JPS57206652A - Substituted phenyl ether derivative - Google Patents

Substituted phenyl ether derivative

Info

Publication number
JPS57206652A
JPS57206652A JP9201081A JP9201081A JPS57206652A JP S57206652 A JPS57206652 A JP S57206652A JP 9201081 A JP9201081 A JP 9201081A JP 9201081 A JP9201081 A JP 9201081A JP S57206652 A JPS57206652 A JP S57206652A
Authority
JP
Japan
Prior art keywords
compound
formula
substituted phenyl
phenyl ether
ether derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9201081A
Other languages
Japanese (ja)
Other versions
JPH0255418B2 (en
Inventor
Kunihiro Niigata
Takashi Fujikura
Kazuo Imai
Shinichi Hashimoto
Kazuo Honda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP9201081A priority Critical patent/JPS57206652A/en
Priority to DE19813128117 priority patent/DE3128117A1/en
Priority to GB8122797A priority patent/GB2083022B/en
Priority to CA000382575A priority patent/CA1224494A/en
Priority to IT68052/81A priority patent/IT1172230B/en
Priority to ES504376A priority patent/ES504376A0/en
Priority to FR8114716A priority patent/FR2487827A1/en
Priority to ES514426A priority patent/ES514426A0/en
Publication of JPS57206652A publication Critical patent/JPS57206652A/en
Priority to US07/307,200 priority patent/US4880841A/en
Priority to US07/569,780 priority patent/US5063246A/en
Publication of JPH0255418B2 publication Critical patent/JPH0255418B2/ja
Priority to US07/737,976 priority patent/US5198587A/en
Granted legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

NEW MATERIAL:The compound of formulaI(R1, R2, R3 and R4 are H or lower alkyl; X is O or methylene; m is 1W3; n is 0W2).
EXAMPLE: 4-{2-[2-( 2-Methoxyphenoxy )ethylamino]-2-methylethyl}-2-(methylthio)phenetole.
USE: It has α-adrenaline receptor blocking activity, and is useful as a hypotensor.
PROCESS: The ketone of formula II is condensed with the amine of formula III by heating in an organic solvent such as methanol to obtain the compound of formula IV. If necessary after separating the compound from the reaction mixture, the product is reduced either by contacting with H2 in the presence of a catalyst such as platinum oxide or by using a reducing agent such as NaBH4 to obtain the objective compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP9201081A 1980-07-29 1981-06-15 Substituted phenyl ether derivative Granted JPS57206652A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP9201081A JPS57206652A (en) 1981-06-15 1981-06-15 Substituted phenyl ether derivative
DE19813128117 DE3128117A1 (en) 1980-07-29 1981-07-16 NEW PHENYL-AETHYLAMINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF
GB8122797A GB2083022B (en) 1980-07-29 1981-07-23 Phenethylamine derivatives and their production
CA000382575A CA1224494A (en) 1980-07-29 1981-07-27 Process of producing novel phenethylamine derivatives
ES504376A ES504376A0 (en) 1980-07-29 1981-07-28 A PROCEDURE FOR THE PREPARATION OF A FENE-TILAMINE DERIVATIVE
IT68052/81A IT1172230B (en) 1980-07-29 1981-07-28 PHENETHYLAMINE DERIVATIVES AND PROCEDURE FOR THEIR PRODUCTION
FR8114716A FR2487827A1 (en) 1980-07-29 1981-07-29 NOVEL DERIVATIVES OF PHENETYLAMINE AND PROCESS FOR THEIR PRODUCTION
ES514426A ES514426A0 (en) 1981-06-15 1982-07-27 A PROCEDURE FOR THE PREPARATION OF A FENETILAMINA DERIVATIVE.
US07/307,200 US4880841A (en) 1980-07-29 1989-02-03 Process of producing phenethylamine derivatives
US07/569,780 US5063246A (en) 1980-07-29 1990-08-21 Phenethylamine derivative compositions and use
US07/737,976 US5198587A (en) 1980-07-29 1991-07-30 Phenethylamine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9201081A JPS57206652A (en) 1981-06-15 1981-06-15 Substituted phenyl ether derivative

Publications (2)

Publication Number Publication Date
JPS57206652A true JPS57206652A (en) 1982-12-18
JPH0255418B2 JPH0255418B2 (en) 1990-11-27

Family

ID=14042505

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9201081A Granted JPS57206652A (en) 1980-07-29 1981-06-15 Substituted phenyl ether derivative

Country Status (2)

Country Link
JP (1) JPS57206652A (en)
ES (1) ES514426A0 (en)

Also Published As

Publication number Publication date
ES8306084A1 (en) 1983-05-01
ES514426A0 (en) 1983-05-01
JPH0255418B2 (en) 1990-11-27

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