ES8701760A1 - Procedimiento para preparar imidazo (1,2-c)pirimidinas - Google Patents

Procedimiento para preparar imidazo (1,2-c)pirimidinas

Info

Publication number
ES8701760A1
ES8701760A1 ES550003A ES550003A ES8701760A1 ES 8701760 A1 ES8701760 A1 ES 8701760A1 ES 550003 A ES550003 A ES 550003A ES 550003 A ES550003 A ES 550003A ES 8701760 A1 ES8701760 A1 ES 8701760A1
Authority
ES
Spain
Prior art keywords
carbon atoms
pyrimidines
group
imidazo
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES550003A
Other languages
English (en)
Other versions
ES550003A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES8701760A1 publication Critical patent/ES8701760A1/es
Publication of ES550003A0 publication Critical patent/ES550003A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Pens And Brushes (AREA)
  • Dental Preparations (AREA)
  • Luminescent Compositions (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE IMIDAZO1,2-CPIRIMIDINAS. COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) EN PRESENCIA DE UN DISOLVENTE ORGANICO COMO EL TETRAHIDROFURANO, ETER ETILICO O DIMETOXIETANO PARA DAR UN COMPUESTO DE FORMULA (VI); B) CICLAR EL COMPUESTO DE FORMULA (VI) SOMETIENDOLO A REFLUJO EN UN DISOLVENTE ADECUADO COMO UN ALCANOL INFERIOR, A TEMPERATURA SUPERIOR A 70JC, PARA DAR UN COMPUESTO DE FORMULA (IC). SIENDO: R UN GRUPO ARILO C6-12; RL1 UN ATOMO DE H O UN GRUPO ALQUILO C1-5, ALCOXI1-5 O ALQUILTIO; R4 UN GRUPO ALCOXI C1-5 O ALQUILTIO; R5 UN ATOMO DE H O UN GRUPO ALQUILO C1-5; Y X PREFERENTEMENTE UN ATOMO DE BROMO. SE UTILIZAN COMO FARMACOS EN TERAPIA ANSIOLITICA DEL SER HUMANO O ANIMAL.
ES550003A 1983-12-22 1985-12-16 Procedimiento para preparar imidazo (1,2-c)pirimidinas Expired ES8701760A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838334210A GB8334210D0 (en) 1983-12-22 1983-12-22 Imidazo(1 2-c)pyrimidines

Publications (2)

Publication Number Publication Date
ES8701760A1 true ES8701760A1 (es) 1986-12-01
ES550003A0 ES550003A0 (es) 1986-12-01

Family

ID=10553694

Family Applications (2)

Application Number Title Priority Date Filing Date
ES538933A Expired ES8605521A1 (es) 1983-12-22 1984-12-21 Un procedimiento para preparar imidazo(1,2-c)pirimidinas
ES550003A Expired ES8701760A1 (es) 1983-12-22 1985-12-16 Procedimiento para preparar imidazo (1,2-c)pirimidinas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES538933A Expired ES8605521A1 (es) 1983-12-22 1984-12-21 Un procedimiento para preparar imidazo(1,2-c)pirimidinas

Country Status (17)

Country Link
US (1) US4643999A (es)
EP (1) EP0147312B1 (es)
JP (1) JPS60169479A (es)
KR (1) KR850004763A (es)
AT (1) ATE42292T1 (es)
AU (1) AU565745B2 (es)
CA (1) CA1233175A (es)
DE (1) DE3477782D1 (es)
DK (1) DK605484A (es)
ES (2) ES8605521A1 (es)
FI (1) FI78099C (es)
GB (2) GB8334210D0 (es)
GR (1) GR82546B (es)
HU (1) HU192653B (es)
NZ (1) NZ210715A (es)
PT (1) PT79732B (es)
ZA (1) ZA849553B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3638121A1 (de) * 1986-05-30 1987-12-03 Bayer Ag 1,2,3,6-tetrahydro-5-nitro-pyrimidin-derivate
US4873251A (en) * 1986-06-09 1989-10-10 A. H. Robins Company, Incorporated Method of treating animals using fused imidazoheterocyclic compounds
GB8620060D0 (en) * 1986-08-18 1986-10-01 Roussel Lab Ltd Chemical compounds
US5095015A (en) * 1990-07-24 1992-03-10 Neurogen Corporation Certain azacycloalkyl imidazopyrimidines; a new class of gaba brain receptor ligands
US5185446A (en) * 1990-09-04 1993-02-09 Neurogen Corporation Certain cycloalkyl imidazopyrimidines; a new class of gaba brainreceptor ligands
GB0125278D0 (en) * 2001-10-20 2001-12-12 Cutts Dennis Small bore pipe splitter for underground use
CA2820262A1 (en) 2010-12-08 2012-06-14 Vanderbilt University Bicyclic pyrazole compounds as allosteric modulators of mglur5 receptors
US8865725B2 (en) 2011-03-15 2014-10-21 Vanderbilt University Substituted imidazopyrimidin-5(6H)-ones as allosteric modulators of MGLUR5 receptors
WO2012125732A1 (en) * 2011-03-15 2012-09-20 Vanderbilt University Substituted imadazapyrinidin-5(6h)-ones as allosteric modulators of mglur5 receptors
GB201401198D0 (en) 2014-01-24 2014-03-12 Bial Portela & Ca Sa Process for the syntheis of substituted urea compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS523957B2 (es) * 1974-03-14 1977-01-31
US4223031A (en) * 1978-05-05 1980-09-16 Mead Johnson & Company Azolopyrimidinones
FR2473522A1 (fr) * 1980-01-16 1981-07-17 Synthelabo Nouveaux derives substitues de dihydro-2,3 imidazo(1,2-b)pyridazines et les medicaments, utiles notamment comme antidepresseurs, qui en contiennent
FR2502622A1 (fr) * 1981-03-25 1982-10-01 Synthelabo Derives d'imidazo (1,2-a) pyrimidines, leur preparation et leur application en therapeutique
IL69417A (en) * 1982-08-27 1987-12-20 Roussel Uclaf 2-acyl imidazo(1,2-a)pyrimidines,their preparation and pharmaceutical compositions containing them
US4521422A (en) * 1983-06-23 1985-06-04 American Cyanamid Company Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones

Also Published As

Publication number Publication date
PT79732A (en) 1985-01-01
EP0147312A2 (fr) 1985-07-03
AU3697784A (en) 1985-07-04
ES8605521A1 (es) 1986-03-16
FI845102L (fi) 1985-06-23
NZ210715A (en) 1987-05-29
FI78099B (fi) 1989-02-28
DE3477782D1 (en) 1989-05-24
GB2151624B (en) 1987-11-11
ES538933A0 (es) 1986-03-16
CA1233175A (en) 1988-02-23
HUT37431A (en) 1985-12-28
US4643999A (en) 1987-02-17
DK605484A (da) 1985-06-23
PT79732B (en) 1986-12-30
AU565745B2 (en) 1987-09-24
EP0147312B1 (fr) 1989-04-19
KR850004763A (ko) 1985-07-27
GR82546B (en) 1985-04-08
FI78099C (fi) 1989-06-12
GB8432343D0 (en) 1985-02-06
ZA849553B (en) 1986-01-29
EP0147312A3 (en) 1986-04-30
GB8334210D0 (en) 1984-02-01
ATE42292T1 (de) 1989-05-15
ES550003A0 (es) 1986-12-01
GB2151624A (en) 1985-07-24
JPS60169479A (ja) 1985-09-02
FI845102A0 (fi) 1984-12-21
HU192653B (en) 1987-06-29
DK605484D0 (da) 1984-12-18

Similar Documents

Publication Publication Date Title
IL62110A (en) Pharmaceutical compositions containing(substituted)phenyl alkyl imidazole derivatives,some new such compounds and their preparation
ES8505518A1 (es) Procedimiento para preparar derivados de aminoacidos
ES8605521A1 (es) Un procedimiento para preparar imidazo(1,2-c)pirimidinas
ES8505922A1 (es) Procedimiento para preparar nuevos derivados del acido 4-fenil-4-oxo-buten-2-oico
ES8201140A1 (es) Procedimiento para la preparacion de 2-fenilamino-imidazoli nas-(2)sustituidas.
EP0305298A3 (en) Imidazobenzodiazepines and their acid addition salts, process and intermediates for their preparation, their use as medicaments and compositions containing them
ES8703861A1 (es) Un procedimiento para preparar nuevas 1,2,4-tiadiazinas
ES8105319A1 (es) Procedimiento de preparacion de derivados pirazolo (1,5-c) quinazolinos y de sus sales de adicion acidas
ES8403891A1 (es) Un procedimiento para la preparacion de un derivado del acido furiloxazolila-cetico
ES8205413A1 (es) Procedimiento para preparar nuevas benzotiopirano (2,3-c)pi-ridinas
ES8607944A1 (es) Procedimiento para la preparacion de nuevos derivados de 1- fenilimidazolidin-2-ona
ES8201135A1 (es) Un procedimiento para preparar derivados de cicloheptilindo-lol
ZA838139B (en) Semicarbazides,process for preparing these,and pharmaceutical compositions thereof