ES8305337A1 - Procedimiento para la preparacion de derivados de caprolactama. - Google Patents

Procedimiento para la preparacion de derivados de caprolactama.

Info

Publication number
ES8305337A1
ES8305337A1 ES504791A ES504791A ES8305337A1 ES 8305337 A1 ES8305337 A1 ES 8305337A1 ES 504791 A ES504791 A ES 504791A ES 504791 A ES504791 A ES 504791A ES 8305337 A1 ES8305337 A1 ES 8305337A1
Authority
ES
Spain
Prior art keywords
alkyl
lower alkyl
hydrogen
heteroarlower
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES504791A
Other languages
English (en)
Other versions
ES504791A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8305337A1 publication Critical patent/ES8305337A1/es
Publication of ES504791A0 publication Critical patent/ES504791A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CAPROLACTAMA. SE HACE REACCIONAR EL COMPUESTO (II) CON UN AGENTE ALQUILANTE CAPAZ DE INTRODUCIR EL GRUPO R-CO-CHR , DESPUES SEPARAR LOS GRUPOS PROTECTORES Y SI SE DESEA AISLAR EL ISOMERO BIOLOGICAMENTE MAS ACTIVO Y/O PREPARAR LA SAL CORRESPONDIENTE. SE OBTIENE EL COMPUESTO (I). LAS SALES PUEDEN FORMARSE POR MEDIOS CONVENCIONALES HACIENDO REACCIONAR LAS FORMAS ACIDA LIBRE O BASICA CON UNO O MAS EQUIVALENTES DE LA BASE O ACIDO APROPIADO EN UN DISOLVENTE EN QUE LA SAL SEA INSOLUBLE O EN UN DISOLVENTE COMO EL AGUA QUE DESPUES SE SEPARA A VACIO O POR LIOFILIZACION O INTERCAMBIANDO LOS CATIONES DE LA SAL EXISTENTE POR OTRO CATION SOBRE UNA RESINA CAMBIADORA.
ES504791A 1980-08-18 1981-08-17 Procedimiento para la preparacion de derivados de caprolactama. Granted ES504791A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17930580A 1980-08-18 1980-08-18
US28258081A 1981-07-13 1981-07-13

Publications (2)

Publication Number Publication Date
ES8305337A1 true ES8305337A1 (es) 1983-04-01
ES504791A0 ES504791A0 (es) 1983-04-01

Family

ID=26875204

Family Applications (2)

Application Number Title Priority Date Filing Date
ES504791A Granted ES504791A0 (es) 1980-08-18 1981-08-17 Procedimiento para la preparacion de derivados de caprolactama.
ES519057A Expired ES8403460A1 (es) 1980-08-18 1983-01-17 Un procedimiento para la preparacion de derivados de caprolactama.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES519057A Expired ES8403460A1 (es) 1980-08-18 1983-01-17 Un procedimiento para la preparacion de derivados de caprolactama.

Country Status (6)

Country Link
EP (1) EP0046291B1 (es)
DE (1) DE3173304D1 (es)
DK (1) DK364181A (es)
ES (2) ES504791A0 (es)
GR (1) GR74635B (es)
PT (1) PT73537B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068173B1 (en) * 1981-06-05 1984-09-26 Merck & Co. Inc. Perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives, process for preparing and pharmceutical composition containing the same
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4410807A (en) * 1982-03-26 1983-10-18 Kay Industries, Inc. Regulating device for polyphase electrical circuits
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
EP0107095B1 (en) * 1982-09-30 1987-09-09 Merck & Co. Inc. 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
US4470988A (en) * 1983-02-10 1984-09-11 Ciba-Geigy Corporation Benzazocinone and benzazoninone derivatives, and their pharmaceutical use
US4537885A (en) * 1983-02-10 1985-08-27 Ciba Geigy Corporation Certain benzazocinone and benzazoninone derivatives
US4711884A (en) * 1983-02-28 1987-12-08 E. R. Squibb & Sons, Inc. Thiazine and thiazepine containing compounds
US4460579A (en) * 1983-02-28 1984-07-17 E. R. Squibb & Sons, Inc. Thiazine and thiazepine containing compounds
US4533661A (en) * 1983-03-28 1985-08-06 E. R. Squibb & Sons, Inc. Certain 3-phosphinyl-amino-2-oxo-1H-azepine-1-acetic acid derivatives having anti-hypertensive activity
US4598071A (en) * 1983-03-28 1986-07-01 E. R. Squibb & Sons, Inc. Certain 3-phosphinyl-amino-2-oxo-1H-azocine or azonine-1-acetic acid derivatives having anti-hypertensive properties
US4567167A (en) * 1983-03-28 1986-01-28 E. R. Squibb & Sons, Inc. Certain 3-phosphinyl-2-oxo-piperidine-1-acetic acid derivatives having anti-hypertensive activity
US4474778A (en) * 1983-11-09 1984-10-02 E. R. Squibb & Sons, Inc. Lactam containing compounds, their pharmaceutical compositions and method of use
JPH0637473B2 (ja) * 1985-10-11 1994-05-18 三共株式会社 ラクタム化合物
ES2061490T3 (es) * 1986-04-04 1994-12-16 Sankyo Co Derivados de perhidrotiazepina y perhidroazepina, su preparacion y uso en terapeutica.
IT1206078B (it) * 1987-06-03 1989-04-14 Polifarma Spa Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
EP1395560A1 (en) 2001-05-23 2004-03-10 Ucb, S.A. 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders
WO2009075788A1 (en) * 2007-12-05 2009-06-18 Semprus Biociences Corporation Synthetic non-fouling amino acids
WO2016141182A1 (en) 2015-03-03 2016-09-09 Yee Richard W Compositions and methods for treating ocular diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4192875A (en) * 1979-02-02 1980-03-11 Merck & Co., Inc. Cyclic hexapeptide
US4377515A (en) * 1979-10-01 1983-03-22 Merck & Co., Inc. Long lasting agonists and antagonists of LH-RH

Also Published As

Publication number Publication date
EP0046291A2 (en) 1982-02-24
EP0046291B1 (en) 1985-12-27
ES519057A0 (es) 1984-03-16
PT73537B (en) 1983-07-04
DK364181A (da) 1982-02-19
PT73537A (en) 1981-09-01
ES8403460A1 (es) 1984-03-16
EP0046291A3 (en) 1982-04-14
DE3173304D1 (en) 1986-02-06
GR74635B (es) 1984-06-29
ES504791A0 (es) 1983-04-01

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