ES8301882A1 - Un procedimiento para la preparacion de un derivado de fene-tilamina - Google Patents
Un procedimiento para la preparacion de un derivado de fene-tilaminaInfo
- Publication number
- ES8301882A1 ES8301882A1 ES504376A ES504376A ES8301882A1 ES 8301882 A1 ES8301882 A1 ES 8301882A1 ES 504376 A ES504376 A ES 504376A ES 504376 A ES504376 A ES 504376A ES 8301882 A1 ES8301882 A1 ES 8301882A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- hydrogen atom
- lower alkyl
- alkyl group
- represents hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- BHHGXPLMPWCGHP-UHFFFAOYSA-N Phenethylamine Chemical class NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE UN DERIVADO DE FENETILAMINA, DE FORMULA (I), EN LA QUE R ES ALQUILO INFERIOR; R ES ALQUILO O ALCOXI INFERIORES; R Y R SON HIDROGENO O ALQUILO INFERIOR; R ES HIDROGENO O ALCOXI INFERIOR; X ES OXIGENO O METILENO; Y M Y N VALEN 1-3 Y 0-2, RESPECTIVAMENTE. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), CON UNA AMINA DE FORMULA (III), EN LAS QUE W ES UN RADICAL DE FORMULA (IV) O (V); Z ES HIDROGENO O BENICLO; HAL ES HALOGENO; Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE, A LA TEMPERATURA DE REFLUJO DE LA MEZCLA DE REACCION. ESTOS COMPUESTOS TIENE APLICACIONES FARMACOLOGICAS COMO AGENTES HIPERTENSIVOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10417580A JPS5728040A (en) | 1980-07-29 | 1980-07-29 | Phenylethanolamine derivative |
JP9201081A JPS57206652A (en) | 1981-06-15 | 1981-06-15 | Substituted phenyl ether derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
ES504376A0 ES504376A0 (es) | 1982-12-16 |
ES8301882A1 true ES8301882A1 (es) | 1982-12-16 |
Family
ID=26433470
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES504376A Expired ES8301882A1 (es) | 1980-07-29 | 1981-07-28 | Un procedimiento para la preparacion de un derivado de fene-tilamina |
Country Status (7)
Country | Link |
---|---|
US (2) | US4880841A (es) |
CA (1) | CA1224494A (es) |
DE (1) | DE3128117A1 (es) |
ES (1) | ES8301882A1 (es) |
FR (1) | FR2487827A1 (es) |
GB (1) | GB2083022B (es) |
IT (1) | IT1172230B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5198587A (en) * | 1980-07-29 | 1993-03-30 | Yamanouchi Pharmaceutical Co., Ltd. | Phenethylamine derivatives |
JPS6341451A (ja) * | 1986-08-06 | 1988-02-22 | Nippon Kayaku Co Ltd | エ−テル誘導体およびそれを有効成分とする殺ダニ、殺虫組成物 |
WO1999057131A1 (en) * | 1998-05-06 | 1999-11-11 | Duke University | Method of treating bladder and lower urinary tract syndromes |
WO2005056521A1 (en) * | 2003-12-09 | 2005-06-23 | Cj Corporation | Method of preparing optically pure phenethylamine derivatives |
CN102050766B (zh) * | 2009-11-03 | 2013-08-07 | 安徽省新星药物开发有限责任公司 | 一种盐酸氨磺洛尔的合成方法 |
WO2020112855A1 (en) * | 2018-11-29 | 2020-06-04 | Reform Biologics, Llc | Excipient compounds for protein processing |
US10478498B2 (en) | 2014-06-20 | 2019-11-19 | Reform Biologics, Llc | Excipient compounds for biopolymer formulations |
US20160074515A1 (en) | 2014-06-20 | 2016-03-17 | Reform Biologics, Llc | Viscosity-reducing excipient compounds for protein formulations |
US11357857B2 (en) | 2014-06-20 | 2022-06-14 | Comera Life Sciences, Inc. | Excipient compounds for protein processing |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1543372A1 (de) * | 1966-10-18 | 1971-04-01 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von o-substituierten 3,4-Dioxyphenylalkanolaminen |
GB1321701A (en) * | 1969-10-01 | 1973-06-27 | Continental Pharma | Amino-alcohols their salts and process for prepairing the same |
US4137328A (en) * | 1970-07-18 | 1979-01-30 | Pfizer Inc. | Phenyl-alkanolamine, alkylamine and α-aminoalkyl ketone derivatives as heart stimulants |
GB1390748A (en) * | 1973-04-09 | 1975-04-16 | Continental Pharma | Alkyl and cycloalkylthiophenylalkylaminoalkanols their salts and the preparation thereof |
US4048229A (en) * | 1975-01-08 | 1977-09-13 | Smithkline Corporation | α-AMINOMETHYL-4-HYDROXY-3-METHYLSULFONYL BENZYL ALCOHOLS |
US4119729A (en) * | 1975-12-19 | 1978-10-10 | Mead Johnson & Company | Alkylsulfonylphenoxypropanolamine therapeutic process |
US4695589A (en) * | 1976-06-25 | 1987-09-22 | Sterling Drug Inc. | Alpha-(aminoalkyl-4-hydroxy-3-(alkylthio)benzenemethanols |
US4327224A (en) * | 1976-06-25 | 1982-04-27 | Sterling Drug Inc. | α-[(alkylamino)alkyl]-4-hydroxy-3-(alkylthio)benzenemethanols, derivatives thereof and intermediates therefor |
GB1544872A (en) * | 1976-06-25 | 1979-04-25 | Sterling Drug Inc | 4-hydroxyphenylalkanolamine derivatives and preparation thereof |
US4374149A (en) * | 1977-06-03 | 1983-02-15 | Sterling Drug Inc. | α-{[(Arylalkyl)amino]alkyl}-4-hydroxy-3-(lower-alkylsulfinyl)benzenemethanols |
JPS552639A (en) * | 1978-06-21 | 1980-01-10 | Yamanouchi Pharmaceut Co Ltd | Phenylethanolamine derivative and its preparation |
CA1147342A (en) * | 1977-10-12 | 1983-05-31 | Kazuo Imai | Process of producing novel phenylethanolamine derivatives |
LU79970A1 (fr) * | 1978-07-13 | 1980-02-14 | Continental Pharma | Procede de preparation de derives de 1-phenyl-1-propanol |
US4304790A (en) * | 1979-06-12 | 1981-12-08 | Schering Corporation | 2-(Alkylthio, alkylsulfinyl or alkylsulfonyl)-4-[2-anilinoalkylamino)-1-hydroxyethyl]phenols and derivatives thereof |
EP0040000B1 (en) * | 1980-05-08 | 1983-10-12 | Beecham Group Plc | Arylethanolamine derivatives, their preparation and use in pharmaceutical compositions |
US4379166A (en) * | 1981-08-03 | 1983-04-05 | Schering Corporation | Arylmethoxy-, arylmethylthio-, heteroarylmethoxy-, and heteroarylmethylthio-alkylaminoalcohols |
US4720586A (en) * | 1983-12-06 | 1988-01-19 | Fisons, Plc | Substituted 3,4-dihydroxy-phenylethylamino compounds |
-
1981
- 1981-07-16 DE DE19813128117 patent/DE3128117A1/de not_active Ceased
- 1981-07-23 GB GB8122797A patent/GB2083022B/en not_active Expired
- 1981-07-27 CA CA000382575A patent/CA1224494A/en not_active Expired
- 1981-07-28 IT IT68052/81A patent/IT1172230B/it active
- 1981-07-28 ES ES504376A patent/ES8301882A1/es not_active Expired
- 1981-07-29 FR FR8114716A patent/FR2487827A1/fr active Granted
-
1989
- 1989-02-03 US US07/307,200 patent/US4880841A/en not_active Expired - Fee Related
-
1990
- 1990-08-21 US US07/569,780 patent/US5063246A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2487827A1 (fr) | 1982-02-05 |
IT1172230B (it) | 1987-06-18 |
GB2083022A (en) | 1982-03-17 |
US4880841A (en) | 1989-11-14 |
ES504376A0 (es) | 1982-12-16 |
US5063246A (en) | 1991-11-05 |
GB2083022B (en) | 1984-09-12 |
IT8168052A0 (it) | 1981-07-28 |
FR2487827B1 (es) | 1985-04-19 |
CA1224494A (en) | 1987-07-21 |
DE3128117A1 (de) | 1982-03-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970303 |