spain
Prior art keywords
substituted
alkyl
heteroarlower
lower alkoxy
arloweralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES504790A
Other languages
English (en)
Other versions
ES504790A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8301216A1 publication Critical patent/ES8301216A1/es
Publication of ES504790A0 publication Critical patent/ES504790A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ENANTOLACTAMA, DE FORMULA (I), EN LA QUE R, R , R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE ALQUILACION REDUCTIVA DE UN COMPUESTO DE FORMULA (II) CON RCOCOR , EN LAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION DE ALQUILACION SE REALIZA EN PRESENCIA DE HIDROGENO Y UN CATALIZADOR ADECUADO, O BIEN DE CIANOBOROHIDRURO SODICO. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO INHIBIDORES DE LA ENZIMA QUE CONVIERTE ANGIOTENSINA Y COMO ANTIHIPERTENSIVOS.
ES504790A 1980-08-18 1981-08-17 Un procedimiento para la preparacion de derivados de enantolactama. Granted ES504790A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17914180A 1980-08-18 1980-08-18
US28097181A 1981-07-07 1981-07-07

Publications (2)

Publication Number Publication Date
ES8301216A1 true ES8301216A1 (es) 1982-12-01
ES504790A0 ES504790A0 (es) 1982-12-01

Family

ID=26875027

Family Applications (1)

Application Number Title Priority Date Filing Date
ES504790A Granted ES504790A0 (es) 1980-08-18 1981-08-17 Un procedimiento para la preparacion de derivados de enantolactama.

Country Status (10)

Country Link
EP (1) EP0046289B1 (es)
DE (1) DE3173064D1 (es)
DK (1) DK364381A (es)
ES (1) ES504790A0 (es)
FI (1) FI812539L (es)
GR (1) GR74624B (es)
IL (1) IL63540A0 (es)
NO (1) NO812773L (es)
PL (1) PL232685A1 (es)
PT (1) PT73529A (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3260831D1 (en) * 1981-06-05 1984-10-31 Merck & Co Inc Perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives, process for preparing and pharmceutical composition containing the same
EP0107095B1 (en) * 1982-09-30 1987-09-09 Merck & Co. Inc. 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
US4470988A (en) * 1983-02-10 1984-09-11 Ciba-Geigy Corporation Benzazocinone and benzazoninone derivatives, and their pharmaceutical use
US4537885A (en) * 1983-02-10 1985-08-27 Ciba Geigy Corporation Certain benzazocinone and benzazoninone derivatives
US4460579A (en) * 1983-02-28 1984-07-17 E. R. Squibb & Sons, Inc. Thiazine and thiazepine containing compounds
US4533661A (en) * 1983-03-28 1985-08-06 E. R. Squibb & Sons, Inc. Certain 3-phosphinyl-amino-2-oxo-1H-azepine-1-acetic acid derivatives having anti-hypertensive activity
US4567167A (en) * 1983-03-28 1986-01-28 E. R. Squibb & Sons, Inc. Certain 3-phosphinyl-2-oxo-piperidine-1-acetic acid derivatives having anti-hypertensive activity
US4598071A (en) * 1983-03-28 1986-07-01 E. R. Squibb & Sons, Inc. Certain 3-phosphinyl-amino-2-oxo-1H-azocine or azonine-1-acetic acid derivatives having anti-hypertensive properties
US4474778A (en) * 1983-11-09 1984-10-02 E. R. Squibb & Sons, Inc. Lactam containing compounds, their pharmaceutical compositions and method of use
SU1435151A3 (ru) * 1984-04-10 1988-10-30 Санкио Компани Лимитед (Фирма) Способ получени производных пергидротиазепина или их кислотно-аддитивных фармацевтически приемлемых солей
EP0187037A3 (en) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Piperidine derivatives, their production and use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4192875A (en) * 1979-02-02 1980-03-11 Merck & Co., Inc. Cyclic hexapeptide
US4377515A (en) * 1979-10-01 1983-03-22 Merck & Co., Inc. Long lasting agonists and antagonists of LH-RH

Also Published As

Publication number Publication date
EP0046289A2 (en) 1982-02-24
DE3173064D1 (en) 1986-01-09
FI812539L (fi) 1982-02-19
ES504790A0 (es) 1982-12-01
PL232685A1 (es) 1982-04-26
EP0046289A3 (en) 1982-04-28
GR74624B (es) 1984-06-29
IL63540A0 (en) 1981-11-30
EP0046289B1 (en) 1985-11-27
DK364381A (da) 1982-02-19
NO812773L (no) 1982-02-19
PT73529A (en) 1981-09-01

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