IE830186L - Purines - Google Patents

Purines

Info

Publication number
IE830186L
IE830186L IE18683A IE18683A IE830186L IE 830186 L IE830186 L IE 830186L IE 18683 A IE18683 A IE 18683A IE 18683 A IE18683 A IE 18683A IE 830186 L IE830186 L IE 830186L
Authority
IE
Ireland
Prior art keywords
cor8
adamantyl
alkyl
formula
new
Prior art date
Application number
IE18683A
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of IE830186L publication Critical patent/IE830186L/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

EP--85424 A (A) 9-(2-acyloxy-1-hydroxymethyl ethoxymethyl) purine derivs. of formula (I) and their acid-addn. salts are new, (R1 is H or R7CO; R7 is H, 1-19C alkyl, 1-8C hydroxyalkyl, 2-9C alkoxyalkyl, 2-19C alkenyl, Ph, 1-adamantyl, 2-carboxyethyl, or carboxymethyl or their alkali metal salts; R2 is R7CO; R3 is H, halogen, SH, 1-6C alkylthio, N3, NR9R19 or NH-COR8; R8 is H, 1-19C alkyl or 1-adamantyl; R9 and R10 are H or 1-6C alkyl; and either (a) R4+R5 form a single bond and R6 is H, halogen, 1-6C alkoxy, N3, SH, 1-6C alkylthio, NR9R10 or NH-COR8; or (b) R4 is H and R5+R6 form a keto group). (B) Intermediates of formula (I) are new when (1) R1 and R2 are H; R3 is other than NY-COR8; R4 and R5 form a bond and R6 is other than NH-COR8; and (2) R1, R2 and R4 are H; R3 is NH-COR8; and R5+R6 form a keto gp. - Cpds. (I) are antivirals esp. effective against Herpes simplex virus I and II, cytomegalovirus, Epstein-Barr virus and varicella zoster virus and viral hepatitis B. Intermediates defined in paragraph (B) are also antivirals. Dose is 0.1-300 mg/kg. orally or parenterally. (0/0) USAB- US4612314 A Substd. 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines of formula (I) are new. In (I), R1 and R2 are both -C(O)R7 in which R7 is 1-adamantyl; R3 is NH2 a R6 is H or NH2 and R4 with R5 is a bond or b R5 with R6 is keto and R4 is H. Esp. cpd. is 9-(1,3-di(1-adamantyl carboxy)-2-propoxy methyl)guanine. (I) may be prepd. e.g. by esterifying cpds. (X) and (IV). [ES8601991A1]
IE18683A 1982-02-01 1983-01-31 Purines IE830186L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34470382A 1982-02-01 1982-02-01

Publications (1)

Publication Number Publication Date
IE830186L true IE830186L (en) 1983-08-01

Family

ID=23351643

Family Applications (1)

Application Number Title Priority Date Filing Date
IE18683A IE830186L (en) 1982-02-01 1983-01-31 Purines

Country Status (6)

Country Link
JP (1) JPS58135885A (en)
ES (2) ES532109A0 (en)
IE (1) IE830186L (en)
PL (1) PL143974B1 (en)
SU (3) SU1537138A3 (en)
ZA (1) ZA83626B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
DE3376325D1 (en) * 1982-10-14 1988-05-26 Wellcome Found Antiviral purine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
KR880002276B1 (en) * 1981-08-11 1988-10-21 더 웰컴 화운데이션 리미티드 Process for preparation of anti viral compounds
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation

Also Published As

Publication number Publication date
ES8601991A1 (en) 1985-12-01
ES532108A0 (en) 1985-12-01
SU1553013A3 (en) 1990-03-23
ES8505680A1 (en) 1985-06-16
ES532109A0 (en) 1985-06-16
PL143974B1 (en) 1988-03-31
PL253590A1 (en) 1986-02-11
ZA83626B (en) 1983-12-28
SU1553012A3 (en) 1990-03-23
SU1537138A3 (en) 1990-01-15
JPS58135885A (en) 1983-08-12

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