DE3173304D1 - Substituted caprolactam derivatives as antihypertensives, process for preparing them, pharmaceutical composition containing them, and intermediates - Google Patents
Substituted caprolactam derivatives as antihypertensives, process for preparing them, pharmaceutical composition containing them, and intermediatesInfo
- Publication number
- DE3173304D1 DE3173304D1 DE8181106372T DE3173304T DE3173304D1 DE 3173304 D1 DE3173304 D1 DE 3173304D1 DE 8181106372 T DE8181106372 T DE 8181106372T DE 3173304 T DE3173304 T DE 3173304T DE 3173304 D1 DE3173304 D1 DE 3173304D1
- Authority
- DE
- Germany
- Prior art keywords
- antihypertensives
- intermediates
- preparing
- pharmaceutical composition
- composition containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17930580A | 1980-08-18 | 1980-08-18 | |
US28258081A | 1981-07-13 | 1981-07-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3173304D1 true DE3173304D1 (en) | 1986-02-06 |
Family
ID=26875204
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8181106372T Expired DE3173304D1 (en) | 1980-08-18 | 1981-08-17 | Substituted caprolactam derivatives as antihypertensives, process for preparing them, pharmaceutical composition containing them, and intermediates |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0046291B1 (de) |
DE (1) | DE3173304D1 (de) |
DK (1) | DK364181A (de) |
ES (2) | ES504791A0 (de) |
GR (1) | GR74635B (de) |
PT (1) | PT73537B (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0068173B1 (de) * | 1981-06-05 | 1984-09-26 | Merck & Co. Inc. | Perhydro-1,4-thiazepin-5-one und Perhydro-1,4-thiazocin-5-one, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
US4410520A (en) * | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
US4410807A (en) * | 1982-03-26 | 1983-10-18 | Kay Industries, Inc. | Regulating device for polyphase electrical circuits |
US4473575A (en) * | 1982-07-19 | 1984-09-25 | Ciba-Geigy Corporation | 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids |
DE3373469D1 (en) * | 1982-09-30 | 1987-10-15 | Merck & Co Inc | 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents |
US4470988A (en) * | 1983-02-10 | 1984-09-11 | Ciba-Geigy Corporation | Benzazocinone and benzazoninone derivatives, and their pharmaceutical use |
US4537885A (en) * | 1983-02-10 | 1985-08-27 | Ciba Geigy Corporation | Certain benzazocinone and benzazoninone derivatives |
US4711884A (en) * | 1983-02-28 | 1987-12-08 | E. R. Squibb & Sons, Inc. | Thiazine and thiazepine containing compounds |
US4460579A (en) * | 1983-02-28 | 1984-07-17 | E. R. Squibb & Sons, Inc. | Thiazine and thiazepine containing compounds |
US4567167A (en) * | 1983-03-28 | 1986-01-28 | E. R. Squibb & Sons, Inc. | Certain 3-phosphinyl-2-oxo-piperidine-1-acetic acid derivatives having anti-hypertensive activity |
US4533661A (en) * | 1983-03-28 | 1985-08-06 | E. R. Squibb & Sons, Inc. | Certain 3-phosphinyl-amino-2-oxo-1H-azepine-1-acetic acid derivatives having anti-hypertensive activity |
US4598071A (en) * | 1983-03-28 | 1986-07-01 | E. R. Squibb & Sons, Inc. | Certain 3-phosphinyl-amino-2-oxo-1H-azocine or azonine-1-acetic acid derivatives having anti-hypertensive properties |
US4474778A (en) * | 1983-11-09 | 1984-10-02 | E. R. Squibb & Sons, Inc. | Lactam containing compounds, their pharmaceutical compositions and method of use |
JPH0637473B2 (ja) * | 1985-10-11 | 1994-05-18 | 三共株式会社 | ラクタム化合物 |
IE61433B1 (en) * | 1986-04-04 | 1994-11-02 | Sankyo Co | Perhydrothiazepine and perhydroazepine derivatives their preparation and their therapeutic use |
IT1206078B (it) * | 1987-06-03 | 1989-04-14 | Polifarma Spa | Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico |
US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
EP1395560A1 (de) * | 2001-05-23 | 2004-03-10 | Ucb, S.A. | 2-oxopiperidinyl- und 2-oxoazepanylalkansäurederivate zur behandlung von epilepsie und anderen neurologischen erkrankungen |
WO2009075788A1 (en) * | 2007-12-05 | 2009-06-18 | Semprus Biociences Corporation | Synthetic non-fouling amino acids |
WO2016141182A1 (en) | 2015-03-03 | 2016-09-09 | Yee Richard W | Compositions and methods for treating ocular diseases |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
US4192875A (en) * | 1979-02-02 | 1980-03-11 | Merck & Co., Inc. | Cyclic hexapeptide |
US4377515A (en) * | 1979-10-01 | 1983-03-22 | Merck & Co., Inc. | Long lasting agonists and antagonists of LH-RH |
-
1981
- 1981-08-14 GR GR65798A patent/GR74635B/el unknown
- 1981-08-17 ES ES504791A patent/ES504791A0/es active Granted
- 1981-08-17 EP EP19810106372 patent/EP0046291B1/de not_active Expired
- 1981-08-17 DE DE8181106372T patent/DE3173304D1/de not_active Expired
- 1981-08-17 DK DK364181A patent/DK364181A/da not_active Application Discontinuation
- 1981-08-18 PT PT7353781A patent/PT73537B/pt unknown
-
1983
- 1983-01-17 ES ES519057A patent/ES519057A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
PT73537A (en) | 1981-09-01 |
PT73537B (en) | 1983-07-04 |
EP0046291A2 (de) | 1982-02-24 |
ES8403460A1 (es) | 1984-03-16 |
DK364181A (da) | 1982-02-19 |
EP0046291A3 (en) | 1982-04-14 |
EP0046291B1 (de) | 1985-12-27 |
ES8305337A1 (es) | 1983-04-01 |
ES504791A0 (es) | 1983-04-01 |
GR74635B (de) | 1984-06-29 |
ES519057A0 (es) | 1984-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |