AU2002212734A1 - Amide derivatives - Google Patents

Amide derivatives

Info

Publication number
AU2002212734A1
AU2002212734A1 AU2002212734A AU1273402A AU2002212734A1 AU 2002212734 A1 AU2002212734 A1 AU 2002212734A1 AU 2002212734 A AU2002212734 A AU 2002212734A AU 1273402 A AU1273402 A AU 1273402A AU 2002212734 A1 AU2002212734 A1 AU 2002212734A1
Authority
AU
Australia
Prior art keywords
accompanied
amide derivative
infection
herpes
hsv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002212734A
Inventor
Wataru Hamaguchi
Shunji Kageyama
Toru Kontani
Junji Miyata
Yoji Miyazaki
Ei-Ichi Nakai
Hiroshi Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
RATIONAL DRUG DESIGN LAB
Astellas Pharma Inc
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RATIONAL DRUG DESIGN LAB, Astellas Pharma Inc, Yamanouchi Pharmaceutical Co Ltd filed Critical RATIONAL DRUG DESIGN LAB
Publication of AU2002212734A1 publication Critical patent/AU2002212734A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/74—Sulfur atoms substituted by carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

The invention relates to a novel amide derivative which is an N-(äÄ4-(substituted thiazol-4-yl)phenylÜcarbamoylümethyl)amide derivative having a characteristic in that an aryl or heteroaryl group as an aromatic ring group is directly substituted on the N atom of amido group. Since said amide derivative has excellent anti-herpesvirus action, it is useful as medicaments and antiviral agents, particularly as preventive or therapeutic agents for various diseases accompanied by Herpesviridae virus infections, illustratively, varicella (chickenpox) accompanied by varicella zoster virus infection, shingles accompanied by the recurrent infection of latent varicella zoster virus, labial herpes and herpes encephalitis accompanied by HSV-1 infection, genital herpes accompanied by HSV-2 and the like various herpesvirus infections.
AU2002212734A 2000-11-10 2001-11-08 Amide derivatives Abandoned AU2002212734A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000-344354 2000-11-10
JP2000344354 2000-11-10
PCT/JP2001/009790 WO2002038554A1 (en) 2000-11-10 2001-11-08 Amide derivatives

Publications (1)

Publication Number Publication Date
AU2002212734A1 true AU2002212734A1 (en) 2002-05-21

Family

ID=18818562

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002212734A Abandoned AU2002212734A1 (en) 2000-11-10 2001-11-08 Amide derivatives

Country Status (11)

Country Link
US (1) US6949543B2 (en)
EP (1) EP1340750B8 (en)
JP (1) JP3913172B2 (en)
KR (1) KR20030045180A (en)
CN (1) CN1473157A (en)
AT (1) ATE302197T1 (en)
AU (1) AU2002212734A1 (en)
CA (1) CA2428184C (en)
DE (1) DE60112790T2 (en)
ES (1) ES2247177T3 (en)
WO (1) WO2002038554A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003095435A1 (en) * 2002-05-09 2003-11-20 Yamanouchi Pharmaceutical Co., Ltd. Amide derivatives
TW200505894A (en) 2003-08-08 2005-02-16 Yamanouchi Pharma Co Ltd Tetrahydro-2H-thiopyran-4-carboxamide derivative
JP5010917B2 (en) * 2003-08-29 2012-08-29 エグゼリクシス， インコーポレイテッド c-Kit Regulator and Method of Use
CA2553442A1 (en) * 2004-02-11 2005-08-25 Irm Llc Compounds and compositions as lxr modulators
CA2562714A1 (en) * 2004-05-13 2005-11-24 Boehringer Ingelheim International Gmbh Substituted thiophene-2-carboxylic acid amides, the production thereof and the use thereof as drugs
JPWO2006082821A1 (en) * 2005-02-02 2008-06-26 アステラス製薬株式会社 Preventive or therapeutic agent for diseases involving herpes virus
CA2596850A1 (en) * 2005-02-02 2006-08-10 Astellas Pharma Inc. Medicament for genital herpes
WO2006082822A1 (en) * 2005-02-02 2006-08-10 Astellas Pharma Inc. Agent for prevention/treatment of disease caused by acyclovir-resistant herpesvirus
JP4832093B2 (en) * 2005-02-02 2011-12-07 アステラス製薬株式会社 Method for producing tetrahydro-2H-thiopyran-4-carboxamide derivative
JP5011739B2 (en) * 2005-02-03 2012-08-29 アステラス製薬株式会社 Pharmaceutical composition containing tetrahydro-2H-thiopyran-4-carboxamide derivative
CA2661863A1 (en) * 2006-08-30 2008-03-06 F. Hoffmann-La Roche Ag Inhibitors for glyt-1
US9403789B2 (en) 2008-02-21 2016-08-02 Sequoia Pharmaceuticals, Inc. Benzofuran-containing amino acid inhibitors of cytochrome P450
EP2351565A1 (en) 2008-10-20 2011-08-03 Astellas Pharma Inc. Medicine for preventing or treating pain related to herpes zoster
US9212134B2 (en) 2010-09-13 2015-12-15 Microbiotix, Inc. Inhibitors of viral entry into mammalian cells
JP5641054B2 (en) * 2010-12-03 2014-12-17 富士通株式会社 Novel compound, kinesin spindle protein inhibitor and application thereof
CN103275034B (en) * 2013-04-16 2015-07-08 南京工业大学 Preparation method of micromolecule cathepsin D inhibitor
TW202038947A (en) 2018-11-28 2020-11-01 德商創新分子有限責任公司 Helicase primase inhibitors for treating cancer in a combination therapy with oncolytic viruses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997024343A1 (en) * 1995-12-29 1997-07-10 Boehringer Ingelheim Pharmaceuticals, Inc. Phenyl thiazole derivatives with anti herpes virus properties
AU3289299A (en) * 1998-02-19 1999-09-06 Tularik Inc. Antiviral agents
WO2000029399A1 (en) * 1998-11-12 2000-05-25 Boehringer Ingelheim (Canada) Ltd. Antiherpes compounds

Also Published As

Publication number Publication date
KR20030045180A (en) 2003-06-09
US6949543B2 (en) 2005-09-27
EP1340750A1 (en) 2003-09-03
CA2428184C (en) 2010-03-30
EP1340750A4 (en) 2004-01-21
ATE302197T1 (en) 2005-09-15
ES2247177T3 (en) 2006-03-01
CA2428184A1 (en) 2002-05-16
US20040034232A1 (en) 2004-02-19
WO2002038554A1 (en) 2002-05-16
DE60112790T2 (en) 2006-05-18
EP1340750B8 (en) 2005-10-19
DE60112790D1 (en) 2005-09-22
JPWO2002038554A1 (en) 2004-03-18
JP3913172B2 (en) 2007-05-09
CN1473157A (en) 2004-02-04
EP1340750B1 (en) 2005-08-17

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