TR200101664T2 - Heterocyclic carboxamide-containing thio re inhibitors of herpesviruses containing phenylenediamine group - Google Patents

Heterocyclic carboxamide-containing thio re inhibitors of herpesviruses containing phenylenediamine group

Info

Publication number
TR200101664T2
TR200101664T2 TR2001/01664T TR200101664T TR200101664T2 TR 200101664 T2 TR200101664 T2 TR 200101664T2 TR 2001/01664 T TR2001/01664 T TR 2001/01664T TR 200101664 T TR200101664 T TR 200101664T TR 200101664 T2 TR200101664 T2 TR 200101664T2
Authority
TR
Turkey
Prior art keywords
carbon atoms
inhibitors
herpesviruses
thio
heterocyclic carboxamide
Prior art date
Application number
TR2001/01664T
Other languages
Turkish (tr)
Inventor
David Bloom Jonathan
Joseph Curran Kevin
Joseph Digrandi Martin
George Dushin Rusell
Richard Jones Thomas
Albert Lang Stanley
Antonia Ross Adma
Anthony Terefenko Eugene
Mark O'hara Bryan
Original Assignee
American Home Products Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corporation filed Critical American Home Products Corporation
Publication of TR200101664T2 publication Critical patent/TR200101664T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • AIDS & HIV (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Formülü (I) olan ve , G'nin monosiklik heteroaril olduGu; X'in bir baG, -NH, 1 ila 6 karbon atomlu alkil, 1 ila 6 karbon atomlu alkenil, 1 ila 6 karbon atomlu alkoksi, 1 ila 6 karbon atomlu tioalkil, 1 ila 6 karbon atomlu alkilamino, veya (CH)J olduGu; J'nin 1 ila 6 karbon atomlu alkil, 3 ila 7 karbon atomlu sikloalkil fenil veya benzil; ve n'nin 1 ila 6 aras nda bir tam say olduGu ve insan sitomegalovirus, herpes simplex viruslar , Epstein-Barr virusu, varicella-zoster virusu,insan herpes viruslar -6 ve -7, ve Kaposi herpesvirusu dahil olmak üzere herpes viruslar ile ilgili hastal klar n tedavisinde yararl olan bir bileçik.Formula (I) and G is monocyclic heteroaryl; X is a baG, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino with 1 to 6 carbon atoms, or (CH) J. ; J is alkyl of 1 to 6 carbon atoms, cycloalkyl phenyl of 3 to 7 carbon atoms or benzyl; and n is an integer from 1 to 6 and related to herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpes viruses -6 and -7, and Kaposi herpesvirus. A useful bracelet in the treatment of diseases.

TR2001/01664T 1998-12-09 1999-12-06 Heterocyclic carboxamide-containing thio re inhibitors of herpesviruses containing phenylenediamine group TR200101664T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20855998A 1998-12-09 1998-12-09

Publications (1)

Publication Number Publication Date
TR200101664T2 true TR200101664T2 (en) 2002-03-21

Family

ID=22775044

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01664T TR200101664T2 (en) 1998-12-09 1999-12-06 Heterocyclic carboxamide-containing thio re inhibitors of herpesviruses containing phenylenediamine group

Country Status (18)

Country Link
EP (1) EP1144397A3 (en)
JP (1) JP2002531554A (en)
CN (1) CN1348446A (en)
AU (1) AU1934700A (en)
BG (1) BG105581A (en)
BR (1) BR9916046A (en)
CA (1) CA2350767A1 (en)
CZ (1) CZ20011956A3 (en)
EA (1) EA200100631A1 (en)
HU (1) HUP0200232A2 (en)
ID (1) ID30158A (en)
IL (1) IL143182A0 (en)
NO (1) NO20012832L (en)
PL (1) PL349217A1 (en)
SK (1) SK7682001A3 (en)
TR (1) TR200101664T2 (en)
WO (1) WO2000034258A2 (en)
ZA (1) ZA200104377B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6166028A (en) * 1998-12-09 2000-12-26 American Home Products Corporation Diaminopuridine-containing thiourea inhibitors of herpes viruses
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
EP1259485B1 (en) 2000-02-29 2005-11-30 Millennium Pharmaceuticals, Inc. BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa
US7220768B2 (en) * 2003-02-11 2007-05-22 Wyeth Holdings Corp. Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus
CN101595092B (en) 2006-11-02 2012-02-01 米伦纽姆医药公司 Methods of synthesizing pharmaceutical salts of a factor XA inhibitor
EP2914592B1 (en) * 2012-11-03 2017-10-11 Boehringer Ingelheim International GmbH Inhibitors of cytomegalovirus
EP2914591B1 (en) * 2012-11-03 2017-10-11 Boehringer Ingelheim International GmbH Inhibitors of cytomegalovirus
CN110565100B (en) * 2019-07-12 2021-05-07 西北工业大学 Cobaltocene cation-based corrosion inhibitor and preparation method and use method thereof
EP4382527A1 (en) 2021-08-05 2024-06-12 Zhejiang Hisun Pharmaceutical Co., Ltd. Aromatic acetylene derivative, and preparation method therefor and use thereof
WO2023088718A1 (en) 2021-11-19 2023-05-25 Basf Se Bicyclic compounds for the control of invertebrate pests
CN115433093A (en) * 2022-09-26 2022-12-06 无锡双启科技有限公司 Preparation method of 3-chloro-4-trifluoromethylaniline
CN115710190A (en) * 2022-11-16 2023-02-24 常州佳德医药科技有限公司 4-methoxy-2-amino-N, N-dimethylaniline, preparation method and application

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958983A (en) * 1997-04-10 1999-09-28 Pharmacia & Upjohn Company Polyaromatic antiviral compositions

Also Published As

Publication number Publication date
ID30158A (en) 2001-11-08
HUP0200232A2 (en) 2002-05-29
EP1144397A3 (en) 2002-09-11
EP1144397A2 (en) 2001-10-17
BR9916046A (en) 2001-10-02
CN1348446A (en) 2002-05-08
NO20012832L (en) 2001-08-07
AU1934700A (en) 2000-06-26
EA200100631A1 (en) 2002-02-28
IL143182A0 (en) 2002-04-21
WO2000034258A2 (en) 2000-06-15
NO20012832D0 (en) 2001-06-08
WO2000034258A3 (en) 2001-11-29
PL349217A1 (en) 2002-07-01
CZ20011956A3 (en) 2001-10-17
ZA200104377B (en) 2002-12-20
JP2002531554A (en) 2002-09-24
BG105581A (en) 2001-12-31
CA2350767A1 (en) 2000-06-15
SK7682001A3 (en) 2002-07-02

Similar Documents

Publication Publication Date Title
TR200101664T2 (en) Heterocyclic carboxamide-containing thio re inhibitors of herpesviruses containing phenylenediamine group
NZ507032A (en) 1,3,4-thiadiazoles useful for the treatment of herpes and cytomegalovirus infections
EP1046391A3 (en) Use of aminosubstituted hydroxybenzophenones as photostable UV-filters in cosmetic and pharmaceutical preparations
IL99755A0 (en) Hydroxymethyl(methylenecyclopentyl)purines and pyrimidines and pharmaceutical compositions containing the same
PT91575A (en) PROCEDE DE PREPARATION DE BENZYLAMINES USEFUL DISUBTITUTES COMME MEDICAMENTS
WO2000034261A3 (en) Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group
NO20012834L (en) Acetamide- and substituted acetamide-containing thiourea inhibitors for herpes virus
ZA937859B (en) Antiretroviral acyl compounds
CA2301967A1 (en) Azetidinone derivatives for the treatment of hcmv infections
PH31682A (en) 4-Iminoquinolines, process for their preparation, and their use.
EA200100635A1 (en) DERIVATIVES OF THIOMOCHEVIA AS HERPES VIRUS INHIBITORS
DE69731483D1 (en) BETA-L-DIOXOLANURIDINE ANALOGS FOR TREATING AND PREVENTING BY EBV, VZV OR HV-8 CAUSED VIRAL INFECTION
IL60443A (en) 2,2-dichlorocyclopropyl-methylphosphoric acid derivatives,their preparation and their use in combating pests
PT1021405E (en) AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS
EP1120415A4 (en) Substituted isoxazolylthiophene compounds
ES2062427T3 (en) NEW DERIVATIVES OF BENZONAFTIRIDINA-1,8 AND ITS PREPARATION.
DE59915244D1 (en) Cosmetic or pharmaceutical preparations containing 1,3,5-triazine derivatives and zinc oxide
KR950703976A (en) Compositions Containing Acyclovir-Like Compounds and 2'-Vinyl substituted Nucleoside Analogs for the Treatment of Viral Infections
TH14131A (en) Nucleosides which have therapeutic properties
ES2154191A1 (en) 2-alkyl-5-halo-3-[2'-(tetrazol-5-yl)-biphenyl-4-ylmethyl]-3h-imidazole-4-carboxaldehyde acetal derivatives, their preparation and use
TH14131EX (en) Nucleosides which have therapeutic properties