ES8301972A1 - Procedimiento para la obtencion de n-oxidos de compuestos den-oxaciclil-alquil-piperidil-diaza - Google Patents

Procedimiento para la obtencion de n-oxidos de compuestos den-oxaciclil-alquil-piperidil-diaza

Info

Publication number
ES8301972A1
ES8301972A1 ES505410A ES505410A ES8301972A1 ES 8301972 A1 ES8301972 A1 ES 8301972A1 ES 505410 A ES505410 A ES 505410A ES 505410 A ES505410 A ES 505410A ES 8301972 A1 ES8301972 A1 ES 8301972A1
Authority
ES
Spain
Prior art keywords
compounds
oxacyclyl
oxide
preparation
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505410A
Other languages
English (en)
Other versions
ES505410A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8301972A1 publication Critical patent/ES8301972A1/es
Publication of ES505410A0 publication Critical patent/ES505410A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE N-OXIDOS DE COMPUESTOS N-OXACICLIL-ALQUIL-PIPERIDIL-DIAZA Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE R Y R SON HIDROGENO O ALQUILO INFERIOR; PH, R , R , R E Y PUEDEN SER VARIOS RADICALES; M VALE 1 A 7, Y P Y Q DE 1 A 3. CONSISTE EN LA REACCION DE OXIDACION DE UN COMPUESTO DE FORMULA (II) EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), POR TRATAMIENTO CON PERACIDOS ORGANICOS, EN PRESENCIA DE ACIDOS DE ALCANO INFERIOR, A TEMPERATURAS NO SUPERIORES A LA AMBIENTE, O CON PEROXIDO DE HIDROGENO A TEMPERATURAS NO SUPERIORES A 100<025>C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIDEPRESIVOS.
ES505410A 1980-09-12 1981-09-11 Procedimiento para la obtencion de n-oxidos de compuestos den-oxaciclil-alquil-piperidil-diaza Granted ES505410A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/186,776 US4329348A (en) 1979-02-26 1980-09-12 N-Oxacyclic-alkylpiperidines as psychostimulants

Publications (2)

Publication Number Publication Date
ES8301972A1 true ES8301972A1 (es) 1983-01-01
ES505410A0 ES505410A0 (es) 1983-01-01

Family

ID=22686246

Family Applications (1)

Application Number Title Priority Date Filing Date
ES505410A Granted ES505410A0 (es) 1980-09-12 1981-09-11 Procedimiento para la obtencion de n-oxidos de compuestos den-oxaciclil-alquil-piperidil-diaza

Country Status (13)

Country Link
US (1) US4329348A (es)
EP (1) EP0048218A1 (es)
JP (1) JPS5781483A (es)
AU (1) AU7516881A (es)
DD (1) DD202292A5 (es)
DK (1) DK405981A (es)
ES (1) ES505410A0 (es)
FI (1) FI812811L (es)
GB (1) GB2083813A (es)
IL (1) IL63789A0 (es)
NO (1) NO813110L (es)
PT (1) PT73657B (es)
ZA (1) ZA816322B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3124366A1 (de) * 1981-06-20 1982-12-30 Hoechst Ag, 6000 Frankfurt N-oxacyclyl-alkylpiperidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und deren verwendung
FR2579596B1 (fr) * 1985-03-26 1987-11-20 Inst Nat Sante Rech Med (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique
US4957928A (en) * 1986-06-26 1990-09-18 Ciba-Geigy Corporation Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
JP3916092B2 (ja) * 1993-09-17 2007-05-16 杏林製薬株式会社 イミダゾリジノン誘導体とその酸付加塩及び老年性痴呆症の治療薬
US6133277A (en) * 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
UA73123C2 (en) 1999-06-02 2005-06-15 Janssen Pharmaceutica Nv Derivatives of benzodioxane, benzofuran or benzopyran substituted by pyrolidinyl, piperidinyl or homopiperidinyl
IL146840A0 (en) 1999-06-02 2002-07-25 Janssen Pharmaceutica Nv Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en) * 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) * 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
US6540733B2 (en) * 2000-12-29 2003-04-01 Corazon Technologies, Inc. Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion
US20070004736A1 (en) * 2002-11-22 2007-01-04 Keiji Kubo Imidazole derivative, process for producing the same, and use
TWI396686B (zh) * 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
GB0526042D0 (en) * 2005-12-21 2006-02-01 Syngenta Participations Ag Chemical compounds
TWI457122B (zh) * 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3513239A (en) * 1967-03-15 1970-05-19 Smithkline Corp Pharmaceutical compositions containing 2-aminoalkyl coumaran derivatives and methods of treating depression therewith
US3629267A (en) * 1968-10-28 1971-12-21 Smith Kline French Lab Benzoheterocyclicalkyl derivatives of 4-(2-keto -1-benzimidazolinyl)-piperidine 4-(2-keto - 1 - benzimidazolinyl) -1 2 3 6 tetrahydropyridine 1 - phenyl - 1 3 8-triazaspiro(4 5)decan - 4 - one and 2 4 9-triazaspiro(5 5)undecan-1 3 5-trione
BE794333A (fr) 1972-01-20 1973-07-19 Wyeth John & Brother Ltd Composes heterocycliques azotes therapeutiques
US3910930A (en) * 1973-01-04 1975-10-07 Janssen Pharmaceutica Nv 1-{55 1-{8 2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl{9 -4-piperidyl{56 -2-benzimidazolinones
US3869463A (en) * 1973-01-17 1975-03-04 Wyeth John & Brother Ltd N-phenyl derivatives of alkanoylamido piperidines
US3929801A (en) * 1973-11-20 1975-12-30 Janssen Pharmaceutica Nv 2-Benzimidazolinones
ZA76475B (en) * 1975-03-10 1977-08-31 Ciba Geigy Ag Indolyalkylpiperidines
US4147786A (en) * 1976-02-02 1979-04-03 Ciba-Geigy Corporation 1-Indolylalkyl-3-or 4-trimethyleneurido-piperidines
GB1582239A (en) * 1976-12-11 1981-01-07 Wyeth John & Brother Ltd Piperidin-4-yl ureas and thioureas
GR71865B (es) 1978-03-20 1983-07-07 Ciba Geigy
DE2852945A1 (de) 1978-12-07 1980-06-26 Boehringer Sohn Ingelheim Benzodioxanyl-hydroxyaethylpiperidyl- imidazolidinone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
DD202292A5 (de) 1983-09-07
ES505410A0 (es) 1983-01-01
IL63789A0 (en) 1981-12-31
JPS5781483A (en) 1982-05-21
AU7516881A (en) 1982-03-18
US4329348A (en) 1982-05-11
PT73657A (en) 1981-10-01
PT73657B (en) 1983-10-20
DK405981A (da) 1982-03-13
FI812811L (fi) 1982-03-13
EP0048218A1 (de) 1982-03-24
GB2083813A (en) 1982-03-31
ZA816322B (en) 1982-09-29
NO813110L (no) 1982-03-15

Similar Documents

Publication Publication Date Title
ES8301972A1 (es) Procedimiento para la obtencion de n-oxidos de compuestos den-oxaciclil-alquil-piperidil-diaza
ES8306141A1 (es) Un procedimiento para la produccion de un derivado de carbostirilo
ES8405398A1 (es) Procedimiento para preparar nuevos diazabiciclo-(3.3.1)-nonanos
HUT36113A (en) Process for preparing dihydro-pyridibes with anti-ischaemic activity and blood pressure decreasing effect and pharmaceutical compositions containing such compounds
ES484570A1 (es) Procedimiento para la obtencion de compuestos de n-oxaciclil-alquil-piperidil-diaza
IL83871A (en) Naphthyl derivatives,their preparation and pharmaceutical compositions containing them
ES8400403A1 (es) &#34;procedimiento para la preparacion de compuestos de 1-fenil-2-aminocarbonilindol&#34;.
ES8403098A1 (es) Un procedimiento para la preparacion de derivados de etanolamina.
ES8205791A1 (es) Procedimiento para la preparacion de derivados de imidazol del sistema de 1,4-benzodioxan-2-ilo
ES8701760A1 (es) Procedimiento para preparar imidazo (1,2-c)pirimidinas
ES8301882A1 (es) Un procedimiento para la preparacion de un derivado de fene-tilamina
ES8402839A1 (es) Procedimiento para la obtencion de nuevos poliazaheterociclicos policiclicos.
ES8400743A1 (es) &#34;procedimiento para la preparacion de compuestos de 1-fenilindazol-3-ona&#34;.
EP0173377A3 (en) Pyrimidone compounds, their preparation and pharmaceutical compositions containing them
IL73696A (en) N-(benzazepin-3-yl)-and n-(benzodiazepin-3-yl)-alkylene-n-indol-3-yl-alkylene-amine derivatives,their preparation and pharmaceutical compositions containing them
IL79785A0 (en) Tetraoxo compounds,their preparation and pharmaceutical compositions containing them
ES8304098A1 (es) Un procedimiento para la preparacion de nuevos derivados de dibenzoxazonina, dibenzoxazelina o dibenzooxaazacicloundeca-no y sus correspondientes derivados tia y aza.
ES8205413A1 (es) Procedimiento para preparar nuevas benzotiopirano (2,3-c)pi-ridinas
ATE28859T1 (de) Derivate von aminonaphthacen und verfahren zu ihrer herstellung.
ES8402821A1 (es) Procedimiento de obtencion de las feniloxoalcoil piperidinas.
TH1594A (th) สารประกอบไทรไซคลิค