ES8505680A1 - Substituted purine, manufacture and antiviral - Google Patents
Substituted purine, manufacture and antiviralInfo
- Publication number
- ES8505680A1 ES8505680A1 ES532109A ES532109A ES8505680A1 ES 8505680 A1 ES8505680 A1 ES 8505680A1 ES 532109 A ES532109 A ES 532109A ES 532109 A ES532109 A ES 532109A ES 8505680 A1 ES8505680 A1 ES 8505680A1
- Authority
- ES
- Spain
- Prior art keywords
- cor8
- adamantyl
- alkyl
- formula
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Abstract
EP--85424 A (A) 9-(2-acyloxy-1-hydroxymethyl ethoxymethyl) purine derivs. of formula (I) and their acid-addn. salts are new, (R1 is H or R7CO R7 is H, 1-19C alkyl, 1-8C hydroxyalkyl, 2-9C alkoxyalkyl, 2-19C alkenyl, Ph, 1-adamantyl, 2-carboxyethyl, or carboxymethyl or their alkali metal salts R2 is R7CO R3 is H, halogen, SH, 1-6C alkylthio, N3, NR9R19 or NH-COR8 R8 is H, 1-19C alkyl or 1-adamantyl R9 and R10 are H or 1-6C alkyl and either (a) R4+R5 form a single bond and R6 is H, halogen, 1-6C alkoxy, N3, SH, 1-6C alkylthio, NR9R10 or NH-COR8 or (b) R4 is H and R5+R6 form a keto group). (B) Intermediates of formula (I) are new when (1) R1 and R2 are H R3 is other than NY-COR8 R4 and R5 form a bond and R6 is other than NH-COR8 and (2) R1, R2 and R4 are H R3 is NH-COR8 and R5+R6 form a keto gp. - Cpds. (I) are antivirals esp. effective against Herpes simplex virus I and II, cytomegalovirus, Epstein-Barr virus and varicella zoster virus and viral hepatitis B. Intermediates defined in paragraph (B) are also antivirals. Dose is 0.1-300 mg/kg. orally or parenterally. (0/0) USAB- US4612314 A Substd. 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines of formula (I) are new. In (I), R1 and R2 are both -C(O)R7 in which R7 is 1-adamantyl R3 is NH2 a R6 is H or NH2 and R4 with R5 is a bond or b R5 with R6 is keto and R4 is H. Esp. cpd. is 9-(1,3-di(1-adamantyl carboxy)-2-propoxy methyl)guanine. (I) may be prepd. e.g. by esterifying cpds. (X) and (IV).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34470382A | 1982-02-01 | 1982-02-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES532109A0 ES532109A0 (en) | 1985-06-16 |
| ES8505680A1 true ES8505680A1 (en) | 1985-06-16 |
Family
ID=23351643
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES532109A Expired ES8505680A1 (en) | 1982-02-01 | 1984-05-02 | Substituted purine, manufacture and antiviral |
| ES532108A Expired ES8601991A1 (en) | 1982-02-01 | 1984-05-02 | Substituted purine, manufacture and antiviral |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES532108A Expired ES8601991A1 (en) | 1982-02-01 | 1984-05-02 | Substituted purine, manufacture and antiviral |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS58135885A (en) |
| ES (2) | ES8505680A1 (en) |
| IE (1) | IE830186L (en) |
| PL (1) | PL143974B1 (en) |
| SU (3) | SU1537138A3 (en) |
| ZA (1) | ZA83626B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ201662A (en) * | 1981-08-26 | 1986-07-11 | Merck & Co Inc | 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation |
| FI74468C (en) * | 1982-10-14 | 1988-02-08 | Wellcome Found | FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT AKTIVA 2-AMINOPURINDERIVAT. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4355032B2 (en) * | 1981-05-21 | 1990-10-30 | 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent | |
| EP0072027B1 (en) * | 1981-08-11 | 1988-05-18 | The Wellcome Foundation Limited | Antiviral compounds |
| NZ201662A (en) * | 1981-08-26 | 1986-07-11 | Merck & Co Inc | 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation |
-
1983
- 1983-01-31 ZA ZA83626A patent/ZA83626B/en unknown
- 1983-01-31 PL PL25359083A patent/PL143974B1/en unknown
- 1983-01-31 IE IE18683A patent/IE830186L/en unknown
- 1983-01-31 SU SU833549200A patent/SU1537138A3/en active
- 1983-01-31 JP JP1539483A patent/JPS58135885A/en active Pending
-
1984
- 1984-05-02 ES ES532109A patent/ES8505680A1/en not_active Expired
- 1984-05-02 ES ES532108A patent/ES8601991A1/en not_active Expired
- 1984-12-17 SU SU843829109A patent/SU1553013A3/en active
- 1984-12-17 SU SU843828798A patent/SU1553012A3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| ES532108A0 (en) | 1985-12-01 |
| ZA83626B (en) | 1983-12-28 |
| SU1553013A3 (en) | 1990-03-23 |
| PL143974B1 (en) | 1988-03-31 |
| ES532109A0 (en) | 1985-06-16 |
| ES8601991A1 (en) | 1985-12-01 |
| SU1537138A3 (en) | 1990-01-15 |
| JPS58135885A (en) | 1983-08-12 |
| PL253590A1 (en) | 1986-02-11 |
| IE830186L (en) | 1983-08-01 |
| SU1553012A3 (en) | 1990-03-23 |
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